Type 2 Diabetes: Molecular Pathophysiology and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 706
Special Issue Editor
Interests: flow cytometry; membrane transporters; type 2 diabetes; gout; rheumatoid arthritis; genotyping; function and regulation of ABC membrane transporter proteins; red blood cells; immunometabolism
Special Issue Information
Dear Colleagues,
Type 2 diabetes mellitus (T2DM) is a prevalent chronic metabolic disorder affecting over 400 million individuals globally, characterized by hyperglycemia resulting from insulin resistance and/or relative insulin deficiency. Representing approximately 90% of all diabetes cases, T2DM is a multifactorial disease, influenced by genetic predisposition, lifestyle factors, hormonal imbalances, infections, and pharmacological agents. This complexity presents significant challenges in the accurate diagnosis and effective management of the disease. Prolonged T2DM increases the risk of serious complications, including cardiovascular disease, stroke, kidney failure, peripheral ischemia, and retinopathy, while the presence of comorbid conditions further exacerbates the burden on patients.
This Special Issue aims to compile cutting-edge original research and review articles exploring the bioinformatics, molecular, genetic, and immunological mechanisms underlying T2DM pathogenesis, as well as their potential as predictive, preventive, and prognostic markers. Additionally, this Special Issue invites research and review articles that present state-of-the-art advancements in therapeutic approaches for T2DM, highlighting innovative treatments and emerging strategies aimed at improving disease management and patient outcomes.
Dr. Edit Szabó
Guest Editor
Manuscript Submission Information
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Keywords
- type 2 diabetes mellitus and comorbidity
- bioinformatics
- molecular pathways
- genetic background
- biomarkers
- novel therapies
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