Molecular Mechanisms of the Aging Process: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 20
Special Issue Editors
Interests: protein homeostasis; mitochondrial dysfunction; inflammation; models for ageing and age-related diseases and treatment strategies
Special Issues, Collections and Topics in MDPI journals
2. Department of Neuroscience, BioMedicum, Karolinska Institutet, Stockholm, Sweden
Interests: mitochondrial dysfunction; metabolism; epigenetics; development; brain plasticity; models for ageing and neurodegenerative diseases and possible treatments
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our Special Issue “Molecular Mechanisms of the Aging Process” (https://www.mdpi.com/journal/ijms/special_issues/SB61B421T6).
Over the past decade, research on the molecular mechanisms of aging has surged, including the discovery of the epigenetic clock as a potential biomarker of aging and pioneering work on using Yamanaka factors to reverse the overall process.
Genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis are the new revised hallmarks of aging. They are implicated not only in the aging process but also in numerous diseases, many of which are age-related, including cancers, metabolic diseases and diabetes, inflammatory conditions, neuropathy, stroke, and neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s disease, as well as amyotrophic lateral sclerosis. The challenge of the aging field is now to disentangle the interconnectedness hallmarks of aging in order to determine their individual contributions to the overall process and enable the development of new therapies that may ameliorate or slow aging in humans. Lifestyle interventions such as calorie restriction and exercise, along with small-molecule therapies, have shown increasing promise potential treatments to improve healthspan and combat age-related diseases.
We invite you to explore recent advancements in the vast field of aging research. This Special Issue welcomes original research articles, mini and full reviews, and perspectives that address the progress and current state of molecular mechanisms underlying the aging process, particularly in the following areas:
- Aging;
- Dementias and neurodegenerative diseases;
- Treatments to counteract the aging process;
- Protein homeostasis and mitochondrial quality control;
- Chronic inflammation and inflammatory diseases;
- Senescence and senolytics;
- Oxidative stress;
- Metabolic disorders and diabetes;
- Reprogramming/regeneration;
- Cancers;
- Epigenetics.
Dr. Giuseppe Coppotelli
Dr. Jaime M. Ross
Guest Editors
Manuscript Submission Information
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Keywords
- aging process
- molecular mechanisms
- epigenetic clock
- cancer
- metabolic disease
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