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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Symbiosis and Molecular Mechanisms in Water Treatment

edited by

Binghan Xie

submission deadline 20 Aug 2026 | Viewed by 157 | Submission Open

Keywords: microbiomics; water treatment; bioenergy recovery; emerging contaminant degradation; antibiotic resistance genes (ARGs); microalgae biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Roles of Phytochemicals in Molecular Signaling Networks

edited by

Jui-Hung Yen

submission deadline 20 Aug 2026 | Viewed by 155 | Submission Open

Keywords: phytochemicals; molecular signaling pathways; inflammation; apoptosis; chronic diseases; cancer; cardiovascular diseases; structure– activity relationships

(This special issue belongs to the Section Bioactives and Nutraceuticals)

RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications

edited by Karl M Thompson

submission deadline 20 Aug 2026 | Viewed by 153 | Submission Open

Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics

(This special issue belongs to the Section Molecular Biology)

The Latest Molecular Insights into Animal Nutrition

edited by

Bin Feng

submission deadline 20 Aug 2026 | Viewed by 151 | Submission Open

Keywords: reproduction; animal production; development; immunity; emissions; digestion efficiency; microbiome; metabolism; molecular signaling; nutritional strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Medicinal Value of Plant Extracts

edited by

Myrna Déciga-Campos

and

Rosa Ventura-Martínez

submission deadline 20 Aug 2026 | Viewed by 147 | Submission Open

Keywords: medicinal plant; essential oil; cancer; diabetes; pain; inflammation; neurodegenerative diseases; metabolites; bioactive compounds; toxicity; safety; mutagenicity; genotoxicity; biological evaluations; efficacy; molecular

(This special issue belongs to the Section Molecular Pharmacology)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 20 Aug 2026 | Viewed by 146 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment

edited by Ruba Al Abdulla

submission deadline 20 Aug 2026 | Viewed by 146 | Submission Open

Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity

(This special issue belongs to the Section Molecular Oncology)

Intracellular Host-Bacteria Dynamics: Unraveling the Molecular Basis

edited by

Apichai Tuanyok

submission deadline 20 Aug 2026 | Viewed by 144 | Submission Open

Keywords: intracellular bacteria; granuloma; immune invasion; Mycobacterium tuberculosis; Burkholderia pseudomallei; Francisella; Brucella; Listeria; Coxiella

(This special issue belongs to the Section Molecular Microbiology)

Mechanisms of Action of Environmental Neurotoxicants During Critical Periods of Brain Development

edited by

Yael Abreu-Villaça

submission deadline 20 Aug 2026 | Viewed by 140 | Submission Open

Keywords: environmental neurotoxicants; developmental neurotoxicity; critical windows; animal models; early exposure; long-term programming

(This special issue belongs to the Section Molecular Neurobiology)

Predictive, Prognostic Biomarkers and Therapeutic Targets of Breast Cancer: Second Edition

edited by Antonella Ciabattoni and Fabiana Gregucci

submission deadline 20 Aug 2026 | Viewed by 134 | Submission Open

Keywords: radiotherapy; breast cancer; stereotactic body radiotherapy; brain radiosurgery; target therapy; immunotherapy; tailored systemic therapy

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Pituitary Endocrinology

edited by

Antonio M. Picó

and Cristina Lamas

submission deadline 20 Aug 2026 | Viewed by 134 | Submission Open

Keywords: pituitary tumors; hypopituitarism; growth and puberty disorders; acromegaly; Cushing’ s disease and silent corticotroph tumors; silent pituitary tumors; hypophysitis; molecular endocrinology and transcription factors; hormone resistance; precision endocrinology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 20 Aug 2026 | Viewed by 128 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure– activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Vitamin D in Reproductive Disorders: Determinants, Metabolism, and Downstream Biological Mechanisms

edited by

Eugenia Mata-Greenwood

submission deadline 20 Aug 2026 | Viewed by 114 | Submission Open

Keywords: vitamin D; perinatal corticosteroids; placental insufficiency; intrauterine growth restriction; cortisol metabolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neural Signaling: The Perspective of Molecular Genetics

edited by

Chunlai Wu

submission deadline 20 Aug 2026 | Viewed by 105 | Submission Open

Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 20 Aug 2026 | Viewed by 97 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

Cancer Stem Cells as Key Immunotherapy Targets

edited by Cosmin Andrei Cismaru

submission deadline 20 Aug 2026 | Viewed by 90 | Submission Open

Keywords: cancer stem cells; immunotherapy; immune escape; tumor antigens; cancer recurrence

