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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 4797 | Submission Open
Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies for IBD; ulcerative colitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Signaling and Stress Adaptation in Plants
edited by and
submission deadline 20 Nov 2025 | 7 articles | Viewed by 4521 | Submission Open
Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Splice-Switching Antisense Oligonucleotides: 30 Years after Advocating Exon-Skipping Therapy for Duchenne Muscular Dystrophy
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4450 | Submission Open
Keywords: antisense oligonucleotides; modified nucleic acid; splicing; splicing switch; exon skipping; pseudoexon; N-of-1; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Prebiotics, Probiotics and Postbiotics: 2nd Edition
edited by and Haruki Kitazawa
submission deadline 20 Nov 2025 | 4 articles | Viewed by 4440 | Submission Open
Keywords: probiotics; prebiotics; postbiotics; symbiotics; immunobiotics; functional foods; health improvement; mucosal immunology; microbiota
(This special issue belongs to the Section Molecular Microbiology)
Bacteriophage—Molecular Studies 6.0
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4430 | Submission Open
Keywords: bacteriophage biodiversity; regulation of bacteriophage development; molecular processes in bacteriophages; bacteriophage-based biotechnology; phage therapy
(This special issue belongs to the Section Biochemistry)
Astrocyte-Endothelial Interactions at the Blood-Brain Barrier, 2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4148 | Submission Open
Keywords: blood– brain barrier (BBB); astrocyte– endothelial interactions; cytokine signaling; astrocytic modulation; brain microvascular endothelial cells; chemokine receptors; BBB permeability; BBB dysfunction; BBB pharmacokinetics; cerebrovascular disease; oxidative stress; BBB models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Micro- and Nanomaterials for Biomedical Applications
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3941 | Submission Open
Keywords: biomaterials; medical applications; natural and synthetic polymers; tissue engineering; hydrogels; bone cement; drug delivery systems; dendrimers; micro- and nanocomposites; nanotechnology; bioceramics; biopharmaceutics; biosensing
(This special issue belongs to the Section Molecular Nanoscience)
FTIR Miscrospectroscopy: Opportunities and Challenges
edited by Simona Sabbatini
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3857 | Submission Open
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Physiology and Molecular Medicine of Molecular Hydrogen
edited by and John Nagi Kheir
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3810 | Submission Open
Keywords: molecular hydrogen; reactive oxygen species; nitric oxide; inflammation; cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3754 | Submission Open
Keywords: molecular detection; analytical techniques; nanosensors; food science; DNA analysis
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass submission deadline 20 Nov 2025 | 2 articles | Viewed by 3504 | Submission Open
Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization
(This special issue belongs to the Section Biochemistry)
Oral Cancer: Update on Molecular Pathology, Mechanisms and Treatments
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3487 | Submission Open
Keywords: oral cancer; mechanisms of incidence and development of oral cancer; metastasis; diagnosis; biomarkers; treatments (active ingredients; medicines; biomedicines; and gene therapy)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products and Synthetic Derivatives in Cancer and Inflammatory Diseases
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3486 | Submission Open
Keywords: angiogenesis inhibition; caspase activation; cytokine modulation; drug discovery; ethnopharmacology; plant metabolites; marine natural products; molecular docking; oxidative stress; tumor microenvironment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 3449 | Submission Open
Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Aspects of Hematological Malignancies and Benign Hematological Disorders—3rd Edition submission deadline 20 Nov 2025 | 3 articles | Viewed by 3400 | Submission Open
Keywords: myeloproliferative neoplasms; leukemia; lymphoma; multiple myeloma; oxidative stress; inflammation; microbiome; genetics; molecular biology
(This special issue belongs to the Section Molecular Biology)
Female Infertility and Fertility submission deadline 20 Nov 2025 | 3 articles | Viewed by 3317 | Submission Open
Keywords: infertility; embryo; implantation; placenta; endometrium; gynecological endocrinology; assisted reproduction technology; ovaries; inflammation; endometriosis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation
edited by Rossana Scuri
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3254 | Submission Open
Keywords: arteriolar networks organization; blood flow supply; cardiovascular disease; endothelial dysfunction; eNOS regulatory activity; oxidative stress; polyphenols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Basic Mechanisms of Physiological and Pathological Autoimmunity and Their Role in the Development of Autoimmune Diseases
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3170 | Submission Open
Keywords: physiologic autoimmunity; autoimmune diseases; natural immune system; pathologic autoimmunity
(This special issue belongs to the Section Molecular Immunology)
New Therapeutic Targets for Neuroinflammation and Neurodegeneration
edited by Muhammad Sohail Khan and
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3158 | Submission Open
Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations
(This special issue belongs to the Section Molecular Neurobiology)
Recent Developments in Omics Technologies Applied to Oncology Research
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3104 | Submission Open
Keywords: single‑cell genome sequencing; single‑cell epigenome sequencing; single‑cell CRISPR sequencing; imaging mass cytometry; RNAscope; digital spatial profiling; multiplex IHC; multiplex IF; omics technologies
(This special issue belongs to the Section Molecular Oncology)
Endometriosis and Infertility
edited by Ludwig Kiesel
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2841 | Submission Open
Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Omics Science and Research in Human Health and Disease
edited by Elisa De Paolis
submission deadline 20 Nov 2025 | 4 articles | Viewed by 2823 | Submission Open
Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics
(This special issue belongs to the Section Molecular Biology)
TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer submission deadline 20 Nov 2025 | 1 articles | Viewed by 2781 | Submission Open
Keywords: TGF-beta; fibrosis; inflammation; cancer; immune cells; fibroblasts; EMT; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Antioxidant and Antibacterial Properties of Phytochemicals
edited by Dalia Urbonaviciene and Vytaute Starkute
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2753 | Submission Open
Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Involvement of Neuroinflammatory Processes in Psychiatric Conditions
