Metabolic Crossroads in Cardiac Pathophysiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 June 2026) | Viewed by 1102
Editor
Special Issue Information
Dear Colleagues,
Cardiovascular disease remains the leading global cause of morbidity and mortality, yet its underlying pathophysiology is increasingly recognized as a convergence of metabolic, inflammatory, and hemodynamic dysfunction. This Special Issue, "Metabolic Crossroads in Cardiac Pathophysiology", invites original research articles, reviews, and translational perspectives that explore how metabolic perturbations drive cardiac remodeling, heart failure, ischemia–reperfusion injury, arrhythmogenesis, and vascular dysfunction.
We are particularly interested in submissions that examine the interface between cardiac energetics and systemic metabolic disorders—such as diabetes, obesity, insulin resistance, dyslipidemia, and chronic kidney disease—as well as investigations into mitochondrial function, substrate utilization, oxidative stress, nutrient signaling pathways, and the role of emerging cardiometabolic therapies (e.g., SGLT2 inhibitors, GLP-1 receptor agonists, and novel peptide-based interventions).
This Special Issue aims to highlight the evolving paradigm in which cardiac disease is viewed not solely as a mechanical or electrical failure, but as a metabolic syndrome of the heart. We welcome interdisciplinary work spanning basic science, omics-based discovery, clinical trials, imaging, and bioengineering, especially where novel mechanisms or therapeutic targets are identified.
We encourage authors from across cardiovascular science, endocrinology, nephrology, and metabolism to contribute their work and help shape this timely and transformative discourse.
Topics of interest include, but are not limited to, the following:
- Cardiac metabolism in heart failure with preserved or reduced ejection fraction (HFpEF/HFrEF);
- Myocardial insulin resistance and lipid overload;
- Metabolomic and proteomic profiling in cardiometabolic disease;
- Endothelial and glycocalyx dysfunction in metabolic states;
- Mitochondrial energetics and redox imbalance in ischemic heart disease;
- Novel pharmacologic and non-pharmacologic metabolic interventions;
- Gut microbiota, TMAO, and metabolic inflammation in CVD;
- Chronobiology and metabolic regulation of cardiac function.
Join us in advancing the understanding of how metabolic networks intersect with cardiac pathophysiology and in identifying new avenues for therapeutic innovation.
Prof. Dr. Robert J. Chilton
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- cardiometabolic disease
- cardiac metabolism
- heart failure
- mitochondrial dysfunction
- insulin resistance
- cardiometabolic therapies
- metabolomics
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