Molecular Research in Acute Lung Injury

Dear Colleagues,

As we know, Acute Lung Injury (ALI) is a disorder of acute inflammation that causes the disruption of the lung endothelial and epithelial barriers. It is characterized by the loss of alveolar–capillary membrane integrity, excessive transepithelial neutrophil migration, and the release of pro-inflammatory mediators. The acute phase of ALI and its more severe form—acute respiratory distress syndrome (ARDS)—are characterized by the influx of protein-rich edema fluid into the alveolar spaces as a consequence of the increased permeability of the alveolar–capillary barrier. All these factors can lead to respiratory failure.

The ethiology of Acute Lung Injury (ALI) is diverse, from pneumonia and aspiration to sepsis and trauma. In particular, a form of ALI called primary graft dysfunction occurs frequently after lung transplantation. Importantly, the treatement options for ALI are scarce and mainly supportive.

This Special Issue is focused on the molecular mechanisms involved in the development and resolution of ALI. Despite the body of work published relating to this subject, the precise mechanisms regulating ALI development and resolution remain unclear. Morover, more research involving pharmacological interventions is paramount. This Special Issue aims to consolidate current knowledge on ALI, highlighting molecular mechanisms and clinical relevance through original research and review articles.

Dr. Emilia Lecuona
Guest Editor

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