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The Chitosan Biomaterials: Advances and Challenges, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 609

Special Issue Editors


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Guest Editor
Physical and Colloidal Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
Interests: quality by design (QbD); analytical quality by design (AQbD); drug systems formulation (Chitosan); Surfaces characteristics (wettability/hydrophilicity/hydrophobicity—pharmaceutical powders)
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: biomaterials (collagen drug delivery systems); rheology; cosmeceuticals; drug systems formulation and technological processes optimization; response surface methodology; Taguchi design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chitosan is a versatile biopolymer, with applications in drug delivery systems, vaccine formulations, wound healing, tissue regeneration, cosmetics, dentistry, food packing, agriculture, etc. The basic properties of chitosan, which make it an optimal material for use, are as follows: biocompatibility, biodegradability, mucoadhesion, and enhanced permeability. It also has its own actions, such as antibacterial, antifungal, hemostatic, and antioxidant actions, which make it advantageous for use in various fields. Recent research has shown that chitosan also has immunostimulatory, anti-tumor, and anti-inflammatory actions.

Aside from its numerous actions and effects, chitosan has amino and hydroxyl functional groups in its structure, which lead to chitosan derivatives with improved physico-chemical properties and effects being obtained, as well as to the establishment of interactions with a variety of molecules used to develop biomaterials.

Through this Special Issue, titled “The Chitosan Biomaterials: Advances and Challenges, 3rd Edition”, we will gather original research and review articles on the development, preparation, actions and evaluation of various biomaterials based on chitosan and its derivatives, as well as their applications.

Prof. Dr. Lacramioara Popa
Prof. Dr. Mihaela Violeta Ghica
Prof. Dr. Cristina Elena Dinu-Pirvu
Guest Editors

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Keywords

  • chitosan
  • chitosan biomaterials
  • chitosan derivatives
  • drug delivery
  • wound healing
  • tissue regeneration
  • dentistry
  • smart biomaterials

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Published Papers (1 paper)

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Research

20 pages, 4124 KB  
Article
Modification of Chitosan with (−)-Gossypol and (−)-Gossypol Acetic Acid Using Free-Radical Grafting Method
by Anna Hlukhaniuk, Małgorzata Świętek, Anna Kołodziej, Aleksandra Wesełucha-Birczyńska, Andrii Mahun, Libor Kobera and Daniel Horák
Int. J. Mol. Sci. 2025, 26(23), 11721; https://doi.org/10.3390/ijms262311721 - 3 Dec 2025
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Abstract
One of the approaches to increase bioavailability and stability of hydrophobic biologically active compounds is their incorporation into polymer backbone. This work deals with the modification of chitosan (CS) with gossypol (GS), a phenolic compound with confirmed anticancer properties, by the free-radical grafting [...] Read more.
One of the approaches to increase bioavailability and stability of hydrophobic biologically active compounds is their incorporation into polymer backbone. This work deals with the modification of chitosan (CS) with gossypol (GS), a phenolic compound with confirmed anticancer properties, by the free-radical grafting method. The series of the CS derivatives with increasing content of GS were prepared using pure GS or gossypol acetate (GSA) and compared to the control CS (cCS). The starting CS, cCS, and GS-containing derivatives were characterized using Fourier-transform infrared (FTIR), Raman, and 13C ssNMR spectroscopies; elemental and thermogravimetric analysis to evaluate the influence of the radicals and GS on the properties of polymers was performed. The Folin–Ciocalteu (F-C) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods were used to evaluate antioxidant properties of GS-modified CSs. Additionally, the polymer solubility and the specific viscosity of the solutions were determined. The content of GS in polymers raised proportionally with increasing amount of GS added to the reaction mixture, thereby enhancing the ability to scavenge free radicals. The type of GS used (GS or GSA) in polymers affected the degree of CS crosslinking (higher for pure GS), polymer solubility (lower for pure GS), the amount of grafted GS (~20% higher for GSA), and antioxidant properties in favor of GSA. Full article
(This article belongs to the Special Issue The Chitosan Biomaterials: Advances and Challenges, 3rd Edition)
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