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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Male Infertility and Fertility

edited by

Mariaimmacolata Preianò

submission deadline 29 Nov 2025 | Viewed by 40 | Submission Open

Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cardiac Disease

edited by

Daniela Rossin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3015 | Submission Open

Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Diseases: Aging and Other Risk Factors

edited by

Silvia Liskova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2935 | Submission Open

Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Considerations in the Evolving Treatment Landscape of Hormone-Sensitive and Hormone-Resistant Prostate Cancer

edited by

Pierre Tennstedt

submission deadline 30 Nov 2025 | Viewed by 270 | Submission Open

Keywords: prostate cancer; hormone-sensitive prostate cancer; HSPC; hormone-resistant prostate cancer; HRPC; metastasis; androgen deprivation therapy; docetaxel; androgen receptor axis-targeted therapy agents; ARAT; abiraterone; enzalutamide; apalutamide; talazoparib; genetic; biomarker; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 30 Nov 2025 | Viewed by 241 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Biomaterials for Bone Treatment, Replacement and Regeneration: Focus on Regeneration and Inflammation

edited by

Mike Barbeck

submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open

Keywords: biomaterials ; bone substitute ; inflammation ; foreign body response ; bone regeneration

(This special issue belongs to the Section Materials Science)

Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia

edited by Mark Slevin

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: lipid metabolism; energy metabolism; obesity; metabolic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Nematodes Management

edited by

Giada D'Errico

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Pediatric Neuromuscular Disorders

edited by

Tai-Heng Chen

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: pediatric neuromuscular disorders; gene therapy; biomarkers; molecular pathophysiology; muscular dystrophy; motor neuron disease; translational medicine; neuromuscular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural Codes of Sphingolipids and Their Involvement in Diseases

edited by

Sandro Sonnino

and

Elena Chiricozzi

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Lipopolysaccharides

edited by

Satish Raina

and

Gracjana Klein

submission deadline 30 Nov 2025 | Viewed by 22 | Submission Open

Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases

(This special issue belongs to the Section Molecular Biology)

Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics

edited by

Georgios Pantouris

submission deadline 30 Nov 2025 | Viewed by 22 | Submission Open

Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity

(This special issue belongs to the Section Molecular Oncology)

DNA Repair, Genome Stability and Diseases

edited by Melike Caglayan

submission deadline 30 Nov 2025 | Viewed by 20 | Submission Open

Keywords: DNA damage; DNA repair; genomic stability; targeted therapy; biomarkers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition

edited by Sanja Dabelić

submission deadline 30 Nov 2025 | Viewed by 17 | Submission Open

Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics

(This special issue belongs to the Section Macromolecules)

ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 30 Nov 2025 | Viewed by 16 | Submission Open

Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Non-Coding RNAs as Key Regulators in Human Disease Processes

edited by

Beatrice Polini

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 30 Nov 2025 | Viewed by 13 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Canonical and Noncanonical Inflammasomes in Inflammation and Diseases

edited by

Young-Su Yi

submission deadline 30 Nov 2025 | Viewed by 12 | Submission Open

Keywords: canonical; noncanonical; inflammasome; inflammation; human diseases; anti-inflammatory therapeutics

(This special issue belongs to the Section Molecular Immunology)

Advances in Targeted Therapies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 30 Nov 2025 | Viewed by 10 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential

edited by

Manuel Benedikt Graeber

submission deadline 1 Dec 2025 | Viewed by 294 | Submission Open

Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 1 Dec 2025 | Viewed by 62 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 4 Dec 2025 | 4 articles | Viewed by 20386 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biology of Oral Cancer

edited by Rafał Pęksa

submission deadline 10 Dec 2025 | Viewed by 49 | Submission Open

Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 Dec 2025 | 13 articles | Viewed by 10234 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms

edited by

Luigi De Masi

submission deadline 20 Dec 2025 | 10 articles | Viewed by 9340 | Submission Open

Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Bioactives and Inflammation, 2nd Edition

edited by

Juan Gambini

submission deadline 20 Dec 2025 | 5 articles | Viewed by 8459 | Submission Open

Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Updates on Synthetic and Natural Antioxidants

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7126 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Innovations in Polymeric Materials: Exploring Advancements and Applications

edited by

Silvia Vasiliu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6278 | Submission Open

Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment

(This special issue belongs to the Section Materials Science)

RNA Vaccines and Therapeutics: Challenges and Opportunities

edited by

Seong-Wook Lee

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6033 | Submission Open

Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing

(This special issue belongs to the Section Molecular Pharmacology)

Nutrition as a Tool for Modulating Cellular Metabolism

edited by

Francesca Oppedisano

Anna Spagnoletta

and

Salvatore Nesci

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5876 | Submission Open

Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology

(This special issue belongs to the Section Biochemistry)

Diabetes: Advances in Molecular Research

edited by

Alexandra E. Butler

and

Stephen Atkin

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5107 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lymphatic Disorders: From Molecular Mechanisms to Therapies

edited by

Laura Patton

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4823 | Submission Open

Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Redox Homeostasis and Oxidative Stress

edited by

Dimitrios Kouretas

, Zoi Vasiliki Skaperda and

Fotios Tekos

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4457 | Submission Open

Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases

(This special issue belongs to the Section Molecular Pharmacology)

Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition

edited by

Hideo Nakashita

and

Takumi Nishiuchi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3316 | Submission Open

Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition

edited by

Nicoletta Cordani

and

Manfioletti Guidalberto

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2674 | Submission Open

Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations

(This special issue belongs to the Section Molecular Oncology)

Wnt/β-Catenin Signaling in Cancer

edited by

Teresa Catalano

and

Gitana Maria Aceto

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2535 | Submission Open

Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Cytochrome P450 Mechanism and Reactivity

edited by

Samuel De Visser

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2514 | Submission Open

Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition

(This special issue belongs to the Section Biochemistry)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2221 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2057 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health

edited by

Elena Vianello

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1791 | Submission Open

Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Allergic Diseases: Molecular Insights into Immunotherapy

edited by Stefania Nicola

submission deadline 20 Dec 2025 | 3 articles | Viewed by 1674 | Submission Open

Keywords: component resolved diagnosis; allergen immunotherapy; molecular diagnostic; basophil activation test; anaphylaxis; allergy diagnosis; in vitro tests; in vivo tests; skin prick test

(This special issue belongs to the Section Molecular Immunology)

Integrating Molecular Insights on Plant Microbes and Insect Pests

edited by

Xifeng Wang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1434 | Submission Open

Keywords: pathogenic microbes; resistance mechanisms; signaling pathways; omics technologies; plant and insect interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer

edited by Spyridon Siakavellas and

Stavros P. Papadakos

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1396 | Submission Open

Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections

edited by

Maria D'Accolti

and

Elisabetta Caselli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1112 | Submission Open

Keywords: microbial infections; AMR; molecular biology; One Health; microbiome

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Photosystem I (Second Edition)

edited by

Stefano Santabarbara

and

Gary Hastings

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1020 | Submission Open

Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Reproductive Physiology and Endocrinology

edited by

Kamil Gill

submission deadline 20 Dec 2025 | 2 articles | Viewed by 911 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 20 Dec 2025 | 1 articles | Viewed by 883 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Rhizobia

edited by