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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovations and Advances in Breast Cancer Research and Treatment

edited by

Palma Fedele

submission deadline 25 Mar 2026 | 5 articles | Viewed by 8775 | Submission Open

Keywords: breast cancer; early detection; genomics; personalized medicine; targeted therapies; survivorship; quality of life; artificial intelligence; machine learning; immunotherapy

(This special issue belongs to the Section Oncology)

Airway Management: From Basic Techniques to Innovative Technologies

edited by Kunal Karamchandani and Sheila Nainan Myatra

submission deadline 25 Mar 2026 | 5 articles | Viewed by 7962 | Submission Open

Keywords: airway management; physiologically difficult airway; videolaryngoscopy; esophageal intubation; artificial intelligence

(This special issue belongs to the Section Intensive Care)

Psoriasis and Psoriatic Arthritis: How to Treat in the Era of Biologics and Small Molecule Inhibitors: 3rd Edition

edited by

Mayumi Komine

and

Takemichi Fukasawa

submission deadline 25 Mar 2026 | 2 articles | Viewed by 6888 | Submission Open

Keywords: psoriasis; psoriatic arthritis; biologics; small molecule inhibitors; conventional therapies

(This special issue belongs to the Section Dermatology)

Innovations in Head and Neck Surgery

edited by

Achille Tarsitano

and Giovanni Badiali

submission deadline 25 Mar 2026 | 3 articles | Viewed by 6765 | Submission Open

Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation

(This special issue belongs to the Section Otolaryngology)

Biomarkers and Diagnostics in Neurological Diseases

edited by Maria Ioanna Stefanou

submission deadline 25 Mar 2026 | 5 articles | Viewed by 6559 | Submission Open

Keywords: biomarkers; neurological diseases; diagnosis; lipoprotein(a); neurofilament protein; tau peptide; neuroimaging

(This special issue belongs to the Section Clinical Neurology)

Cardiac Surgery: Clinical Advances

edited by Carmelo Dominici, Giovanni Casali and

Antonio Nenna

submission deadline 25 Mar 2026 | 5 articles | Viewed by 5890 | Submission Open

Keywords: cardiac surgery; surgical innovation; minimally invasive techniques; robotic surgery; personalized medicine; advanced surgical technologies

(This special issue belongs to the Section Cardiology)

Clinical Advances in Valvular Heart Diseases

edited by

Mohammad Kassar

submission deadline 25 Mar 2026 | 3 articles | Viewed by 5769 | Submission Open

Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis

(This special issue belongs to the Section Cardiology)

Aortic Aneurysms: Recent Advances in Diagnosis and Treatment

edited by Marco Virgilio Usai, Giuseppe Asciutto and Michele Piazza

submission deadline 25 Mar 2026 | 5 articles | Viewed by 5361 | Submission Open

Keywords: aortic aneurysms; abdominal aortic; thoraco-abdominal aortic aneurysms (TAAAs); complex aortic anatomies; endovascular abdominal aortic aneurysm repair (EVAR); endovascular thoracic aortic aneurysm repair (TEVAR); endovascular treatment

(This special issue belongs to the Section Cardiovascular Medicine)

The Current State of Robotic Surgery in Urology

edited by

Luca Di Gianfrancesco

submission deadline 25 Mar 2026 | 5 articles | Viewed by 5326 | Submission Open

Keywords: robotic surgery; urology; surgical technique; multi-port; single port; major urological surgery; reconstructive surgery; robot-assisted radical cystectomy; patients’ selection

(This special issue belongs to the Section Nephrology & Urology)

Obstructive Sleep Apnea: Latest Advances and Prospects

edited by

Carlos O’Connor Reina

submission deadline 25 Mar 2026 | 4 articles | Viewed by 5268 | Submission Open

Keywords: obstructive sleep apnea; sleep medicine; myofunctional therapy; sleep surgery; neurostimulation; personalized treatment; biomarkers; adherence; home sleep testing

