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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unraveling Bioactive Peptides: Structure, Function, and Applications

edited by

Sara Elsa Aita

submission deadline 20 Jun 2026 | Viewed by 335 | Submission Open

Keywords: bioactive peptides; peptide structure– activity relationship; peptidomics; bioactivity assays; human health

(This special issue belongs to the Section Macromolecules)

Molecular Mechanisms of Biotic and Abiotic Stress Responses in Trees

edited by

Chenghao Li

submission deadline 20 Jun 2026 | Viewed by 331 | Submission Open

Keywords: drought stress; nutrient deficiency; salinity stress; pathogen defense; transcriptional regulation; epigenetic modifications; signal transduction; bioinformatics & multi-omics analysis; breeding for stress resilience

(This special issue belongs to the Section Molecular Plant Sciences)

From Discovery to Clinic: Overcoming Barriers in Antimicrobial Peptide Development

edited by José M. Pérez De la Lastra

submission deadline 20 Jun 2026 | Viewed by 329 | Submission Open

Keywords: antimicrobial peptides (AMPs); translational challenges; in vivo efficacy; drug delivery and formulation; computational approaches; pharmacokinetics; toxicity prediction; antibiotic resistance; animal models; nanotechnology

(This special issue belongs to the Section Molecular Microbiology)

Advanced Research on Antioxidant Activity

edited by Agnieszka Filipek

submission deadline 20 Jun 2026 | Viewed by 325 | Submission Open

Keywords: antioxidants; advanced mechanisms of action; signaling pathways; molecular mechanism; biologically active compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by

Amelia Salimonti

submission deadline 20 Jun 2026 | Viewed by 323 | Submission Open

Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Mechanobiology of Regeneration

edited by

Christopher Robinson

and Timothy R. Deer

submission deadline 20 Jun 2026 | Viewed by 317 | Submission Open

Keywords: mechanotransduction; regeneration; stem cells; extracellular matrix; tissue repair

(This special issue belongs to the Section Molecular Biophysics)

Male Reproduction: Unveiling the Molecular Revolution

edited by

Anthony Archibong

submission deadline 20 Jun 2026 | Viewed by 314 | Submission Open

Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Trends in Green Synthesis of Nanomaterials

edited by Rocío Redón

submission deadline 20 Jun 2026 | Viewed by 310 | Submission Open

Keywords: nanoparticles; cytotoxicity; drug delivery; nanomaterials; green synthesis

(This special issue belongs to the Section Molecular Nanoscience)

Micro/Nano-Structure Regulation of Two-Dimensional Materials

edited by

Ning Wang

submission deadline 20 Jun 2026 | Viewed by 300 | Submission Open

Keywords: 2D materials; micro/nano-engineering; structure– property relationships

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Diagnostics in Hereditary Hemolytic Anemias

edited by Joan-Lluís Vives-Corrons

submission deadline 20 Jun 2026 | Viewed by 295 | Submission Open

Keywords: anemia; red blood cell erythropoiesis; membranopathies ; erythro enzymopathies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives in Protein Structure

edited by

Csaba Magyar

submission deadline 20 Jun 2026 | Viewed by 293 | Submission Open

Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins

(This special issue belongs to the Section Molecular Biophysics)

Epigenetic Alterations in Hepatocellular Carcinoma

edited by

Yonghwan Shin

submission deadline 20 Jun 2026 | Viewed by 287 | Submission Open

Keywords: hepatocellular carcinoma (HCC); epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs epigenetic biomarkers; cancer progression

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 20 Jun 2026 | Viewed by 286 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound

edited by Alicia Paz

submission deadline 20 Jun 2026 | Viewed by 282 | Submission Open

Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives

(This special issue belongs to the Section Molecular Microbiology)

