Developmental Origins of Kidney Disease: Renal Programming
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 537
Special Issue Editor
Interests: air pollution; chronic kidney disease; congenital anomalies of kidney and urinary tract; renal development; renal programming; renin angiotensin system
Special Issue Information
Dear Colleagues,
Adverse environmental exposures during early life—including the fetal and perinatal periods—can profoundly disrupt normal developmental trajectories, thereby increasing the susceptibility to chronic diseases in adulthood, such as chronic kidney disease. Numerous studies have investigated the consequences of suboptimal intrauterine environments, including maternal dietary imbalances, maternal diabetes, exposure to glucocorticoids or environmental toxicants, including fine particles, and placental insufficiency. These investigations have consistently demonstrated impairments in renal morphogenesis, reduced nephron endowment, and the dysregulation of key genes as well as signaling pathways that govern kidney development, postnatal growth, and the progression of renal disease in offspring.
This Special Issue aims to feature high-quality original research articles and comprehensive reviews that advance our understanding of the molecular mechanisms underlying renal programming as well as novel therapeutic approaches to renal reprogramming. We particularly welcome studies offering mechanistic insights at the molecular and cellular levels.
Dr. Hyung-Eun Yim
Guest Editor
Manuscript Submission Information
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Keywords
- air pollution
- chronic kidney disease
- congenital anomalies of the kidneys and urinary tract
- high-risk pregnancy
- nephrogenesis
- renal programming
- renin angiotensin system
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