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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Diagnosis and Treatment of Gynaecological Cancers
edited by
submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open
Keywords: gynecological oncology; molecular biomarkers; precision medicine; tumor microenvironment; targeted therapy; early detection; immunotherapy; genomic profiling; drug resistance; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
New Discoveries in Virus–Cytoskeleton Regulation submission deadline 31 Dec 2025 | Viewed by 27 | Submission Open
Keywords: viruses; cytoskeleton dynamics; actin; tubulin and intermediate filaments; infection; pathogenesis; therapies
(This special issue belongs to the Section Molecular Biology)
Microbial Metagenomics: From Basic Science to Biotechnological Applications
edited by Rafael Antonio Rojas-Herrera
submission deadline 31 Dec 2025 | Viewed by 26 | Submission Open
Keywords: metagenomic; microbial ecology; bioremediation; ecological resilience; extremozyme bioprospecting; biodiversity
(This special issue belongs to the Section Molecular Microbiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Oncology
edited by
submission deadline 31 Dec 2025 | Viewed by 26 | Submission Open
Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy
(This special issue belongs to the Section Molecular Oncology)
25th Anniversary of IJMS: Updates and Advances in Macromolecules submission deadline 31 Dec 2025 | Viewed by 26 | Submission Open
Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship
(This special issue belongs to the Section Macromolecules)
Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease, 2nd Edition
edited by Dariusz Szukiewicz
submission deadline 31 Dec 2025 | Viewed by 26 | Submission Open
Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Associated with Exercise for Health and Performance
edited by Ciro José Brito
submission deadline 31 Dec 2025 | Viewed by 25 | Submission Open
Keywords: exercise science; sports medicine; aging; genetic and exercise; endocrinology; immunology
(This special issue belongs to the Section Molecular Biology)
Genetic Variants Involved in Breast and Ovarian Cancers submission deadline 31 Dec 2025 | Viewed by 25 | Submission Open
Keywords: breast and ovarian cancers; genetics; genomics; biomarkers; mutations; genetic variants; translational markers
(This special issue belongs to the Section Molecular Oncology)
Molecular Applications of Microbial and Marine-Derived Natural Products with Health Benefits
edited by Simona Negreş
submission deadline 31 Dec 2025 | Viewed by 24 | Submission Open
Keywords: microbial products; marine-derived products; pharmacological activity; key molecules; molecular mechanisms; drug discovery; nutraceuticals; therapy; prophylaxis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
25th Anniversary of IJMS: Updates and Advances in Molecular Informatics submission deadline 31 Dec 2025 | Viewed by 24 | Submission Open
Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering
(This special issue belongs to the Section Molecular Informatics)
Recent Advances in Genome-Edited Animal Models
edited by Takayuki Sakurai and
submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open
Keywords: genome editing; prime editing; base editing; CRISPRa/CRISPRi; knock-in/out; conditional genome editing; multiplex genome editing; manipulation of early embryos and germ cells; in vivo gene delivery; genome-edited animals; disease animal model
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Electrochemical Mechanisms of Metal Corrosion
edited by
submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open
Keywords: metal corrosion; molecular mechanisms; electrochemistry; surface chemistry; corrosion inhibitors; passivation
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Immunological Control of Vascular Plasticity: Insights into Arteriogenesis, Angiogenesis, and Atherosclerosis submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open
Keywords: vascular plasticity; arteriogenesis; angiogenesis; atherosclerosis; immune modulation; inflammation and vascular remodeling; translational vascular immunology; smooth muscle cell-/endothelial cell proliferation; sterile inflammation; collateral artery growth
(This special issue belongs to the Section Molecular Immunology)
Molecular Adaptations of Arthropod Vectors to Oxidative Stress submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open
Keywords: oxidative stress; arthropod vectors; molecular adaptation; redox biology; proteomics; stress response mechanisms
(This special issue belongs to the Section Molecular Biology)
Molecular Perspective of Alzheimer’s Disease
edited by
submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open
Keywords: Alzheimer’ s disease; amyloid peptide (toxic conformation); mutations (gamma-secretase); GWAS; risk factors; new treatment (monoclonal antibodies)
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into Antimicrobial Peptides with Anticancer Activity
edited by
submission deadline 31 Dec 2025 | Viewed by 21 | Submission Open
