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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence and Deep Learning in Medical Imaging
edited by Eros Montin and Giuseppe Carluccio
submission deadline 20 Apr 2026 | 6 articles | Viewed by 5657 | Submission Open
Keywords: magnetic resonance imaging; radiomics; artificial intelligence (AI); deep learning; clinical and translational medicine; MRI safety; radiogenomics; multiomics
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advances in Anesthesia and Intensive Care During Perioperative Period
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 5556 | Submission Open
Keywords: general anesthesia; intensive care medicine; post intensive care syndrome; perioperative management; fast track; pain management; complications; postoperative outcome; digitalization; big data; AI; closed-loop systems; machine learning; clinical decision support; telemedicine
(This special issue belongs to the Section Intensive Care)
Cardiovascular Risks in Autoimmune and Inflammatory Diseases
edited by and
submission deadline 20 Apr 2026 | 5 articles | Viewed by 5456 | Submission Open
Keywords: autoimmune diseases; inflammation; cardiovascular risk; atherosclerosis; biological therapy; immunomodulatory therapy; lipid metabolism; cardiovascular risk factors; thrombosis; endothelial dysfunction
(This special issue belongs to the Section Immunology & Rheumatology)
Autoimmune Skin Diseases: Innovations, Challenges, and Opportunities
edited by Shany Sherman
submission deadline 20 Apr 2026 | 4 articles | Viewed by 4993 | Submission Open
Keywords: healthcare utilization; inflammatory skin diseases; photodermatoses; collagen vascular disease; immunobullous disorders; graft-versus-host disease
(This special issue belongs to the Section Dermatology)
Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort
edited by Cesare Gregoretti and Giuliano Lo Bianco
submission deadline 20 Apr 2026 | 8 articles | Viewed by 4479 | Submission Open
Keywords: pain management; pain medicine; anesthesia; analgesia; anesthesiology
(This special issue belongs to the Section Anesthesiology)
Immunotherapy of Hematological Malignancies: The State of the Art submission deadline 20 Apr 2026 | 1 articles | Viewed by 3905 | Submission Open
Keywords: antibody-drug conjugates; bispecific antibodies; chimeric antigen receptor-engineered natural killer cell; chimeric antigen receptor T-cells; cytokine release syndrome; immune checkpoint in-hibitors; immunosuppression; immunotherapy; monoclonal antibodies; neurotoxicities
(This special issue belongs to the Section Hematology)
Emerging Diagnostic and Treatment Approaches for Gynecological Cancers
edited by Marco D'Indinosante
submission deadline 20 Apr 2026 | 3 articles | Viewed by 3511 | Submission Open
Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiogenic Shock and Cardiac Arrest: Updates, Challenges and Opportunities
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 3441 | Submission Open
Keywords: cardiac arrest; extracorporeal membrane oxygenation; extracorporeal CPR; cardiopulmonary resuscitation; cardiogenic shock; resuscitation; prognostication
(This special issue belongs to the Section Cardiology)
Imaging in Diagnosis and Treatment of Musculoskeletal Disorders
edited by Francesco Porta and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3268 | Submission Open
Keywords: ultrasound; ultrasound-guided injections; imaging-guided procedures
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Spine Surgery: Current Practice and Future Directions
edited by Claudio Bernucci and Francesco Costa
submission deadline 20 Apr 2026 | 1 articles | Viewed by 3196 | Submission Open
Keywords: degenerative; spinal trauma; spine tumors; neurosurgery; spine surgery; spinal deformity; scoliosis; robotics surgery; spinal cord injury; clinical practices; regenerative therapies
(This special issue belongs to the Section Clinical Neurology)
Targeted Medicine in Postoperative Pain Management
edited by and Eleni Moka
submission deadline 20 Apr 2026 | 2 articles | Viewed by 3039 | Submission Open
Keywords: precision medicine; postoperative analgesia; pain control; drug delivery systems; surgical pain management; personalized interventions
(This special issue belongs to the Section Anesthesiology)
News in the Pathogenesis, Diagnosis and Treatment of Systemic Sclerosis
edited by Mayka Freire and Bernardo Sopeña
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2872 | Submission Open
Keywords: systemic sclerosis; scleroderma; capillaroscopy; autoantibodies; pathogenesis
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Management of Pediatric Heart Diseases
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 2680 | Submission Open
Keywords: pediatric heart diseases; children; pediatric cardiology; congenital heart disease; clinical management; congenital heart surgery; outcome
