ijms-logo

Journal Browser

Journal Browser

Understanding Aging in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 56

Special Issue Editor


E-Mail Website
Guest Editor
Advanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy
Interests: aging; oxidative stress; molecular mechanism; cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ageing is a gradual and irreversible pathophysiological process influenced by a complex interplay of genetic, environmental, and social factors. It is characterised by a decline in the function of tissues and cells, often accompanied by an increased risk of age-related diseases. Important changes in ageing involve alterations in the immune system and its components, a phenomenon known as immunosenescence. Additionally, senescence cells are characterised by a specific phenotype known as the senescence-associated secretory phenotype (SASP), which results from the secretion of pro-inflammatory mediators. Together, these factors contribute to “inflammaging”—a chronic, low-grade inflammation that has been demonstrated to play a significant role in the progression of ageing and in age-related diseases.

This Special Issue will be focused on the ageing process both in health and disease. We invite contributions that investigate the roles of immunosenescence, inflammaging, and oxidative stress in ageing, as well as how these mechanisms are altered in pathological conditions. In addition, we welcome studies exploring how various lifestyle strategies can influence immune, redox, and inflammatory states in the context of ageing.

Dr. Laura Cianfruglia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunosenescence
  • age-related disease
  • ageing
  • oxidative stress
  • inflammaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers

This special issue is now open for submission.
Back to TopTop