DNA Methylation in Cancer: Progress and Challenges
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 182
Special Issue Editor
Interests: genomics; epigenomics; melanomas; human cancer; PAX genes; transcriptomic
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
DNA methylation abnormalities are frequent in cancer, including altered cytosine methylation in CpG dinucleotide residues and other pairs, such as CpA, although much less is known about the latter. The impact of alterations in DNA methylation on cancer onset and progression is very topical, especially in relation to aggressive cancer characteristics like metastasis, drug-resistance, altered anti-tumor immune responses, and enhanced tumor growth. The technologies for investigating genome-wide methylation have rapidly evolved in recent years, including bisulfite sequencing approaches. These developments could enhance this field, potentially allowing a higher sensitivity for detecting methylation alterations in smaller amounts of DNA.
In this Special Issue, we are looking to receive review articles and original research shaping our understanding of the role of DNA methylation alterations in cancer, as well as contributions which could potentially influence future research directions in this important area of cancer biology.
Prof. Dr. Michael Eccles
Guest Editor
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Keywords
- DNA methylation
- cancer
- hypomethylation
- hypermethylation
- epigenetics
- tumor onset
- tumor progression
- technologies
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