PD-L1 – PD1 Signaling Axis: From Mechanism to Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 131
Special Issue Editors
Interests: PD-L1; biomarker; lung cancer; immunotherapy; immune checkpoint blockade
Special Issues, Collections and Topics in MDPI journals
Interests: PD-L1; PD-L1 pathway; immunotherapy; cancer; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The aim of this Special Issue is to explore the intricate molecular mechanisms of PD-L1 and PD-1 in cancer development and progression, as well as the transformative impact of immunotherapy. PD-L1 and PD-1 are critical immune checkpoint molecules that play a pivotal role in immune evasion by cancer cells, enabling tumor growth and metastasis. It seeks to provide a comprehensive understanding of the regulatory pathways, genetic and epigenetic factors, and post-translational modifications that govern the expression and activity of PD-L1 and PD-1 in the tumor microenvironment.
Given the high number of non-responders to anti-PD-1 and anti-PD-L1 therapies, this Special Issue will also explore emerging therapeutic approaches, including combination strategies and novel biomarkers for patient stratification.
By bringing together cutting-edge research and reviews, this Special Issue aims to advance our understanding of the PD-L1/PD-1 axis and its therapeutic potential, fostering innovation in cancer immunotherapy and improving patient outcomes. Researchers, clinicians, and industry experts are invited to contribute their insights to this dynamic and rapidly evolving field.
Dr. Grazyna Kochan
Dr. David Escors
Guest Editors
Manuscript Submission Information
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Keywords
- PD-L1/PD1 immune checkpoints
- cancer
- mechnistic insights and resistances
- adaptive immune regulation
- therapeutic strategies
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