From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives

edited by Kyoko Koshibu

submission deadline 20 Jun 2026 | Viewed by 278 | Submission Open

Keywords: psychoactive alkaloids; neuropharmacology; bioactive compounds; performance enhancement; addiction; translational research; cognitive modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Engineering in Insoluble Antibacterial Particle for Medical Devices

edited by Ole T. Jensen

submission deadline 20 Jun 2026 | Viewed by 265 | Submission Open

Keywords: antibacterial; quaternary ammonium silica particles; bactericidal mechanism; antibacterial particle; medical devices

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 20 Jun 2026 | Viewed by 263 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanobiotechnology: Breaking Barriers in Phytomedicine

edited by

Maria Aparecida Medeiros Maciel

submission deadline 20 Jun 2026 | Viewed by 263 | Submission Open

Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Studies of DNA Strand Exchange

edited by

Masayuki Takahashi

submission deadline 20 Jun 2026 | Viewed by 260 | Submission Open

Keywords: DNA strand exchange; homologous recombination: RecA-family recombinases; drug resistance: drug development against recombinases; evolution

(This special issue belongs to the Section Molecular Biophysics)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 20 Jun 2026 | Viewed by 243 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Molecular and Adaptive Mechanisms in Plant Genetics

edited by

Gennaro Lettieri

submission deadline 20 Jun 2026 | Viewed by 217 | Submission Open

Keywords: forest genetics; breeding techniques; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Anticancer Drugs: Current Status and Future Directions

edited by

Mariano Martínez-Vázquez

submission deadline 20 Jun 2026 | Viewed by 204 | Submission Open

Keywords: anticancer drugs; hybrids; combinations; nanoparticles

(This special issue belongs to the Section Molecular Pharmacology)

Functional Epigenomics in Plants

edited by

Slimane Khayi

submission deadline 20 Jun 2026 | Viewed by 148 | Submission Open

Keywords: epigenomics; crop improvement; epigenetic variation; functional genomics; DNA methylation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Genetic Mechanism of Stress Resistance in Plants

edited by Mohammad Nurul Matin

submission deadline 21 Jun 2026 | 1 articles | Viewed by 2013 | Submission Open

Keywords: stress response and resistance; environmental adaptation; abiotic and biotic stress; gene regulation network; functional genomics; molecular signalling pathways; CRISPR/cas systems; epigenetic regulation; transcriptome profiling; metabolic reprogramming; stress-responsive genes

(This special issue belongs to the Section Molecular Genetics and Genomics)

Functions and Applications of Natural Products: 2nd Edition

edited by

Seung-Hong Lee

submission deadline 25 Jun 2026 | 6 articles | Viewed by 8129 | Submission Open

Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Melanoma: Molecular Mechanism and Therapy, 2nd Edition

edited by

Balázs Margit

submission deadline 25 Jun 2026 | 3 articles | Viewed by 3567 | Submission Open

Keywords: melanoma progression; melanoma metastasis; molecular background; targeted therapies; immunotherapy; acquired drug resistance; prognostic and predictive markers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Mitochondrial Function in Human Health and Disease: 3rd Edition

edited by

Yumay Chen

submission deadline 25 Jun 2026 | 3 articles | Viewed by 2168 | Submission Open

Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT

(This special issue belongs to the Section Biochemistry)

Molecular Research in Pregnancy-Related Complications

edited by Kallirhoe Kalinderi

submission deadline 25 Jun 2026 | Viewed by 538 | Submission Open

Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)

edited by

Ehsan Gharib

submission deadline 25 Jun 2026 | Viewed by 250 | Submission Open

Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Progression of Gut Microbiota—2nd Edition

edited by

Emina Pustijanac

submission deadline 25 Jun 2026 | Viewed by 223 | Submission Open

Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Glycosylation in Tumor Microenvironment: Roles, Mechanisms and Interventions

edited by

Koichi Furukawa

submission deadline 25 Jun 2026 | Viewed by 202 | Submission Open

Keywords: glycoproteins; glycolipids; signaling; cell– cell interaction; cell membrane

(This special issue belongs to the Section Molecular Oncology)