(This special issue belongs to the Section Clinical Pediatrics)
Prostatectomy: Clinical Updates and Perspectives
edited by Antonio Nacchia
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2317 | Submission Open
Keywords: single port; prostatectomy; robotics; RARP; prostate cancer
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances in Skin Cancer: A Closer Look at Non-Melanoma Types
edited by Andrea Paradisi
submission deadline 20 Apr 2026 | 3 articles | Viewed by 2266 | Submission Open
Keywords: basal cell carcinoma; squamous cell carcinoma; actinic keratosis; diagnosis; treatment; non-melanoma skin cancer (NMSC)
(This special issue belongs to the Section Dermatology)
Neuropathic Pain: From Prevention to Diagnosis and Management
edited by Enrico Martin
submission deadline 20 Apr 2026 | 1 articles | Viewed by 2128 | Submission Open
Keywords: neuropathic pain; clinical research; TMR; RPNI; preclinical studies; QoL; PROMS; translational medicine; pain mechanisms
(This special issue belongs to the Section Clinical Neurology)
Advances in the Management of Oral Lichen Planus: A Comprehensive Clinical Perspective
edited by Zuzanna Ślebioda and
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2080 | Submission Open
Keywords: oral lichen planus; treatment; topical treatment; systemic treatment; oral mucosa; oral pathology; immunosuppressive therapy
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Oral Cancer: Clinical Updates and Perspectives submission deadline 20 Apr 2026 | 1 articles | Viewed by 2060 | Submission Open
Keywords: oral cancer; oral surgery; dental implant; tooth extraction; oral health; early detection; biomarkers; targeted therapy; immunotherapy
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Chronic Disease Management and Rehabilitation in Older Adults
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 2002 | Submission Open
Keywords: chronic disease; older adults; geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; health promotion
(This special issue belongs to the Section Geriatric Medicine)
Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases
edited by and
submission deadline 20 Apr 2026 | 3 articles | Viewed by 1909 | Submission Open
Keywords: echocardiography; cardiac diseases; 3D echo; stress; myocardial strain; intracardiac; subclinical cardiac disease
(This special issue belongs to the Section Cardiology)
Clinical Management of Frailty
edited by , Walter Sepulveda-Loyola and
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1535 | Submission Open
Keywords: frailty; comprehensive geriatric assessment; assessment; monitoring; functional decline; physical performance; ex-ercise interventions; nutritional strategies; interventions; adverse outcomes
(This special issue belongs to the Section Geriatric Medicine)
Novel Insights into Clinical Diagnosis and Management of Degenerative Cervical Myelopathy
edited by , Francesco Costa and Filippo Maria Polli
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1483 | Submission Open
Keywords: degenerative cervical myelopathy (DCM); cervical spondylotic myelopathy (CSM); cervical spinal stenosis; cervical cord compression; MRI of the cervical spine; cervical spine surgery; physical therapy; rehabilitation; ossification of the posterior longitudinal ligament (OPLL); cervical deformity (e.g.; kyphosis and lordosis); patient-reported out-comes; surgical outcome prediction
(This special issue belongs to the Section Clinical Neurology)
Current Updates and Advances in Hemodialysis
edited by Edita Žiginskienė
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1420 | Submission Open
Keywords: kidney replacement therapy; hemodialysis; hemodiafiltration; vascular access; dialysis membranes; dialysis complications; dialysis adequacy; outcomes
(This special issue belongs to the Section Nephrology & Urology)
Implant Dentistry: New Challenges and Complication Management
edited by Jordi Gargallo
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1292 | Submission Open
Keywords: navigation surgery; accuracy; computer-aided surgery; computer-assisted; three-dimensional imaging; fixed implant prostheses; zirconia; CAD/CAM; patient satisfaction; peri-implantitis; quality of life; retreatment; tooth loss; connective tissue; keratinized tissue; soft tissue management; bone regeneration; bone grafting; immediate implant placement; immediate implant loading
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Novel Technologies to Assist Emergency Medical Care
edited by and Young Soon Cho
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1254 | Submission Open
Keywords: emergency medical services; artificial intelligence in emergency medicine; telemedicine and remote patient monitoring; wearable health technologies; point-of-care diagnostics; automated decision support systems; robotics in emergency medicine; pre-hospital care innovations
