Genetic Susceptibility in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 2
Special Issue Editor
Special Issue Information
Dear Colleagues,
Rapid advancements in genomic technologies and bioinformatics have transformed our understanding of genetic susceptibility in human diseases. Genetic variants, combined with environmental factors, critically influence disease onset, progression, and therapeutic outcomes across diverse populations. This Special Issue of International Journal of Molecular Sciences aims to compile cutting-edge research on the genetic mechanisms underlying disease susceptibility, emphasizing their potential to advance precision medicine and public health strategies. We seek original research, comprehensive reviews, and insightful perspectives that deepen our knowledge and drive innovation in this field.
Topics of interest include the following:
- The identification of genetic variants linked to disease susceptibility;
- Gene–environment interactions shaping disease risk;
- Epigenetic mechanisms influencing predisposition;
- Biomarkers for disease screening, diagnosis, and prognosis;
- Pharmacogenomics and personalized therapeutic approaches;
- Polygenic risk scores for clinical risk assessment;
- Genetic factors in complex diseases (e.g., cancer, cardiovascular, neurodegenerative, autoimmune);
- Population genetics and diversity in susceptibility;
- Bioinformatics tools and databases for genetic research;
- Ethical, legal, and social implications of genetic studies.
This open access Special Issue welcomes contributions that bridge fundamental science, clinical applications, and translational research, fostering the development of novel diagnostics and targeted therapies.
Dr. Xiaowu Gai
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bioinformatics
- genomics
- genetic susceptibility to disease
- genetic variation
- gene–environment interactions
- biomarkers
- epigenetic mechanisms
- pharmacogenomics
- population genetics
- bioinformatics tools and databases
- novel diagnostics
- targeted therapies
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
