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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Breast Cancer: From Pathophysiology to Novel Therapies, 2nd Edition

edited by Jennifer Sims-Mourtada

submission deadline 30 Jun 2026 | Viewed by 18 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

KCTD Proteins in Cellular Processes Regulation: Advances and Challenges

edited by

Giovanni Pecoraro

submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open

Keywords: KCTD proteins; cancer biology; cell signaling pathway; ubiquitination; genetic disorder; protein–protein interaction; developmental biology; protein stability; gene expression; new therapeutic target

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Diabetic Nephropathy

edited by

Natalija Filipović

submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open

Keywords: diabetic nephropathy; hyperglycemia; insulin resistance; oxidative stress; mitochondrial dysfunction; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Smart and Sustainable Delivery Systems for Natural Compounds in Health and Nutrition

edited by Raffaele Conte

submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open

Keywords: natural bioactive compounds; smart delivery systems; sustainable nutrition; biopolymer-based carriers; microfluidics and green technologies; controlled and targeted release; functional foods and nutraceuticals; one health approach

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mediators at the Crossroads of Microbes, the Microbiome, and Cancer

edited by

Syed Azmal Ali

submission deadline 30 Jun 2026 | Viewed by 17 | Submission Open

Keywords: molecular mediators; microbiome-cancer interface; proteomics; multi-omics; functional characterization

(This special issue belongs to the Section Molecular Microbiology)

Characterization and Biological Function of Marine Biopolymers

edited by

Zahira Belattmania

submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open

Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources

(This special issue belongs to the Section Materials Science)

Molecular and Bioactive Properties of Novel and Functional Food Ingredients

edited by

Ewelina Zielińska

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: functional food; bioactive compounds; novel food; molecular properties; peptides; edible insects; metabolomics; health-promoting ingredients; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant and Lichen Metabolites: Characterization and Applications

edited by

Agnieszka Hanaka

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: phytochemicals; secondary metabolites; bioactive compounds; bioactivity evaluation; synthesis optimization; metabolite application; metabolite extraction; elicitors; stress physiology; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Adipose Tissue Dysfunction

edited by

Stefano Quarta

submission deadline 30 Jun 2026 | Viewed by 14 | Submission Open

Keywords: adipose tissue dysfunction; adipogenesis; immunometabolism and adipokines; mitochondrial dysfunction; extracellular vesicles; fibrosis and ECM remodeling; lipid metabolism; browning and beigeing; metabolic biomarkers and therapeutic targets; adipose-derived stem cells

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Perspectives and Challenges in the Mechanisms, Diagnosis and Management of Skin Diseases

edited by

Emanuela Bastonini

, Daniela Kovacs and

Giorgia Cardinali

submission deadline 30 Jun 2026 | Viewed by 14 | Submission Open

Keywords: skin diseases; precision medicine; molecular pathogenesis; regenerative medicine; lipidomics; targeted biologics; inflammatory skin diseases; skin cancers; skin aging; gut– skin axis; skin regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Bioactive Compounds in Cardiovascular and Neurological Diseases

edited by

Paul-Mihai Boarescu

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: inflammation; oxidative stress; bioactive compounds; cardiovascular diseases; neurological diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Inflammasome Signaling

edited by

Soren Hayrabedyan

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome

(This special issue belongs to the Section Biochemistry)

Thyroid Disease: From Molecular Mechanisms to Diagnosis and Therapeutic Advances

edited by

Mariana Lorena Tellechea

and Juan Nicola

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: thyroid disease; hypothyroidism; hyperthyroidism; autoimmune thyroid disease; thyroid nodules; thyroid cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exosomes and Extracellular Vesicles in Health and Diseases: 4th Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Insights into Endothelial Biology and Metabolism

edited by

Hemant Giri

submission deadline 30 Jun 2026 | Viewed by 11 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; vascular biology; endothelial migration; angiogenesis; vascular permeability; shear stress; microvascular and macrovascular remodeling; leukocyte trafficking; mitochondrial function

(This special issue belongs to the Section Molecular Biology)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by Adelina-Gabriela Niculescu and

Ariana Hudita

submission deadline 30 Jun 2026 | Viewed by 11 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

Thyroid Hormone Signaling: Mechanisms and Pathophysiological Implications

edited by María Laura Barreiro Arcos and Horacio Eduardo Romeo

submission deadline 30 Jun 2026 | Viewed by 10 | Submission Open

Keywords: thyroid hormones; mitochondrial function; oxidative stress; redox signaling; metabolic disorders; immune modulation; cardiovascular pathology; neurodevelopment and aging; cancer progression