(This special issue belongs to the Section Otolaryngology)

Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis

edited by Alberto Gajofatto

submission deadline 25 Mar 2026 | 2 articles | Viewed by 4188 | Submission Open

Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Clinical Neurology)

Attention-Deficit–Hyperactivity Disorder (ADHD): Bridging Theory and Clinical Application

edited by Rafał R. Jaeschke

submission deadline 25 Mar 2026 | 2 articles | Viewed by 3948 | Submission Open

Keywords: ADHD; emotional dysregulation; diagnosis and assessment; pharmacological and non-pharmacological treatments; neurobiology; comorbidities

(This special issue belongs to the Section Mental Health)

Imaging and Surgery in Endometriosis—Recent Advances

edited by

Harald Krentel

and

Rudy Leon De Wilde

submission deadline 25 Mar 2026 | 2 articles | Viewed by 3366 | Submission Open

Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems

(This special issue belongs to the Section Obstetrics & Gynecology)

Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives

edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi

submission deadline 25 Mar 2026 | 2 articles | Viewed by 3074 | Submission Open

Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Acute Care for Traumatic Injuries and Surgical Outcomes: 2nd Edition

edited by Matthias Fröhlich and Michael Caspers

submission deadline 25 Mar 2026 | 3 articles | Viewed by 2901 | Submission Open

Keywords: trauma injuries; orthopedics; polytrauma; emergency care; coagulation disorders; fractures; surgical outcomes; acute care; diagnostic imaging

(This special issue belongs to the Section Emergency Medicine)

Diagnostic and Therapeutic Challenges in Infective Endocarditis

edited by Lorenzo Bertolino

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2594 | Submission Open

Keywords: infective endocarditis; complications; diagnostic challenges; therapeutic approach; epidemiology; clinical correlates

(This special issue belongs to the Section Cardiology)

Hemophilia: Current Trends and Future Directions

edited by

Jonathan C. Roberts

and

Michael B. Nichol

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2116 | Submission Open

Keywords: hemophilia; prophylaxis; gene therapy; burden of illness; quality of life; patient reported outcomes; hemarthrosis; women and hemophilia

(This special issue belongs to the Section Hematology)

Breast Cancer: Advances in Clinical and Personalized Practices

edited by Massimo Lodi and Sébastien Molière

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2060 | Submission Open

Keywords: breast cancer; radiology; surgical oncology; breast reconstruction; personalized medicine; quality of life; multidisci-plinary approach; new technologies

(This special issue belongs to the Section Oncology)

Intracranial Aneurysms: Diagnostics and Current Treatment

edited by Vincenzo Antonelli and

Roberto Colasanti

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2049 | Submission Open

Keywords: neurovascular diseases; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms; subarachnoid hemorrhage; neurorehabiltation

(This special issue belongs to the Section Clinical Neurology)

Recent Advances in Prenatal Diagnosis and Maternal Fetal Medicine

edited by

Anca Angela Simionescu

and

Ştefania Tudorache

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1949 | Submission Open

Keywords: prenatal; obstetrics; fetal abnormalities; intrauterine treatments; genetic disorders; pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Innovations in Laboratory Medicine to Advance Diagnostic and Improve Patient Outcomes

edited by

Jing Cao

and

Xin Yi

submission deadline 25 Mar 2026 | 2 articles | Viewed by 1712 | Submission Open

Keywords: health equity; laboratory diagnostics; near-patient testing; diagnostic access; underserved patient populations; disparities in healthcare; patient outcome

(This special issue belongs to the Section Clinical Laboratory Medicine)

Advances in Treatment and Prognosis for Acute Type A and Type B Aortic Dissections

edited by

Katsuhiko Oda

submission deadline 25 Mar 2026 | 2 articles | Viewed by 1477 | Submission Open

Keywords: acute aortic dissection; stent graft; false lumen expansion; thoracic endovascular aortic repair; initial surgery for Type A acute aortic dissection; frozen elephant trunk

