Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 July 2025) | Viewed by 1253
Special Issue Editor
2. Department of Medical Oncology, Ioannina University Hospital, 455 00 Ioannina, Greece
3. Faculty of Medicine, Health and Social Care, Canterbury Christ Church University, Canterbury CT1 1QU, UK
4. Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London SE1 9RT, UK
5. Medway NHS Foundation Trust, Windmill Road, Gillingham ME7 5NY, Kent, UK
6. AELIA Organization, 9th Km Thessaloniki—Thermi, 57001 Thessaloniki, Greece
Interests: prostate cancer; renal cancer; ovarian cancer; homologous recombination of DNA; PARP inhibitors; cervical cancer; carcinoma of unknown primary; colorectal cancer; cancer and autoimmune diseases; biomarkers
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Special Issue Information
Dear Colleagues,
Parkinson’s disease (PD) and related neurodegenerative disorders pose a growing global health challenge, affecting millions with progressive motor and cognitive decline. Despite extensive research, the precise molecular mechanisms underlying PD remain elusive, with genetic and environmental interactions playing critical roles. Understanding the pathophysiology of PD—including emerging insights into α-synuclein aggregation, mitochondrial dysfunction, neuroinflammation, and novel genetic risk factors—is of paramount importance.
A pressing concern is the variability in disease progression and treatment response, highlighting the need for personalized therapeutic strategies. While current treatments offer symptom management, breakthroughs in gene therapy, neuroprotective agents, and precision medicine are reshaping the landscape. Additionally, the integration of machine learning and artificial intelligence in predicting disease onset, progression, and treatment outcomes holds transformative potential. We invite original research and comprehensive reviews that uncover novel molecular targets, refine diagnostic biomarkers, and advance AI-driven predictive models to revolutionize PD care and improve patient outcomes.
Guiding this exploration are Professor Stergios Boussios and Dr. David Olawade (University of East London), whose expertise is crucial in this Special Issue.
Prof. Dr. Stergios Boussios
Guest Editor
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Keywords
- Parkinson’s disease
- neurodegenerative disorders
- α-synuclein aggregation
- neuroinflammation
- gene therapy
- biomarkers
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