Advances in Targeted Therapies and Immunometabolic Pathways in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 8
Special Issue Editor
2. Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
3. South Florida VA Foundation for Research and Education, Miami, FL 33125, USA
4. Department of Surgery, Division of Thoracic Surgery, University of Miami, Miami, FL 33136, USA
Interests: platinum-resistant lung cancer; cisplatin; carboplatin resistant
Special Issue Information
Dear Colleagues,
The intricate interplay between tumor metabolism and immune evasion has established a transformative frontier in cancer therapy. As traditional approaches are challenged by drug resistance and limited durability, emerging strategies integrating targeted therapies with immunomodulation offer new hope. This Special Issue highlights the converging evidence that metabolic reprogramming, characterized by altered metabolism, not only sustains malignant growth but also reshapes the tumor immune microenvironment. Recent studies demonstrate that therapies targeting oncogenic signaling pathways, such as MYC, KRAS, and PI3K, can enhance tumor antigenicity and T-cell infiltration when combined with immune checkpoint blockade. Moreover, efforts to convert “cold” tumors into “hot” ones through modulation of the tumor microenvironment or the activation of innate immune pathways have shown promise in augmenting immunotherapeutic efficacy. Cellular therapies, including CAR-T and engineered NK cells, are being redesigned to overcome metabolic suppression within solid tumors. Collectively, these advances underscore the necessity of integrative, metabolism-informed approaches to immunotherapy.
This Special Issue brings together novel mechanistic insights, preclinical models, and translational strategies that will inform the next generation of combination treatments aimed at overcoming resistance and improving patient outcomes across diverse malignancies.
Dr. Medhi Wangpaichitr
Guest Editor
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Keywords
- immunotherapy
- targeted therapy
- tumor metabolism pathway
- tumor microenvironment
- immune checkpoint blockade
- immune evasion
- glucose/amino acids/lipid metabolism
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