Understanding Aging in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 83
Special Issue Editor
Interests: aging; oxidative stress; molecular mechanism; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ageing is a gradual and irreversible pathophysiological process influenced by a complex interplay of genetic, environmental, and social factors. It is characterised by a decline in the function of tissues and cells, often accompanied by an increased risk of age-related diseases. Important changes in ageing involve alterations in the immune system and its components, a phenomenon known as immunosenescence. Additionally, senescence cells are characterised by a specific phenotype known as the senescence-associated secretory phenotype (SASP), which results from the secretion of pro-inflammatory mediators. Together, these factors contribute to “inflammaging”—a chronic, low-grade inflammation that has been demonstrated to play a significant role in the progression of ageing and in age-related diseases.
This Special Issue will be focused on the ageing process both in health and disease. We invite contributions that investigate the roles of immunosenescence, inflammaging, and oxidative stress in ageing, as well as how these mechanisms are altered in pathological conditions. In addition, we welcome studies exploring how various lifestyle strategies can influence immune, redox, and inflammatory states in the context of ageing.
Dr. Laura Cianfruglia
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- immunosenescence
- age-related disease
- ageing
- oxidative stress
- inflammaging
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