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders

edited by

Dalia Marija Kopustinskiene

submission deadline 30 Jun 2026 | Viewed by 10 | Submission Open

Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetics- and Genomics-Based Wheat Improvement and Breeding

edited by Jian Ma

submission deadline 30 Jun 2026 | Viewed by 10 | Submission Open

Keywords: wheat crop; germplasm; genetics; genomics; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Plant Breeding and Biotechnology: From Lab to Field

edited by

Wenlong Bao

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: crop improvement; genetic transformation; omics approaches; plant metabolites; plant resistance; plant breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Autophagy in Physiology and Pathophysiology: Recent Advances

edited by

María Isabel Colombo

and Claudio Marcelo Fader

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: macroautophagy; microautophagy; chaperone-mediated autophagy (CMA); autophagy-related genes (ATG); xenophagy; mitophagy; pexophagy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Cotton Breeding and Genetics

edited by

Yanpeng Zhao

submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open

Keywords: cotton genomics; molecular breeding; gene regulation; abiotic stress tolerance; fiber quality improvement; disease resistance; genetic engineering; marker-assisted selection; transcriptomics; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Gut Microbiome Regulation in Immunity and Inflammation

edited by Lei Deng

submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open

Keywords: gut microbiome; adaptive immunity; IBD; inflammation; innate immunity; enteric infections; salmonella; intestine barrier; mucosal immunity

(This special issue belongs to the Section Molecular Microbiology)

Metabolic Features of Breast Cancer: From Understanding Heterogeneous Biology to Developing New Therapies

edited by

Lyudmila Bel'skaya

submission deadline 30 Jun 2026 | Viewed by 7 | Submission Open

Keywords: breast cancer; heterogeneity; metabolic processes; metabolites; proteins; gene expression; diagnosis; prognosis; treatment response

(This special issue belongs to the Section Molecular Oncology)

New Molecular Perspectives on Diabetic Retinopathy

edited by Martina Tomić and

Tomislav Bulum

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: diabetic retinopathy; diabetes; complications; vascular endothelial growth factor; retina; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research in Animal Reproduction

edited by

He Huang

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: animal reproduction; molecular regulation; spermatogenesis; embryonic development; epigenetics; reproductive hormones; oogenesis; environmental factors

(This special issue belongs to the Section Molecular Biology)

Rare Diseases Associated with Short Stature: Genetics, Pathogenesis and Therapy, 2nd Edition

edited by

Michal Ordak

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: skeletal disorders; dwarfism; skeletal dysplasias; short stature; biomarkers; mutations; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Organoid Models: Advancing the Study of Disease Mechanisms and Nutritional Regulations

edited by

Xi Lin

and Pinghuang Liu

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: organoids; disease mechanisms; nutritional regulation; disease modeling; stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interactions Between Microbes and Hosts: Physiology, Pathology and Treatment—Second Edition

edited by

Emira D’Amico

submission deadline 30 Jun 2026 | Viewed by 5 | Submission Open

Keywords: microbial infection; microbes– host interaction; virulence factors; molecular and cell biology; antimicrobial therapy; antibiotics; antimicrobial peptides; resistance mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications

edited by Analia G. Karadayian

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Updates on Synthetic and Natural Antioxidants (2nd Edition)

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Pathobiology, Diagnosis, and Treatment of Neurodegenerative Diseases

edited by

Saak V. Ovsepian

, Stergios Boussios and

Jaison Jeevanandam

submission deadline 30 Jun 2026 | Viewed by 4 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; dementia with Lewy bodies; motor neuron diseases; molecular pathobiology; diagnosis; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Bridging Basic and Clinical Science: Shared Molecular and Metabolic Mechanisms in Preeclampsia, Gestational Diabetes and Gestational Weight Gain

edited by

Reyna Sámano

, Hector Borboa-Olivares, Verónica Zaga-Clavellina and

Gabriela Chico-Barba

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: preeclampsia; gestational diabetes; gestational weight gain; metabolic mechanisms; molecular pathways; placental biology; maternal– fetal interface; biomarkers; insulin resistance; inflammation; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 30 Jun 2026 | Viewed by 2 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Advanced Biomaterials for Tissue Regeneration

edited by

Liviu Duta

and

Valentina Grumezescu

submission deadline 30 Jun 2026 | Submission Open

Keywords: biomaterials; tissue regeneration; molecular mechanisms; cell-instructive scaffolds; injectable hydrogels; ECM-mimetic materials; bioactive ceramics; bioactive surface coatings; mechanotransduction/mechanobiology; immunomodulation; angiogenesis and vascularization; biofabrication (3D/4D printing)

(This special issue belongs to the Section Materials Science)

Animal‐Derived Bioactive Peptides as Next‐Generation Therapeutics

edited by

Mariana S. Castro

and

Wagner Fontes

submission deadline 30 Jun 2026 | Submission Open

Keywords: venom-derived peptides; animal toxins; antimicrobial peptides; immunomodulation; wound healing; antiparasitic agents; peptide‐based therapeutics; skin secretions

(This special issue belongs to the Section Molecular Toxicology)

