Understanding Aging in Health and Disease

Dear Colleagues,

Ageing is a gradual and irreversible pathophysiological process influenced by a complex interplay of genetic, environmental, and social factors. It is characterised by a decline in the function of tissues and cells, often accompanied by an increased risk of age-related diseases. Important changes in ageing involve alterations in the immune system and its components, a phenomenon known as immunosenescence. Additionally, senescence cells are characterised by a specific phenotype known as the senescence-associated secretory phenotype (SASP), which results from the secretion of pro-inflammatory mediators. Together, these factors contribute to “inflammaging”—a chronic, low-grade inflammation that has been demonstrated to play a significant role in the progression of ageing and in age-related diseases.

This Special Issue will be focused on the ageing process both in health and disease. We invite contributions that investigate the roles of immunosenescence, inflammaging, and oxidative stress in ageing, as well as how these mechanisms are altered in pathological conditions. In addition, we welcome studies exploring how various lifestyle strategies can influence immune, redox, and inflammatory states in the context of ageing.

Dr. Laura Cianfruglia
Guest Editor

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