(This special issue belongs to the Section Molecular Immunology)

Effects of Radiation in Health and Disease

edited by

Raffaella Lazzarini

submission deadline 20 Aug 2026 | Viewed by 78 | Submission Open

Keywords: extremely low-frequency magnetic fields; proteins and gene interaction; ionizing and non-ionizing radiations

(This special issue belongs to the Section Molecular Biology)

New Research on Toxicology Research Models

edited by

Cláudia Maria Rosa Ribeiro

and

María Carolina Rocha-Pereira

submission deadline 20 Aug 2026 | Viewed by 57 | Submission Open

Keywords: contaminants of emerging concern; aquatic organisms; in vitro; in vivo; mammalian approaches; mechanisms of toxicity; environmental risk assessment; one health

(This special issue belongs to the Section Molecular Toxicology)

Unknown Pathogenesis of Musculoskeletal Diseases and Basic Sciences: The Role of New Technologies

edited by

Gianluigi Pasta

submission deadline 20 Aug 2026 | Viewed by 1 | Submission Open

Keywords: AI; musculoskeletal diseases; pathogenesis; basic sciences; molecular mechanisms; genetics; immunology; biomechanics; translational research; experimental models; tissue engineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies for CNS Diseases Targeting Biogenic Amines and Their Receptors

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 20 Aug 2026 | Submission Open

Keywords: neurotransmitters; biogenic amines; receptors; ligands (antagonists; agonists; inverse agonists; biased ligands); neurodegenerative diseases (e.g.; Alzheimer's disease; Parkinson's disease); neuroinflammation; CNS cancers; autoimmune disease (e.g.; multiple sclerosis); neurological diseases; mental illness (schizophrenia; depression); epilepsy; pain; in vitro studies; in silico studies (ADMET; molecular modelling); in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

miRNA in Physiology and Pathophysiology

edited by

Ivan Jovanović

submission deadline 21 Aug 2026 | Viewed by 13 | Submission Open

Keywords: microRNAs; gene regulation; physiology; pathophysiology; biomarkers; complex diseases; cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by Vitor Engracia Valenti

submission deadline 25 Aug 2026 | Viewed by 96 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research on Lipidomics

edited by

Agata Kot-Wasik

submission deadline 25 Aug 2026 | Viewed by 59 | Submission Open

Keywords: lipids ; hyphenated chromatography– mass spectrometry ; biological samples ; sample preparation

(This special issue belongs to the Section Molecular Biology)

Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities

edited by

Giuseppe Di Giovanni

submission deadline 30 Aug 2026 | Viewed by 151 | Submission Open

Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities

edited by

Anthony Lemarié

submission deadline 30 Aug 2026 | Viewed by 98 | Submission Open

Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape

(This special issue belongs to the Section Molecular Neurobiology)

MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours

edited by

Kurt Sartorius

submission deadline 30 Aug 2026 | Viewed by 88 | Submission Open

Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Antiparasitic Agents

edited by Olga S. Koutsoni and

Maria Agallou

submission deadline 30 Aug 2026 | Viewed by 78 | Submission Open

Keywords: parasite genomics; parasite proteomics; metabolic pathways; parasite– host interactions; drug targets; mechanisms of drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Evolutionary Genetics of Pathogens

edited by Leonardo Gabriel Panunzi

submission deadline 30 Aug 2026 | Viewed by 73 | Submission Open

Keywords: pathogenicity; genome evolution; horizontal gene transfer; virulence factors; comparative genomics; pangenome analysis mobile genetic elements; computational biology; machine learning; host– pathogen interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cardioprotective Mechanisms in Myocardial Ischemia

edited by Virginia Pérez and Verónica D’annunzio

submission deadline 30 Aug 2026 | Viewed by 58 | Submission Open

Keywords: myocardial ischemia; ischemia– reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition

edited by Lukasz Szafron

submission deadline 30 Aug 2026 | Viewed by 54 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Targeting Oxidative Stress: New Insights into Disease Pathogenesis, Emerging Preventive Strategies and Novel Therapeutic Approaches

edited by Fabio Vivarelli and

Donatella Canistro

submission deadline 30 Aug 2026 | Viewed by 24 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; natural oxidative stress modulators; novel preventive/therapeutic strategies; ageing; cardiovascular diseases; regenerative medicine; neurodegeneration; environmental exposure; cancer

(This special issue belongs to the Section Molecular Biology)

Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease

edited by Sophia Lavrentiadou

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3457 | Submission Open

Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System

edited by

Hirotaka Sakamoto

submission deadline 31 Aug 2026 | 1 articles | Viewed by 927 | Submission Open

Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus

(This special issue belongs to the Section Molecular Neurobiology)

Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery

edited by

Betty Revon Liu

submission deadline 31 Aug 2026 | Viewed by 206 | Submission Open

Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations

edited by

José Luna-Muñoz

and Alejandra Morlett-Paredes

submission deadline 31 Aug 2026 | Viewed by 135 | Submission Open

Keywords: tauopathies and protein aggregation; amyloid beta and neurotoxicity; emerging proteins in neurodegeneration; molecular and morphological biomarkers; innovative therapies and experimental targets; artificial intelligence and neuropathological analysis

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy

edited by

Dominique Delmas

submission deadline 31 Aug 2026 | Viewed by 96 | Submission Open

Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes

(This special issue belongs to the Section Biochemistry)

Animal Models for Neurobiological Diseases

edited by

Hiroki Toyoda

and

Jana Tchekalarova

submission deadline 31 Aug 2026 | Viewed by 80 | Submission Open

Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics

edited by

Amal Kaddoumi

submission deadline 31 Aug 2026 | Viewed by 66 | Submission Open

Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood– brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms in Cardiovascular and Metabolic Diseases: Effective and Potential Treatments

edited by

Alex Cleber Improta-Caria

submission deadline 31 Aug 2026 | Viewed by 61 | Submission Open

Keywords: molecular mechanisms; cardiovascular diseases; metabolic diseases; microRNAs; circRNAs; long non-coding RNAs; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Nanostructured Materials for Energy, Environmental, and Biomedical Applications

edited by

Balaji Murugan

submission deadline 31 Aug 2026 | Viewed by 44 | Submission Open

Keywords: advanced sustainable materials; molecular engineering; energy conversion and storage (supercapacitor; solar cells; and batteries); electrocatalysis and photocatalysis; environmental remediation; biomedical applications; bio/electrochemical sensing and bioelectronics; molecular surface structure and interface chemistry; in situ/operando spectroscopy

(This special issue belongs to the Section Molecular Nanoscience)

Functional Precision Medicine in Rare Cancers: Organoid Models and Integrated Omics Profiling

edited by Gavin Robert Oliver and Carlton C Barnett

submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open

Keywords: organoids; rare cancer; new approach methodologies; oncology; precision medicine; functional precision medicine; multiomics; genomics; transcriptomics; epigenomics

(This special issue belongs to the Section Molecular Oncology)

Nanobiomaterials for Medical Research: From Molecular Mechanisms to Clinical Translation

edited by

Carmen Curutiu

Alina Maria Holban

and

Florin Iordache

submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open

Keywords: nanomaterials; biopolymers; medical research; chronic diseases; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Hydrogen Medicine: From Molecular Insights to Disease Intervention

edited by

Fei Xie

submission deadline 31 Aug 2026 | Viewed by 29 | Submission Open

Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia– reperfusion injury; clinical trials; signal transduction; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Placental Function and Pregnancy Complications

edited by Jezid Miranda

submission deadline 31 Aug 2026 | Viewed by 26 | Submission Open

Keywords: placental biology; pregnancy complications; preeclampsia; fetal growth restriction; angiogenic markers; maternal– fetal immunity; fetal growth; trophoblast; implementation; precision obstetrics; maternal mortality

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Aug 2026 | Viewed by 17 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Forward in Vasculitis: Genetics and Beyond, 2nd Edition

edited by

Marija Jelusic

submission deadline 31 Aug 2026 | Viewed by 13 | Submission Open

Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bacteriophages in the One Health Perspective: From Infection Therapy to Precision Medicine Through Diagnostics

edited by

Alicja Wegrzyn

submission deadline 31 Aug 2026 | Viewed by 1 | Submission Open

Keywords: bacteriophages; one health concept; bacteriophage therapy

(This special issue belongs to the Section Molecular Microbiology)

Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers, 4rd Edition

edited by

Andrzej Kutner

Geoffrey Brown

and Enikö Kallay

submission deadline 31 Aug 2026 | Submission Open

Keywords: drug design and discovery antimicrobial drugs; antiviral drugs; antibiotics; cancer prevention and treatment molecular modeling; molecular mechanisms; crystallography preclinical studies; pharmacokinetics; pharmacodynamics; pharmacognosy drug-protein interactions nuclear receptors; receptor agonists and antagonists; stem cells; activity profiling; vaccines; markers; and diagnostics drug carriers; dosage form; anti-crystal engineering; nanoparticles; dissolution testing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Advances in Coagulation and Bleeding

edited by