Antibody Engineering and Therapeutic Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 3178
Special Issue Editor
Interests: therapeutic antibody; cancer immunotherapy; antibody engineering; structure and mechanism of antibody drugs; protein structure
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advances in antibody-mediated therapies have markedly enhanced their clinical efficacy. Cancer immunotherapy has drastically altered the treatment of multiple types of tumors, leading to the approval of monoclonal antibodies for checkpoint inhibition, CAR-T cell therapies, T-cell engagers, and bispecific antibod-ies. Antibody-drug conjugates (ADCs) represent one of the most swiftly blooming therapeutic modalities in oncology, with 12 ADCs approved by the FDA and over 300 currently undergoing clinical investigations.
The design and clinical application of monoclonal antibody (mAb) therapeutics ne-cessitate thoroughly comprehending the intricate relationship between their struc-ture and function. Recent breakthroughs in artificial intelligence (AI) methodologies have made significant progress in the generation of protein sequences and struc-tures, enabling the de novo design of antibodies capable of binding to specific sur-faces of target proteins.
This Special Issue aims to address recent advancements and innovative concepts in the design and application of cutting-edge antibody-mediated therapies, including but not limited to mAb therapeutics, biosimilars, antibody-drug conjugates (ADCs), bispecific and multispecific antibodies, T-cell engagers (TCEs), CAR-T or CAR-NK therapies, nanobodies, immunocytokines, antibody-targeted nanoparticles, antibody structure and mechanism of action, antibody engineering, and AI-driven antibody design. Original papers and review articles are welcome.
Prof. Dr. Yong-Seok Heo
Guest Editor
Manuscript Submission Information
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Keywords
- monoclonal antibody (mAb) therapies
- antibody engineering
- antibody-drug conjugate (ADC)
- chimeric antigen receptor T cell (CAR-T)
- bispecific antibody
- T-cell engager (TCE)
- cancer immunotherapy
- immunocytokine
- AI-driven antibody design
- antibody structure and mechanism of action
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