(This special issue belongs to the Section Cardiovascular Medicine)

Multidisciplinary Approach to the Diagnosis and Treatment of Temporomandibular Disorders: Patient Care Challenges—2nd Edition

edited by

Monika Lukomska-Szymanska

and

Klara Saczuk

submission deadline 25 Mar 2026 | 2 articles | Viewed by 1449 | Submission Open

Keywords: multidisciplinary approach; mental health; bruxism; masticatory muscles; temporomandibular joint; orofacial pain; temporomandibular disorders

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances and Challenges in Laparoscopic Surgery

edited by Leonid Barkhatov

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1125 | Submission Open

Keywords: laparoscopic surgery; minimally invasive surgery; surgical outcomes; oncologic surgery; general surgery; learning curve

(This special issue belongs to the Section General Surgery)

From Hyperfunction to Insufficiency: A Comprehensive Look at Adrenal Disorders

edited by

Jorge Gabriel Ruiz-Sánchez

and Patricia Y. Fechner

submission deadline 25 Mar 2026 | 1 articles | Viewed by 890 | Submission Open

Keywords: primary aldosteronism; hypoaldosteronism; hypercortisolism; adrenal insufficiency; autonomous cortisol secretion; cushing syndrome

(This special issue belongs to the Section Endocrinology & Metabolism)

Corneal Surgery: From Innovation to Clinical Practice

edited by Joanna Wasielica-Poslednik

submission deadline 25 Mar 2026 | 1 articles | Viewed by 547 | Submission Open

Keywords: keratoplasty; penetrating keratoplasty; DMEK; eye banking; corneal surgery

(This special issue belongs to the Section Ophthalmology)

Translational Immunology in Clinical Medicine: From Preclinical Insights to Therapeutic Impact

edited by

Soheil Tavakolpour

submission deadline 25 Mar 2026 | 1 articles | Viewed by 544 | Submission Open

Keywords: translational immunology; autoimmune disease; autoinflammatory disease; immune-mediated diseases; oncology; preclinical models; immune efficacy and safety; mechanism of action; immunotoxicity assessment

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Insights and Advances in Structural Heart Disease

edited by

David Roberts

submission deadline 25 Mar 2026 | 1 articles | Viewed by 430 | Submission Open

Keywords: TAVR; Mitra-Clip; Tri-Clip; Pascal; TricValve; PFO closure; LAAO closure; cardiac CT; cardiac MRI; transoesopha-geal echocardiography

(This special issue belongs to the Section Cardiology)

Latest Advances in Ocular Surface Diseases

edited by Barbara Burgos-Blasco

submission deadline 25 Mar 2026 | Viewed by 255 | Submission Open

Keywords: cornea; keratitis; ocular surface disease; dry eye; corneal ulcer; keratoplasty; conjunctival disease

(This special issue belongs to the Section Ophthalmology)

Myeloid-Derived Suppressor and Innate Immune Cells in Hematologic, Malignant and Chronic Diseases

edited by

Helen A. Papadaki

submission deadline 25 Mar 2026 | Viewed by 192 | Submission Open

Keywords: myeloid-derived suppressor cells (MDSCs); macrophages; monocytes; eosinophils; neutrophils; malignancy; cancer; autoimmunity; infection; chronic inflammation; therapeutic target; biomarker; precision medicine; molecular pathways; bone marrow microenvironment

(This special issue belongs to the Section Hematology)

Gastrointestinal Perforations: Diagnosis and Management to Reduce Morbidity and Mortality

edited by

Rossella Reddavid

submission deadline 25 Mar 2026 | Viewed by 184 | Submission Open

Keywords: gastrointestinal perforation; diagnosis; surgery; acute peritonitis; sepsis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

State of the Art in Clinical Management of Sedation and Anesthesia Challenges

edited by Basavana Goudra

submission deadline 25 Mar 2026 | Viewed by 156 | Submission Open

Keywords: anesthesia; oxygenation; sedative agents; ventilation; airway management

