Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 22
Special Issue Editors
Interests: cardiologist; heart failure; right ventricular uncoupling; biomarkers; personalized therapy; cardiac resynchronization
Interests: heart failure; acute coronary syndrome; pulmonary hypertension; coronary microvascular dysfuntion; coronary artery disease
Special Issues, Collections and Topics in MDPI journals
Interests: gender; cardiovascular prevention; Mediterranean diet; lifestyle
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Traditional cardiovascular risk factors are the initial triggers of increased atherosclerotic burden with direct effects on cardiac and renal function deterioration. Chronic kidney disease (CKD) and heart failure (HF) are two conditions that often occur silently in the initial stages but can manifest itself only in the more advanced stages of the disease. Additionally, when they occur simultaneously, the risk of adverse events is further increased. The available epidemiological data only highlights a liaison between risk factors that predispose to the onset and deterioration of both renal diseases and heart failure. However, to date there are no large-scale studies that have explored and compared heart failure, renal failure and cardio-renal failure. The inconsistence in recognizing a specific cardio-renal disease phenotype has led to an ineffective prevention and treatment strategy with a growing need to develop a precise definition of cardio-renal metabolic syndrome, its progression and management models focused on harmonizing specific guidelines and current scientific evidence.
Cardiovascular-renal-metabolic syndrome (CKM) is defined as a cluster of pathologies attributable to interactions between cardiovascular risk factors such as obesity, dia-betes, hypertension, dyslipidemia, hyperuricemia, capable of promoting both chronic kidney disease (CKD) and cardiovascular diseases (CVD), including heart failure, atrial fibrillation, cor-onary artery disease, stroke and systemic atherosclerosis. This association has a profound impact on CV and renal morbidity and mortality with a significant socioeconomic impact on the quality of life and on the risk of patients affected by the aforementioned conditions. The high prevalence of cardio-renal and metabolic alterations in the population represent a public health emergency, but it can also be an opportunity to undertake a preventive treatment aimed at reducing the burden and a therapeutic target for patients affected by heart and kidney failure. In this sense, there are currently several therapeutic options that improve the metabolic risk profile, renal function and have cardioprotective effects.
In this context, it seems appropriate to establish a model care capable of providing indications on the definition, staging, risk profiles, diagnostic algorithms and therapeutic approaches of this emerging disease. The conceptualization and organization of a network involving cardiologists and multidisciplinary skills which broad their knowledge in the field of diabetes, nephrology and metabolic diseases, aim at establishing a common strategy and possibly customize CKM management.
We invite you to contribute either original research or review article focusing order to improve cardiovascular–renal–metabolic health, it appears necessary to investigate the following aspects factors: (1) to clarify the definition of cardiovascular-renal-metabolic syndrome; (2) to establish a cardiovascular–renal–metabolic staging strategies that promote prevention throughout the life course; (3) to promote prevention algorithms that include and define the CV risk clusters most closely related to cardio-renal events; (4) to identify strategies for the treatment and management of cardiovascular and renal diseases caused by pre-existing metabolic pathologies. In this context, it seems appropriate to establish a model care capable of providing indications on the definition, staging, risk profiles, diagnostic algorithms and therapeutic approaches of this emerging disease. The conceptualization and organization of a network involving cardiologists and multidisciplinary skills which broad their knowledge in the field of diabetes, nephrology and metabolic diseases, aim at establishing a common strategy and possibly customize CKM management.
Dr. Alberto Palazzuoli
Prof. Dr. Francesco Fedele
Prof. Dr. Anna Mattioli
Guest Editors
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Keywords
- cardiovascular risk factors
- metabolic syndrome
- chronic kidney disease
- heart failure
- endothelial dysfunction
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