Keywords: antimicrobial peptides; cytotoxicity; selective anticancer drugs; omics approaches; anticancer peptide action
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications
edited by
submission deadline 31 Dec 2025 | Viewed by 20 | Submission Open
Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 20 | Submission Open
Keywords: melanoma; pathology; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Design of Polymer Composites for Biomedical Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open
Keywords: biocompatibility; polymers; biomaterials; tissue regeneration; mesenchymal cells; wound healing
(This special issue belongs to the Section Materials Science)
Endometrial Cancer: From Molecular Insights to Treatment
edited by Giuseppe Angelico
submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open
Keywords: endometrial cancer; molecular classification; TCGA; precision oncology; immunotherapy; targeted therapy; biomarkers; tumor microenvironment; genomics; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein-Targeted Therapeutics: Functional Modulation in Disease Pathways submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open
Keywords: protein-targeted therapeutics; proteins inhibitors; ligand binding; conformational changes
(This special issue belongs to the Section Biochemistry)
25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism
edited by
submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open
Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience
edited by Qi Zhang, and
submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open
Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes
(This special issue belongs to the Section Molecular Nanoscience)
Microtubule Cytoskeleton, Motor Proteins, and Other Cytoskeleton-Associated Proteins
edited by
submission deadline 31 Dec 2025 | Viewed by 18 | Submission Open
Keywords: microtubule cytoskeleton; motor proteins (kinesins and dyneins); cytoskeleton-associated proteins; cytoskeletal “ cross-talk” ; intracellular transport; cellular signaling and regulation; cellular processes (mitosis; migration; and polarity)
(This special issue belongs to the Section Biochemistry)
Synthesis and Structural Studies of Potential Anticancer Drugs
edited by Janusz Madaj
submission deadline 31 Dec 2025 | Viewed by 18 | Submission Open
Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Focus on Plant Biotechnology and Molecular Breeding submission deadline 31 Dec 2025 | Viewed by 18 | Submission Open
Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Targeted Peptide Drugs for Metabolic Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 17 | Submission Open
Keywords: metabolic disorders; peptide drugs; MASLD; receptor targeting; lipid regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Neuropharmacology in Neurodegenerative Disorders
edited by
submission deadline 31 Dec 2025 | Viewed by 17 | Submission Open
Keywords: neuropharmacology; neurodegenerative disorders; cognitive dysfunction; motor dysfunction; drug discovery; neuroprotection; neurogenesis; brain plasticity; biomarkers; AI (artificial intelligence)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment
edited by
submission deadline 31 Dec 2025 | Viewed by 17 | Submission Open
Keywords: mesenchymal stem/stromal cells (MSCs); MSC homing; MSC properties; immune cells; macrophages; injury; inflammation; cell therapy
(This special issue belongs to the Section Molecular Immunology)
Advances in Drug Synthesis Reactions: From Bench to Breakthroughs
edited by
submission deadline 31 Dec 2025 | Viewed by 17 | Submission Open
Keywords: organic synthesis; sustainability; scale-up synthesis; bio-orthogonal reactions; flow chemistry; green chemistry; natural product scaffolds; electrochemical synthesis; chemoenzymatic synthesis; automated and high-throughput synthesis
(This special issue belongs to the Section Molecular Pharmacology)
Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 16 | Submission Open
Keywords: injectable pharmacological agents; musculoskeletal disorders; injection therapies; platelet-rich plasma (PRP); hyaluronic acid
(This special issue belongs to the Section Molecular Pharmacology)
Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions
edited by
submission deadline 31 Dec 2025 | Viewed by 16 | Submission Open
Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways
(This special issue belongs to the Section Molecular Immunology)
Latest Review Papers in “Materials Science” Section
edited by
submission deadline 31 Dec 2025 | Viewed by 16 | Submission Open
Keywords: biomaterials; coatings; materials phenomena; machine learning; nanocomposites; artificial intelligence
(This special issue belongs to the Section Materials Science)
Computational Approaches in Drug Discovery and Design: From Molecular Modeling to Translational Applications submission deadline 31 Dec 2025 | Viewed by 16 | Submission Open
Keywords: computational drug discovery; molecular modeling; AI-driven drug design; molecular dynamics simulations; quantum chemistry; structure-based drug design; machine learning in pharmacology; virtual screening and docking; ADMET prediction; personalized medicine modeling