(This special issue belongs to the Section Anesthesiology)

"Visceral Aneurysm" in 2025: Recent Advances and Treatment (Second Edition)

edited by Enrico Maria Marone

submission deadline 25 Mar 2026 | Viewed by 140 | Submission Open

Keywords: visceral aneurysms; vascular surgery; endovascular treatment; lparoscopic surgery; robotic surgery; embolization; flow-diverting stents; covered stents

(This special issue belongs to the Section Vascular Medicine)

Breast MRI: An Update

edited by

Filippo Pesapane

and

Anna Rotili

submission deadline 25 Mar 2026 | Viewed by 123 | Submission Open

Keywords: breast cancer; breast imaging; magnetic resonance imaging; diffusion-weighted imaging; contrast-enhanced sequences; artificial intelligence

(This special issue belongs to the Section Obstetrics & Gynecology)

Meibomian Gland Dysfunction and Dry Eye Diseases

edited by

Reiko Arita

and

KyoungYul Seo

submission deadline 25 Mar 2026 | Viewed by 111 | Submission Open

Keywords: meibomian gland; meibomian gland dysfunction; dry eye disease; ocular surface; meibography; lipid layer; tear film; inflammation; therapy; diagnosis; epidemiology; clinical study

(This special issue belongs to the Section Ophthalmology)

Endocarditis: Clinical Updates on Diagnosis, Treatment and Management

edited by Katarzyna Holcman

submission deadline 25 Mar 2026 | Viewed by 96 | Submission Open

Keywords: infective endocarditis; PET; SPECT; echocardiography; antimicrobial therapy; cardiac surgery; multimodality imaging

(This special issue belongs to the Section Cardiology)

Osteosarcoma: New Insights into Diagnosis and Treatment

edited by Lars M. Wagner

submission deadline 25 Mar 2026 | Viewed by 94 | Submission Open

Keywords: osteosarcoma; tyrosine kinase inhibitors; immunotherapy; clinical trial design; intratumoral heterogeneity; liquid biopsy; metastasectomy; deep learning; translational research; targeted therapy

(This special issue belongs to the Section Oncology)

Advances in Schizophrenia and Related Psychotic Disorders

edited by Giovanni Camardese and Michele Ribolsi

submission deadline 25 Mar 2026 | Viewed by 92 | Submission Open

Keywords: psychosis; schizophrenia; severe mental illness; psychopharmacology; negative symptoms; antipsychotics

(This special issue belongs to the Section Mental Health)

Artificial Intelligence in Acute Care Surgery and Trauma Health Care

edited by

Sergio M. Navarro

and Daniel Stephens

submission deadline 25 Mar 2026 | Viewed by 88 | Submission Open

Keywords: artificial neural networks; robotic surgery; virtual reality; augmented reality; artificial intelligence; virtual reality; deep learning

(This special issue belongs to the Section Emergency Medicine)

Contemporary Trends in Cardiovascular Prevention

edited by Alessandro Durante and

Alessandro Mazzapicchi

submission deadline 25 Mar 2026 | Viewed by 85 | Submission Open

Keywords: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia

(This special issue belongs to the Section Cardiovascular Medicine)

Diagnosis and Treatment for Hearing Loss: Expert Views

edited by

Robert A. Saadi

and John L. Dornhoffer

submission deadline 25 Mar 2026 | Viewed by 82 | Submission Open

Keywords: hearing loss; cochlear implants; hearing aid technology; regenerative medicine; diagnostic audiology

(This special issue belongs to the Section Otolaryngology)

Clinical Management of Vestibular Disorders

edited by

Eun-ju Jeon

and Sun-Young Oh

submission deadline 25 Mar 2026 | Viewed by 79 | Submission Open

Keywords: vestibular disorders; vertigo; dizziness; balance; BPPV; vestibular rehabilitation; telemedicine; multidisciplinary care