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2712 | Submission Open
Keywords: neuroinflammation; glia; chemokine; cytokine; psychiatry disorder; motivation; learning; behavior; mental illness; psychopharmacology
(This special issue belongs to the Section Molecular Neurobiology)
Microbial Infections and Novel Biological Molecules for Treatment
edited by Matthew Cheesman
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2442 | Submission Open
Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus
(This special issue belongs to the Section Molecular Microbiology)
Plant Response to Drought, Heat, and Light Stress
edited by Mengzhu Lu and Shijiang Cao
submission deadline 20 Nov 2025 | 4 articles | Viewed by 2410 | Submission Open
Keywords: plant stress response; molecular biology techniques; bioinformatics; genetic mechanisms; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 2408 | Submission Open
Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics
(This special issue belongs to the Section Molecular Immunology)
Metabolomics in the Field of Autoimmune Diseases submission deadline 20 Nov 2025 | 2 articles | Viewed by 2370 | Submission Open
Keywords: metabolomics; proteomics; genomics; transcriptomics; biomarkers; autoimmune diseases; inflammatory diseases; nuclear magnetic resonance spectroscopy; mass spectrometry; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Protein Dynamics, Binding and Allostery submission deadline 20 Nov 2025 | 1 articles | Viewed by 2284 | Submission Open
Keywords: proteins dynamics; enzyme catalysis; conformational changes; allosteric regulation; signal transduction; neurodegenerative disorders; cancer; computational methods; therapeutic interventions
(This special issue belongs to the Section Biochemistry)
Multi-Omics Analysis and Application of Plant Natural Products (2nd Edition)
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 2280 | Submission Open
Keywords: omics; plant components; bioactivity; signaling; pathway; target; mechanism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases
edited by and Anna Lass
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2196 | Submission Open
Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances and Perspectives of Lung Disease: 2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2196 | Submission Open
Keywords: lung disease; inflammation; regeneration; infection; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Perspectives on Virus–Host Interactions
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2149 | Submission Open
Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies
(This special issue belongs to the Section Molecular Microbiology)
New Cellular and Molecular Insights into Glaucoma submission deadline 20 Nov 2025 | 1 articles | Viewed by 2114 | Submission Open
Keywords: neuroinflammation; microglia; macroglia; retinal ganglion cells; therapeutical approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment—2nd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2091 | Submission Open
Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Molecular Basis of Plant–Microbe Interactions submission deadline 20 Nov 2025 | 3 articles | Viewed by 2090 | Submission Open
Keywords: plant immune and defense responses; microbe and microbiome function; microbial biodiversity; abiotic and biotic stress mitigation; gene regulatory mechanisms; plant hormones in plant– microbe interactions; molecular mechanisms of plant growth and microbe interactions; chemical communication in plant– microbe interactions; microbe effects on fruit quality; OMICs approaches (metagenomics; metatranscriptomics; epigenomics; transcriptomics; metabolomics); bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Synthesis of Advanced Polymer Materials, 3rd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 2065 | Submission Open
Keywords: polymer synthesis; polymer chemistry; coordination polymerization; organometallic catalysts; polyolefin; degradable polymer materials; green and sustainable polymeric materials; homogeneous polymerization; heterogeneous polymerization
(This special issue belongs to the Section Macromolecules)
Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis submission deadline 20 Nov 2025 | 1 articles | Viewed by 2012 | Submission Open
Keywords: molecular pathogenesis; renal cell carcinoma; genomic profiling; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synapse Dynamics: From Molecular Mechanisms to Functional Plasticity
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1878 | Submission Open
Keywords: synaptic plasticiy; neuronal transmitters; molecular dynamics; neuronal networks; dendritic spines; synapse formation; synaptic vesicles; active zones; axonal transport
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Semiconductor Materials
edited by Tarek Hidouri
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1785 | Submission Open
Keywords: optoelectronics; hybrid materials; power devices; III– V materials; advanced characterization; modeling; molecular advances; semiconductors; biophysics
(This special issue belongs to the Section Materials Science)
Targeted Therapies and Molecular Methods in Cancer, 3rd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1738 | Submission Open
Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook
edited by Alfredo Cappariello
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1714 | Submission Open
Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets
edited by Jue Wang
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1713 | Submission Open
Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular Oncology)
Molecular Biology of Soybean
edited by Zhengjun Xia
submission deadline 20 Nov 2025 | 3 articles | Viewed by 1691 | Submission Open
Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction
(This special issue belongs to the Section Molecular Plant Sciences)
Cardiovascular Diseases: From Pathology to Therapeutics
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1625 | Submission Open
Keywords: cardiovascular diseases; pathologies; cardiac progenitor cells; molecular pathways; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tissue Engineering Related Biomaterials: Progress and Challenges
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1620 | Submission Open
Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors
(This special issue belongs to the Section Materials Science)
Natural Products and Synthetic Compounds for Drug Development: 3rd Edition
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1613 | Submission Open
Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease
(This special issue belongs to the Section Molecular Pharmacology)
Peptides and Peptidomimetics for Targeting Protein-Protein Interactions submission deadline 20 Nov 2025 | 1 articles | Viewed by 1557 | Submission Open
Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC
(This special issue belongs to the Section Biochemistry)
Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease
edited by Sophia Lavrentiadou
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1516 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models
(This special issue belongs to the Section Molecular Neurobiology)
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