Advances in Materials for Water Treatment and Metal/Nutrient Recovery

edited by

Aurora Pat-Espadas

submission deadline 25 Jun 2026 | Viewed by 167 | Submission Open

Keywords: water treatment; wastewater treatment; recalcitrant pollutants; metal recovery; nutrient recovery; molecularly engineered materials; functional materials; adsorption and remediation

(This special issue belongs to the Section Materials Science)

Cancer Stem Cells: Molecular Mechanisms and Therapeutic Targeting

edited by Pablo Pérez-Moreno

submission deadline 25 Jun 2026 | Viewed by 164 | Submission Open

Keywords: cancer stem cells; CSCs clinical biomarkers; CSCs as therapeutic targets; cancer cell biology of CSCs; prognosis and CSCs; molecular biology and CSCs

(This special issue belongs to the Section Molecular Oncology)

Current Research on Cancer Biology and Therapeutics: Fourth Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 29 Jun 2026 | 9 articles | Viewed by 11473 | Submission Open

Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists

(This special issue belongs to the Section Molecular Oncology)

Plant Growth: Molecular Mechanisms

edited by

Zulfiqar Ali Sahito

and

Afsheen Zehra

submission deadline 29 Jun 2026 | Viewed by 365 | Submission Open

Keywords: plant growth; hormonal crosstalk; epigenetics; CRISPR/Cas9 genome editing technologies; metabolomics; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

State-of-the-Art Molecular Immunology in Chile, 2nd Edition

edited by

Marcela Hernandez Ríos

Juan C. Aguillon

, María Rosa Bono,

Nicolas Dutzan

Rolando Vernal

and

Leandro J. Carreño

submission deadline 30 Jun 2026 | 8 articles | Viewed by 21824 | Submission Open

Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile

(This special issue belongs to the Section Molecular Immunology)

Latest Reviews in Molecular Plant Science 2025

edited by

Maoteng Li

and

Jinsong Bao

submission deadline 30 Jun 2026 | 6 articles | Viewed by 16163 | Submission Open

Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 30 Jun 2026 | 14 articles | Viewed by 16004 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 30 Jun 2026 | 5 articles | Viewed by 11427 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 30 Jun 2026 | 7 articles | Viewed by 10589 | Submission Open

Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies

edited by

Lorenzo Belluomini

submission deadline 30 Jun 2026 | 4 articles | Viewed by 10235 | Submission Open

Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations

(This special issue belongs to the Section Molecular Oncology)

Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies

edited by

Hongqun Liu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9660 | Submission Open

Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Developments in Glioblastoma Research and Therapy: 2nd Edition

edited by

Aleksandra Majchrzak-Celińska

submission deadline 30 Jun 2026 | 6 articles | Viewed by 9529 | Submission Open

Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors

(This special issue belongs to the Section Molecular Neurobiology)

Wnt/β-Catenin Signaling in Cancer

edited by

Teresa Catalano

and

Gitana Maria Aceto

submission deadline 30 Jun 2026 | 1 articles | Viewed by 8830 | Submission Open

Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

The Natural Products for Cancer Therapy

edited by María Jesus Rodríguez-Yoldi

submission deadline 30 Jun 2026 | 2 articles | Viewed by 7989 | Submission Open

Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Preclinical and Translational Research in Thyroid Cancer

edited by

Marialuisa Appetecchia

and

Giulia Puliani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 6974 | Submission Open

Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Psychedelics and Mental Disorders: From Molecular Mechanisms to Therapies Potential

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 30 Jun 2026 | 2 articles | Viewed by 6286 | Submission Open

Keywords: psychedelics; drug-induced neurotoxicity; therapeutic potential; mental disorders; neuroprotective mechanisms; adult neurogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Hormone Receptor in Breast Cancer: 2nd Edition

edited by

Rocío García-Becerra

submission deadline 30 Jun 2026 | 3 articles | Viewed by 4889 | Submission Open

Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors

(This special issue belongs to the Section Molecular Oncology)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4880 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 4382 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

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