Molecular Insights into Angiogenesis: Mechanisms, Signaling, and Therapeutic Horizons
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 111
Special Issue Editor
Interests: mathematical modeling and inference in biology; physiology and epidemiology; computational and systems biology; angiogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Angiogenesis, the process of forming new blood vessels from pre-existing ones, is critically regulated by various factors, most importantly, vascular endothelial growth factor (VEGF). As such, VEGF was suggested for the treatment of coronary artery disease and peripheral arterial disease. Moreover, due to the role of VEGF in tumor vascularization, it was proposed that targeting VEGF or the cell membrane receptor tyrosine kinases it binds to would result in the inhibition of angiogenesis, ultimately counteracting tumor growth in humans. Furthermore, owing to similar reasoning, anti-VEGF drugs have been used for the treatment of neovascular age-related macular degeneration, and of diabetic retinopathy.
However, despite initial promises, these therapeutic approaches often fail to produce lasting clinical benefits, indicating that our current comprehension of the molecular processes underpinning angiogenesis remains incomplete.
This Special Issue of the International Journal of Molecular Sciences will feature a collection of research articles and reviews exploring the latest advancements in angiogenesis research at the biochemical and molecular levels. We welcome contributions that investigate the molecular signaling pathways governing angiogenesis, intracellular signal transduction dynamics, and novel biomarkers relevant to disease progression and therapeutic targeting. Studies employing innovative in vitro and in vivo models—including organ-on-a-chip systems, single-cell analyses, and advanced imaging techniques—are particularly encouraged. Additionally, submissions addressing the translational impact of angiogenesis research, such as novel drug discovery approaches and personalized medicine strategies, are highly welcome.
By compiling cutting-edge research in this field, this Special Issue aims to bridge the gap between fundamental molecular mechanisms and therapeutic applications, fostering new insights into angiogenesis and its clinical implications.
Dr. Edgar Delgado-Eckert
Guest Editor
Manuscript Submission Information
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Keywords
- angiogenesis
- VEGF
- intracellular signaling in vascular biology
- anti-angiogenic therapy for cancer
- artery disease
- age-related macular degeneration
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