(This special issue belongs to the Section Otolaryngology)

Pulmonary Embolism: Bridging Cutting-Edge Research and Clinical Practice

edited by

Bedros Taslakian

and Vivian Lee Bishay

submission deadline 25 Mar 2026 | Viewed by 77 | Submission Open

Keywords: pulmonary embolism; catheter-directed thrombectomy; catheter-directed thrombolysis; post-pulmonary embolism syndrome; chronic thromboembolic disease; chronic thromboembolic pulmonary hypertension

(This special issue belongs to the Section Respiratory Medicine)

From Heart to Brain: Interdisciplinary Perspectives on Cerebral Infarction

edited by

Laurent Suissa

and Jean-Claude Deharo

submission deadline 25 Mar 2026 | Viewed by 74 | Submission Open

Keywords: ischemic stroke; cardioembolic stroke; atrial fibrillation; heart– brain axis; neurocardiology; post-stroke cardiac dysfunction; stroke prevention; cerebral infarction; cardiac monitoring in stroke; secondary stroke prevention

(This special issue belongs to the Section Clinical Neurology)

Hematologic Malignancies: Treatment Strategies and Future Challenges: 2nd Edition

edited by Masaaki Noguchi

submission deadline 25 Mar 2026 | Viewed by 61 | Submission Open

Keywords: hematologic malignancies; relapse; refractory; drug resistance; therapeutic strategies; new target; biomarkers; new insights

(This special issue belongs to the Section Hematology)

Dentistry and Oral Surgery: Current Status and Future Prospects

edited by

Dragana Gabrić

Ivona Bago

and

Marko Vuletić

submission deadline 26 Mar 2026 | 3 articles | Viewed by 6649 | Submission Open

Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Ocular Surface, Retina, and Choroid as Mirrors of Systemic and Genetic Diseases

edited by

Giacomo Visioli

Alisi Ludovico

and

Alessandro Lambiase

submission deadline 27 Mar 2026 | 4 articles | Viewed by 9622 | Submission Open

Keywords: ocular surface; retina; choroid; systemic diseases; genetic conditions; biomarkers; diagnostic imaging; neuroretina; infectious diseases

(This special issue belongs to the Section Ophthalmology)

Current Progress in the Treatment of Cornea and Ocular Surface Diseases

edited by Marco Messina and

Giuseppe Giannaccare

submission deadline 27 Mar 2026 | 2 articles | Viewed by 2982 | Submission Open

Keywords: dry eye disease; meibomian gland dysfunction; microbial keratitis; auto-immune keratitis; peripheral ulcerative keratitis; neurotrophic keratopathy; corneal dystrophies; corneal degenerations; mucous membrane pemphigoid; ocular cicatricial disease; Stevens– Johnson syndrome; pterygium; ocular graft-versus-host disease; limbal stem cell deficiency; keratoplasty; amniotic membrane transplantation; keratoconus; corneal collagen cross-linking; antimicrobial therapy; corneal neurotization; vernal keratoconjunctivitis; atopic keratoconjunctivitis

(This special issue belongs to the Section Ophthalmology)

Vascular and Endovascular Surgery: Current Progress and Future Challenges

edited by Michael Keese and Martin Sigl

submission deadline 28 Mar 2026 | 5 articles | Viewed by 7182 | Submission Open

Keywords: vascular; endovascular; surgery; therapy; aneurysm; vascular; PAD; venous; interdisciplinary

(This special issue belongs to the Section Vascular Medicine)

Clinical Management and Treatment of Orthopedic Oncology: 2nd Edition

edited by

Muhammad Umar Jawad

and Danielle Elizabeth Greig

submission deadline 28 Mar 2026 | 5 articles | Viewed by 3869 | Submission Open

Keywords: bone metastasis; primary bone tumors; soft tissue sarcoma; limb salvage; multimodal treatment strategies

(This special issue belongs to the Section Orthopedics)

Displaying special issue 951-1000 on page 20 of 31.

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