Molecular Perspectives on Natural Antioxidants in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 10
Special Issue Editor
Interests: obesity; brown adipocytes; adipogenesis; thermogenesis; AMP-activated protein kinase; high-fat diet
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress, defined by the dysregulation and overproduction of reactive oxygen species (ROS), is a pivotal pathogenic driver in a spectrum of human diseases, including metabolic disorders, neurodegenerative conditions, cardiovascular disease, and cancer. This persistent redox imbalance inflicts molecular damage upon lipids, proteins, and nucleic acids, disrupting cellular homeostasis. While natural antioxidants such as polyphenols, carotenoids, and vitamins are widely recognized for their health benefits, their mechanisms of action are far more complex than direct ROS scavenging. This Special Issue, "Molecular Perspectives on Natural Antioxidants in Health and Disease," aims to invite cutting-edge research on these complex molecular interactions.
We especially welcome original research and review articles focusing on the following:
- The activation of the Nrf2-ARE signaling pathway and the subsequent transcriptional upregulation of endogenous cytoprotective enzymes.
- The attenuation of pro-inflammatory signaling cascades, such as NF-κB, JAK/STAT, and MAPK pathways.
- The modulation of mitochondrial bioenergetics, quality control, and ROS production.
- Interactions with specific cellular receptors, ion channels, or epigenetic modifications.
Understanding this molecular grammar is critical for translating natural product research into mechanism-based therapeutics for human health and disease.
Dr. Jinbong Park
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural antioxidants
- oxidative stress
- molecular mechanisms
- polyphenols
- NRF2 signaling pathway
- mitochondrial homeostasis
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