Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 17
Special Issue Editors
Interests: cigarette smoke; cellular oxidative stress; inflammation; smoking related diseases; antioxidant
Special Issues, Collections and Topics in MDPI journals
Interests: epithelial and mesothelial barriers; fluid, ion and polypeptide transports; MALT; pleural liquid; pleural friction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lung injury is a leading worldwide health concern that is caused by environmental factors such as industrial, household, and environmental xenobiotics; air pollutants; microbiological agents; and cigarette smoke. These factors trigger complex molecular and cellular responses, including oxidative stress, inflammation, immune dysregulation, impaired autophagy, and tissue remodelling, which result in the development and progression of respiratory diseases, such as chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, acute respiratory distress syndrome (ARDS), and lung cancer.
The aim of this Special Issue is to gather the latest research on the molecular mechanisms underlying lung injury, with a particular focus on their clinical and translational implications.
This Special Issue is supervised by Dr. Maria Lisa Garavaglia, Dr. Cristina Porta, and assisted by Dr. Francesca Bodega (Department of Pathophysiology and Transplantation, University of Milan). We welcome the submission of manuscripts covering topics such as the role of environmental pollutants and toxins in lung pathology; the molecular and cellular responses to lung injury, including inflammation and fibrosis; oxidative stress and mitochondrial dysfunction in respiratory diseases; emerging biomarkers for early detection and progression of lung diseases; and novel therapeutic approaches targeting pathways related to lung injury.
By gathering cutting-edge research, this Special Issue may contribute to improving our understanding of lung injury mechanisms and to promoting the development of new strategies for prevention and treatment of lung diseases. To provide a comprehensive view of this topic, contributions from researchers and clinicians across various disciplines are welcomed.
Dr. Maria Lisa Garavaglia
Dr. Cristina Porta
Guest Editors
Manuscript Submission Information
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Keywords
- lung injury
- lung cancer
- pulmonary fibrosis
- chronic obstructive pulmonary disease
- acute respiratory distress syndrome
- environmental pollutants and toxins
- molecular and cellular mechanisms
- biomarkers
- therapeutic approaches
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