(This special issue belongs to the Section Emergency Medicine)
Respiratory Medicine in the Oldest-Old
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1188 | Submission Open
Keywords: oldest-old; respiratory system with aging; pneumonia; epidemiology; COPD; interstitial lung disease; bronchial asthma; lung cancer; mycobacterial or fungal infections; peri-/post-operative status; respiratory frailty; social problems and end of life
(This special issue belongs to the Section Respiratory Medicine)
Current Challenges and Innovations in Spine Deformity: Biomechanics, Imaging and AI-Driven Analysis
edited by Dong-Ho Kang
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1137 | Submission Open
Keywords: spinal deformity; cervical deformity; biomechanics; postural alignment; sagittal imbalance; medical imaging; radiographic analysis; artificial intelligence; machine learning; deep learning; phenotyping; computer-assisted diagnosis; predictive modeling; surgical planning
(This special issue belongs to the Section Orthopedics)
Preoperative Optimization in Cardiac Surgery
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1076 | Submission Open
Keywords: preoperative optimization; cardiac surgery; risk assessment; comorbid conditions; multidisciplinary collaboration; perioperative risks; cardiovascular evaluation
(This special issue belongs to the Section Cardiology)
Total Joint Arthroplasty: Clinical Advances and Innovations in Surgical Techniques and Rehabilitation
edited by , Marco Minelli and Federico Della Rocca
submission deadline 20 Apr 2026 | 1 articles | Viewed by 1062 | Submission Open
Keywords: total joint arthroplasty; hip replacement; knee arthroplasty; robotic-assisted surgery; minimally invasive techniques; implant design; postoperative rehabilitation; periprosthetic joint infection; surgical innovation
(This special issue belongs to the Section Orthopedics)
Clinical Care and Rehabilitation for Neuromuscular Diseases submission deadline 20 Apr 2026 | 1 articles | Viewed by 955 | Submission Open
Keywords: neuromuscular diseases; myopathy; neuropathy; motor neuron disease; amyotrophic lateral sclerosis; diseases of neuromuscular junction; neurorehabilitation; rehabilitation; clinical care; neuroscience
(This special issue belongs to the Section Clinical Rehabilitation)
Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition
edited by Michael D. Diamantidis
submission deadline 20 Apr 2026 | 1 articles | Viewed by 755 | Submission Open
Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)
(This special issue belongs to the Section Hematology)
Pediatric Dentistry: Real-World Clinical Insights submission deadline 20 Apr 2026 | 1 articles | Viewed by 720 | Submission Open
Keywords: pediatric dentistry; minimally invasive dentistry; new technologies; biomaterials; innovative management approaches; caries management; pulp management; dental trauma; molar incisor hypomineralization; public health services research; epidemiological research; translational research
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update
edited by Yacob G. Tedla
submission deadline 20 Apr 2026 | 1 articles | Viewed by 702 | Submission Open
Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification
(This special issue belongs to the Section Vascular Medicine)
Clinical Updates in Pediatric Radiology submission deadline 20 Apr 2026 | Viewed by 688 | Submission Open
Keywords: pediatric radiology; advances in pediatric imaging; pediatric neuroimaging; artificial in-telligence in pediatric imaging; radiomics and machine learning; low-field MRI techniques; magnetic resonance imaging in pediatrics; computed tomography in pediatrics; radiation dose optimization; patient-centred imaging protocols
(This special issue belongs to the Section Clinical Pediatrics)
Orofacial Pain: Innovations in Treatment Modalities and Patient Care
edited by Takahiko Nagamine
submission deadline 20 Apr 2026 | 1 articles | Viewed by 660 | Submission Open
Keywords: orofacial pain; treatment; patient care; oral dysfunction; chronic pain; burning mouth syndrome; temporomandibular joint pain: oral cenesthopathy; atypical odontalgia; phantom bite syndrome
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Maternal Fetal Medicine
edited by and Anna Franca Cavaliere
submission deadline 20 Apr 2026 | 1 articles | Viewed by 617 | Submission Open
Keywords: drugs use during pregnancy; fetal treatment; pregnancy complications; infectious diseases; neonatal poor adaptation syndrome
(This special issue belongs to the Section Obstetrics & Gynecology)
Intrarenal Surgery for Kidney Stones and Other Kidney Diseases
edited by Razvan Multescu
submission deadline 20 Apr 2026 | 1 articles | Viewed by 509 | Submission Open
