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The Role of Bioactive Compounds in Human Health and Disease: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 750

Special Issue Editor


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Special Issue Information

Dear Colleagues,

A bioactive compound is a compound that has an effect on a living organism, tissue or cell, usually demonstrated by basic research in vitro or in vivo in the laboratory. Bioactive compounds are commonly derived from plants, and can be synthetically produced. Examples of plant bioactive compounds are carotenoids, polyphenols, or phytosterols. Bioactive compounds from plants are vital for human health and disease, which are gaining wide attention for their anticancer activities and anti-inflammatory activity, etc., yet their significance remains underappreciated.

This Special Issue aims to provide a platform for molecular mechanistic research and potential medical applications on bioactive compound with a special focus on inhibition of inflammation, tumor growth and metastasis, enhancement of cancer therapeutic efficacy or amelioration of the associated adverse effects. Research and develop hyphenated technological platforms of metabolomics for deciphering the biosynthetic pathway(s) of specific bioactive phytocompounds in plants.

We warmly welcome your submissions of original papers and reviews based on results from molecular viewpoints.

This Special Issue is supervised by Prof. Dr. Guan-Jhong Huang and assisted by our Guest Editor’ assistant editor Dr. Xingkang Wu xingkang1234@126.com (Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University).

Prof. Dr. Guan-Jhong Huang
Guest Editor

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Keywords

  • cancer
  • inflammation
  • cardiovascular diseases
  • plants
  • bioactive compounds

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Published Papers (1 paper)

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Research

18 pages, 6048 KiB  
Article
(7E)-7,8-Dehydroheliobuphthalmin from Platycladus orientalis L.: Isolation, Characterization, and Hair Growth Promotion
by Zikai Lin, Yan Sun, Chengzhao Li, Xiaowei Zhou, Yuting Guo, Zhenhua Wang and Gang Li
Int. J. Mol. Sci. 2025, 26(11), 5189; https://doi.org/10.3390/ijms26115189 - 28 May 2025
Viewed by 511
Abstract
Androgenetic alopecia (AGA) is a prevalent form of non-scarring hair loss, affecting approximately 32.13% of the population. Seborrheic alopecia is the most frequently observed among its various types, contributing to over 25% of hair loss cases in men. Identifying effective natural compounds or [...] Read more.
Androgenetic alopecia (AGA) is a prevalent form of non-scarring hair loss, affecting approximately 32.13% of the population. Seborrheic alopecia is the most frequently observed among its various types, contributing to over 25% of hair loss cases in men. Identifying effective natural compounds or therapeutic agents that stimulate hair growth remains a key research focus. Platycladus orientalis L., known for its medicinal properties, shows potential in promoting hair darkening and regeneration, although its mechanisms remain unclear. In this study, Fr2 of Platycladus orientalis L. was found to significantly enhance hair growth in mice. Similarly, (7E)-7,8-Dehydroheliobuphthalmin (DHHB) was successfully isolated and purified for the first time through a combination of medium-pressure liquid chromatography and two-dimensional high-performance liquid chromatography. In an alopecia areata (AGA) model using dermal papilla cells (DPCs), DHHB was found to significantly promote cell proliferation and differentiation by down-regulating the expression of androgen receptor (AR) proteins, and activating the Wnt/β-catenin signaling pathway, as compared with the dihydrotestosterone-induced model group. These results indicate that DHHB is a major bioactive compound in Platycladus orientalis L. and represents a promising candidate for promoting hair growth. Full article
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