Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 547
Special Issue Editor
Interests: neurodevelopmental disorder; neurodevelopment; brain development; neurite formation; neuronal migration; spine formation; synapse formation; neural connectivity; electrophysiology; behavior; mouse genetics; autism spectrum disorder
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is crucial to understand the cellular and molecular mechanisms that underlie neurodevelopmental and neurological disorders to develop novel treatments. Indeed, many disorders, such as Alzheimer's disease and autism spectrum disorder, are associated with abnormalities and disruptions in crucial processes and neurobiological functions, such as neural migration, neuronal morphogenesis, and synaptogenesis. Both inherited and de novo mutations may play a significant role in the development of these disorders, with the potential to profoundly affect neurodevelopmental pathways and cellular functions in adulthood. Using advanced techniques, such as CRISPR-Cas9 genome editing and high-throughput sequencing, researchers can unravel the molecular basis contributing to the onset of neurodevelopmental and neurological disorders, thereby identifying potential therapeutic targets.
This Special Issue features original and review articles about cellular and molecular studies on neurodevelopmental and neurological disorders, utilizing current techniques, such as CRISPR/Cas9, multi-omics, etc., in any system, including animal (rodents, flies, worms, fishes, etc.) and human models, gene-modified animals, and human induced pluripotent stem cells (hiPSCs). Topics of interest include, but are not limited to, the following:
- Autism spectrum disorder (ASD);
- Attention deficit hyperactivity disorder (ADHD);
- Schizophrenia;
- Bipolar disorder;
- Intellectual disability (ID);
- Cognitive disorders;
- Alzheimer's disease (AD);
- Parkinson's disease (PD);
- Traumatic brain injury (TBI);
Our interest is in molecular and cellular analyses of pathological features and functions of mutated proteins, including less-of-function molecules and/or gain-of-function molecules. We are also interested in articles that describe how disease-responsible genes and proteins function in normal brain development and function.
This Special Issue is supervised by Dr. Kazuhito Toyooka and assisted by Dr. Liu Xiaonan. We warmly welcome the submission of short communications, original research articles, and review articles.
You may choose our Joint Special Issue in Brain Sciences
Dr. Kazuhito Toyooka
Guest Editor
Manuscript Submission Information
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Keywords
- autism spectrum disorder
- ADHD
- schizophrenia
- intellectual disability
- Alzheimer’s disease
- Parkinson’s disorder
- traumatic brain injury
- epilepsy
- neurodevelopmental disorders
- neurological diseases
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