Applications and Advances of Organic Synthesis in the Design of Antiparasitic, Antiviral, and Anticancer Drugs

edited by

Sergio Hernán Szajnman

and Juan B. Rodriguez

submission deadline 30 Jun 2026 | Submission Open

Keywords: antiparasitic agents; antiviral agents; chagas disease; toxoplasmosis; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Natural Products for Antiviral Drug Discovery

edited by

Thao Quyen Cao

submission deadline 30 Jun 2026 | Submission Open

Keywords: bioactive natural compound; secondary metabolites; antiviral activity; molecular mechanisms; metabolomic-guided discovery; natural antivirals; food-derived bioactivity; AI-assisted prediction of antiviral natural products; microbe-derived antiviral metabolites; marine-derived antiviral metabolites

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biomarkers and Therapeutic Targets for Acute Liver and Kidney Injury

edited by

Gang Ye

submission deadline 30 Jun 2026 | Submission Open

Keywords: acute liver injury; acute kidney injury; multi omics technology; network pharmacology; molecular biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cardiovascular and Vascular Biology

edited by

Woongbi Jang

submission deadline 30 Jun 2026 | Submission Open

Keywords: cardiovascular diseases; vascular biology; molecular mechanisms; biomarkers; endothelial dysfunction; translational medicine

(This special issue belongs to the Section Molecular Biology)

Molecular and Biochemical Advances in Kidney Diseases and Genetics

edited by

Silvio R. De Luka

submission deadline 30 Jun 2026 | Submission Open

Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Molecular Design to Functional Performance: Advanced Materials for Energy and Environmental Technologies

edited by

Abu Talha Aqueel Ahmed

submission deadline 30 Jun 2026 | Submission Open

Keywords: molecular design; molecular engineering; functional materials; organic– inorganic hybrid materials; nanostructured materials; morphology engineering; surface and interface chemistry; defect and vacancy engineering; electrocatalysis; photocatalysis; photoelectrochemical systems; energy generation and conversion; energy harvesting; energy storage; supercapacitors; lithium-ion batteries (LIBs); sodium-ion batteries (SIBs); oxygen evolution reaction (OER); hydrogen evolution reaction (HER); overall water splitting; methanol oxidation reaction (MOR); urea oxidation reaction (UOR); advanced oxidation processes (AOPs); pollutant removal and degradation; hazardous material degradation; water purification; environmental remediation; charge transfer and reaction kinetics; structure– property– performance relationships; in situ and operando spectroscopy; electrochemical characterization; density functional theory (DFT); molecular modeling and simulation; reaction mechanisms; catalyst stability and reconstruction; sustainable and green materials

(This special issue belongs to the Section Materials Science)

Cellular Immunotherapy in Cancer: Current Trends and Future Directions

edited by

Vahid Vahedian

submission deadline 30 Jun 2026 | Submission Open

Keywords: cellular immunotherapy; CAR-T cells; CAR-NK cells; CAR-macrophages; tumor-infiltrating lymphocytes (TILs); immune receptor signaling; tumor microenvironment; CRISPR/Cas9 genome editing; precision cancer immunotherapy; translational immuno-oncology

(This special issue belongs to the Section Molecular Immunology)

The Role of Vitamin B6 in Metabolism and Genome Stability

edited by

Fiammetta Verni

submission deadline 30 Jun 2026 | Submission Open

Keywords: vitamin B6; PLP; DNA damage; metabolism

(This special issue belongs to the Section Molecular Biology)

Biochemistry and Biophysics Tools for Peptide and Protein Research

edited by

Wenqi Li

submission deadline 30 Jun 2026 | Submission Open

Keywords: protein– protein interactions; peptide therapeutics development; biosensor and labeling technologies; high-throughput screening; mass spectrometry proteomics; protein dynamics and folding; single-molecule biophysics; analytical ultra-centrifugation; computational protein design; structural biology techniques

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD)

edited by Shirin Pourteymour

submission deadline 30 Jun 2026 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); hepatic lipid metabolism; immunometabolism; inflammation and innate immunity; mitochondrial dysfunction in MASLD; genetic and epigenetic regulation; inter-organ communication; fibrosis and disease progression; translational liver biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Molecular Ecology and Genomic Perspectives

edited by

Peng Zhao

submission deadline 1 Jul 2026 | Viewed by 271 | Submission Open

Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Physiopathological Role of Hypoxia

edited by

Michele Aventaggiato

submission deadline 10 Jul 2026 | Viewed by 62 | Submission Open

Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breast Cancer: From Molecular Mechanism to Therapeutic Strategy

edited by

Anna Makuch-Kocka

submission deadline 10 Jul 2026 | Viewed by 58 | Submission Open

Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Structure and Characterization of Optical Materials

edited by

Andrzej Kruk

submission deadline 10 Jul 2026 | Viewed by 40 | Submission Open

Keywords: luminescence; structure modification; spectroscopy; measurement techniques; Kerr effect; Faraday effects; doping; molecular structure

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Displaying special issue 3101-3150 on page 63 of 66.

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