(This special issue belongs to the Section Molecular Informatics)
Molecular Research on the Pathology and Treatment of Sepsis and Non-Infectious Inflammatory Conditions
edited by
submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open
Keywords: sepsis; comorbidities; inflammation; molecular mechanisms; cytokine signaling; oxidative stress; leukocyte recruitment; therapeutic targets
(This special issue belongs to the Section Molecular Immunology)
Molecular Crosstalk in Stress-Induced Psychopathology
edited by Ilaria Demori and
submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open
Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota– gut– brain axis; Blood– brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open
Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways
(This special issue belongs to the Section Molecular Toxicology)
Molecular Insights into Skin Allergies: Cross-Disciplinary Approaches to Diagnosis and Therapy
edited by , Belén De la Hoz and
submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open
Keywords: skin allergy; dermatology; allergy management; allergic reaction; topical immune response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Biological Activities of Curcumin and Its Analogues
edited by Francis Johnson
submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open
Keywords: curcumin; analogues; natural compounds; inflammation; tissue reconstruction
(This special issue belongs to the Section Bioactives and Nutraceuticals)
RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications
edited by Karl M Thompson
submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open
Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics
(This special issue belongs to the Section Molecular Biology)
Micro/Nano-Structure Regulation of Two-Dimensional Materials
edited by
submission deadline 31 Dec 2025 | Viewed by 14 | Submission Open
Keywords: 2D materials; micro/nano-engineering; structure– property relationships
(This special issue belongs to the Section Materials Science)
Molecular Research on Prostate Cancer, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 13 | Submission Open
Keywords: prostate cancer; molecular biology; genomics; biomarkers; signaling pathways; precision medicine; treatment resistance; epigenetics; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Brain Tumor Pathogenesis
edited by Mugurel Petrinel Radoi
submission deadline 31 Dec 2025 | Viewed by 13 | Submission Open
Keywords: brain tumors; molecular pathogenesis; glioma biomarkers; tumor microenvironment; neuro-oncology; targeted therapy; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Current Research on Phenolic Profiles and Anti-Inflammatory Activities of Plants
edited by Chi-Rei Wu and Li-Wei Lin
submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open
Keywords: plants; phenolic profiles; inflammation; cardiovascular disorders; cancer; diabetes; neurodegenerative disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Pathogenesis of Central Nervous System Disorders, Interplay and Multifaceted Role of Glial Cells and Neuroprotective Mechanisms
edited by Matilde Balbi
submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open
Keywords: neurodegenerative disease; CNS disorders; glial cells; glia-cross talk; extracellular vesicles; calcium pathway; neuroinflammation; autophagy; excitotoxicity; glial phenotype
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Endocrine–Immune Crosstalk in Human Reproductive Health and Pathology
edited by Juan Pablo Mackern-Oberti
submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open
Keywords: T cells; B cells; autoimmune disease; reproduction; immunemodulation; inflammation; endocrinology; lactation
(This special issue belongs to the Section Molecular Immunology)
Next Generation Sequencing in Human Diseases
edited by
submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open
Keywords: NGS; single-cell analysis; metagenomics; forensic DNA analysis; precision medicine; genetic diagnostics; transplant monitoring; cell-free DNA; new allele and variant discovery
(This special issue belongs to the Section Molecular Informatics)
Novel Biochemical, Genetic, and Molecular Biology Approaches in Human Reproduction
edited by Athanasios Zikopoulos
submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open
Keywords: reproductive biology; infertilit; epigenetics in reproduction; maternal-fetal health; precision medicine
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section
edited by
submission deadline 31 Dec 2025 | Viewed by 10 | Submission Open
Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials
(This special issue belongs to the Section Materials Science)
Advances in Stem Cell Biology and Translational Medicine
edited by Yangluowa Qu
submission deadline 31 Dec 2025 | Viewed by 10 | Submission Open
Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research
(This special issue belongs to the Section Molecular Biology)
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