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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 31 May 2025 | 1 articles | Viewed by 807 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 31 May 2025 | Viewed by 777 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Advances of Organic Synthesis in Drug Discovery

edited by

Laura Gabriela Sârbu

submission deadline 31 May 2025 | 2 articles | Viewed by 756 | Submission Open

Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization

(This special issue belongs to the Section Molecular Pharmacology)

Precision Medicine Approaches to Antifibrotic Therapy

edited by Karim Daliri

submission deadline 31 May 2025 | 1 articles | Viewed by 697 | Submission Open

Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics in Neurological Diseases

edited by

Julián Benito-León

submission deadline 31 May 2025 | 1 articles | Viewed by 639 | Submission Open

Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 31 May 2025 | 1 articles | Viewed by 547 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition)

edited by

José Justicia

and

Rachid Chahboun

submission deadline 31 May 2025 | 1 articles | Viewed by 523 | Submission Open

Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 31 May 2025 | 1 articles | Viewed by 518 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue

edited by

Ahmed Bettaieb

submission deadline 31 May 2025 | Viewed by 505 | Submission Open

Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Soybean Molecular Breeding

edited by Dong Cao

submission deadline 31 May 2025 | 1 articles | Viewed by 499 | Submission Open

Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Nutritional Regulation on Gut Microbiota

edited by

Yaotsung Yeh

submission deadline 31 May 2025 | Viewed by 497 | Submission Open

Keywords: gut microbiota; dysbiosis; nutritional regulation; foods; diets

(This special issue belongs to the Section Molecular Microbiology)

New Molecular Insights into Ischemia/Reperfusion: 2nd Edition

edited by

Moo-Ho Won

submission deadline 31 May 2025 | 1 articles | Viewed by 469 | Submission Open

Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Regulation of Animal Fat and Muscle Development

edited by Taiyong Yu

submission deadline 31 May 2025 | 1 articles | Viewed by 393 | Submission Open

Keywords: animal fat; muscle development; adipogenesis; PPARγ ; C/EBPs; food additives; metabolic pathways; meat quality; preadipocytes; MyoD

(This special issue belongs to the Section Molecular Biology)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 31 May 2025 | 1 articles | Viewed by 378 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Supramolecular Chiral Self-Assembly and Applications

edited by

Victor Borovkov

Alessandro D'Urso

and

Manuela Stefanelli

submission deadline 31 May 2025 | Viewed by 316 | Submission Open

Keywords: (supra)molecular chirality; chiral self-assembly; enantioselective catalysis

(This special issue belongs to the Section Macromolecules)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 31 May 2025 | Viewed by 283 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Molecularly Targeted Therapy and Regulation of Signaling Pathway in Oral Squamous Cell Carcinoma

edited by

Lucrezia Togni

submission deadline 31 May 2025 | 1 articles | Viewed by 281 | Submission Open

Keywords: head and neck cancers; oral squamous cell carcinoma; targeted therapies; omics sciences; signaling pathway; mutations; prognosis; diagnostic markers

(This special issue belongs to the Section Molecular Oncology)

Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry

edited by

Robert O'Reilly

submission deadline 31 May 2025 | Viewed by 276 | Submission Open

Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nanodiagnosis and Treatment System for Human Health

edited by

Nan Gao

submission deadline 31 May 2025 | 1 articles | Viewed by 272 | Submission Open

Keywords: nanodiagnosis; nanodrugs; nano-antibody; nanosensor; nanoprobe technology

(This special issue belongs to the Section Molecular Nanoscience)

Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance

edited by

Gabriella Doronzo

submission deadline 31 May 2025 | Viewed by 243 | Submission Open

Keywords: Endothelial-to-Mesenchymal Transition; wound healing and fibrosis; tumor progression; abnormal blood vessel formation; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Mechanotransduction and Tissue Regeneration in Skeletal Muscle

edited by

Mahtab Nourbakhsh

submission deadline 31 May 2025 | Viewed by 226 | Submission Open

Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages

(This special issue belongs to the Section Molecular Biology)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 31 May 2025 | Viewed by 220 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 31 May 2025 | Viewed by 192 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 31 May 2025 | Viewed by 189 | Submission Open