Keywords: intrarenal surgery; flexible ureteroscopy; percutaneous nephrolithotomy (PCNL); Mini-PCNL; thulium laser; ureteral access sheaths; flexible and navigable suction (FANS); upper urinary tract urothelial tumors
(This special issue belongs to the Section Nephrology & Urology)
Clinical Update on Thoracic Trauma
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 502 | Submission Open
Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation
(This special issue belongs to the Section Respiratory Medicine)
Recent Advances in Endocrine Surgery—2nd Edition
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 497 | Submission Open
Keywords: endocrine surgery; thyroid; thyroid cancer; parathyroid; parathyroidectomy; adrenal glands; disorders of hepatobiliary and gastrointestinal tract
(This special issue belongs to the Section General Surgery)
Optimizing Outcomes in Emergency Medicine and Cardiopulmonary Resuscitation submission deadline 20 Apr 2026 | 1 articles | Viewed by 491 | Submission Open
Keywords: emergency medicine; cardiopulmonary resuscitation; prehospital care; outcome prediction; post-pesuscitation care; advanced life support; emergency response systems; medical ethics; simulation in medicine
(This special issue belongs to the Section Emergency Medicine)
Clinical Updates in Imaging of Musculoskeletal Diseases submission deadline 20 Apr 2026 | 1 articles | Viewed by 411 | Submission Open
Keywords: musculoskeletal imaging; ultrasound; magnetic resonance; sport imaging; rheumatology; nerve imaging
(This special issue belongs to the Section Nuclear Medicine & Radiology)
New Advances and Clinical Outcomes of Endocrinology
edited by Stefana Catalina Bilha and
submission deadline 20 Apr 2026 | Viewed by 260 | Submission Open
Keywords: endocrinology; obesity; metabolic and bone disease; chronic conditions
(This special issue belongs to the Section Endocrinology & Metabolism)
Prostate Surgery: The Latest Advances and Future Trends
edited by Akhil K. Das and
submission deadline 20 Apr 2026 | Viewed by 256 | Submission Open
Keywords: benign prostatic hyperplasia (BPH); minimally invasive surgical therapies (MIST); laser enucleation (HoLEP; ThuLEP); Aquablation; Rezum; robotic prostatectomy; anatomic enucleation
(This special issue belongs to the Section Nephrology & Urology)
Ischemic and Hemorrhagic Complications of Uncommon Cerebrovascular Diseases: Cutting-Edge Clinical Research, Reviews, and Expert Opinions
edited by Mariel G. Kozberg and Alexis T. Roy
submission deadline 20 Apr 2026 | Viewed by 249 | Submission Open
Keywords: cerebrovascular disease; ischemic stroke; hemorrhagic stroke; genetics; vasculopathy; headache; superficial siderosis; vascular malformations
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates and Perspectives on Transcranial Magnetic Stimulation (TMS)—2nd Edition submission deadline 20 Apr 2026 | Viewed by 218 | Submission Open
Keywords: non-invasive brain stimulation; transcranial magnetic stimulation; motor cortex; neuroplasticity; motor learning; dementia; stroke; movement disorders; depression; spinal cord; neuropsychiatric disorders
(This special issue belongs to the Section Clinical Neurology)
Interventional Ultrasound Associated with Rehabilitation in the Treatment of Muscolo-Skeletal Disease
edited by Stefano Galletti and
submission deadline 20 Apr 2026 | Viewed by 194 | Submission Open
Keywords: ultrasound; infiltrative treatment; musculoskeletal imaging; rehabilitation; orthopedic; rheumatology; interventional ultrasound
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Global Expert Views on Aortic Valve Repair and Replacement: 2nd Edition submission deadline 20 Apr 2026 | Viewed by 172 | Submission Open
Keywords: aortic valve pathologies; minimally invasive approach; aortic valve repair; aortic valve replacement; imaging techniques
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Oculoplastic Surgery: From Eyelid Reconstruction to Innovative Techniques
edited by Argyrios Tzamalis
submission deadline 20 Apr 2026 | Viewed by 168 | Submission Open
Keywords: oculoplastic surgery; eyelid reconstruction; orbital surgery; novel minimally invasive; image guided
Clinical Advances in Musculoskeletal Pain submission deadline 20 Apr 2026 | Viewed by 126 | Submission Open
Keywords: musculoskeletal pain; chronic pain; primary musculoskeletal pain; secondary chronic musculoskeletal pain; multi-disciplinary pain treatment; imaging in interventional pain management
(This special issue belongs to the Section Orthopedics)
Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes
edited by Athanassios A. Kyrgidis and
submission deadline 20 Apr 2026 | Viewed by 120 | Submission Open
Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life
(This special issue belongs to the Section Dermatology)
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