Natural Antioxidants—Sources, Characteristics, and Biological Activity

Dear Colleagues,

Oxidative stress plays a central role in the progression of numerous pathological conditions. It arises from an imbalance between the production of reactive species—such as reactive oxygen species, reactive nitrogen species, and reactive sulfur species—and the body’s capacity to neutralize them. These reactive species can damage key biomolecules, including lipids, proteins, and DNA, leading to cellular dysfunction and triggering inflammatory responses. Natural antioxidants, sourced from plants, microbes, and marine organisms, have garnered significant interest due to their ability to counteract oxidative damage. They are capable of exhibiting synergistic effects when combined or used in specific formulations, enhancing their bioavailability and efficacy. Understanding their structure–activity relationships and mechanisms of action will be crucial for guiding future drug development and nutraceutical innovation. However, the full potential of nature’s antioxidant repertoire remains largely unexplored, despite extensive global research efforts. A multitude of novel compounds are yet to be isolated and characterized, offering promising avenues for improving human health and advancing therapeutic strategies.

Dr. Maciej Spiegel
Guest Editor

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