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insight into Bacteriophage and Their Potential Applications

edited by Wilfried Moreira

submission deadline 31 May 2025 | Viewed by 188 | Submission Open

Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 May 2025 | Viewed by 187 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Methylation in Cancer: Progress and Challenges

edited by

Michael Eccles

submission deadline 31 May 2025 | Viewed by 186 | Submission Open

Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mechanistic and Data-Driven Modelling Approaches for Regulatory Networks and Diseases

edited by

Tianhai Tian

submission deadline 31 May 2025 | Viewed by 185 | Submission Open

Keywords: mathematical modelling; data-driven approach; mechanistic and data dual-driven approach; hybrid modelling; machine learning; modelling of regulatory network; inference of molecular regulation; cancer; infection disease; disease intervention

(This special issue belongs to the Section Molecular Informatics)

Innovations in Neuropharmacology for Neurodegenerative Diseases

edited by Andrea Fagiolini

submission deadline 31 May 2025 | Viewed by 182 | Submission Open

Keywords: neurodegenerative diseases; neuropharmacology; alzheimer's disease; parkinson's disease; gene therapy; drug delivery systems; molecular mechanisms; biomarkers in neurodegeneration; neuroinflammation; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Regulatory Mechanisms Underlying Tumorigenesis

edited by

Kazuhiko Kuwahara

submission deadline 31 May 2025 | Viewed by 172 | Submission Open

Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models

(This special issue belongs to the Section Molecular Oncology)

Apoptosis and Autophagy in Cancer Research

edited by

Ioana Berindan-Neagoe

and

Radu Pirlog

submission deadline 31 May 2025 | Viewed by 171 | Submission Open

Keywords: apoptosis; autophagy; cancer biology; coding and noncoding genomes; cell homeostasis; therapeutic strategies; cell death and survival

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Non-Conventional and Complementary Treatments for Inflammatory Bowel Disease

edited by Roberta Ottria and

Giovanni Maconi

submission deadline 31 May 2025 | Viewed by 167 | Submission Open

Keywords: inflammatory bowel disease; leaky gut; molecular mechanisms; inflammatory pathways; small molecules in inflammatory bowel disease; non-conventional treatment; complementary medicine; inflammatory cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care

edited by Sandeep Surendra Panikar

submission deadline 31 May 2025 | Viewed by 164 | Submission Open

Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Antiviral Mechanisms of Natural/Synthetic Compounds

edited by Cybele Carina García

submission deadline 31 May 2025 | Viewed by 163 | Submission Open

Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Applications of Programmable Nanobiomaterials in Cancer Targeting and Therapy

edited by Wensheng Xie

submission deadline 31 May 2025 | Viewed by 160 | Submission Open

Keywords: programmable nanobiomaterials; cancer targeting; cancer combined therapy; tumor imaging; field-responsive nanomaterials

(This special issue belongs to the Section Molecular Biophysics)

Metabolic Reprogramming in Health and Aging-Related Diseases

edited by

Hung-Yao Ho

submission deadline 31 May 2025 | Viewed by 157 | Submission Open

Keywords: aging; degenerative diseases; lifestyle intervention; metabolic reprogramming; metabolic syndromes; metabolome; metabolomics; neurodegenerative diseases; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 31 May 2025 | Viewed by 156 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulatory Network of Bone Metabolism

edited by

Kazunori Hamamura

submission deadline 31 May 2025 | Viewed by 155 | Submission Open

Keywords: osteoblasts; osteoclasts; osteocytes; mesenchymal stem cells; bone metabolism; bone formation; bone resorption

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 31 May 2025 | Viewed by 145 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Targets on Anticancer Research and Perspectives

edited by

Apostolos E. Papalois

submission deadline 31 May 2025 | Viewed by 142 | Submission Open

Keywords: anticancer; molecular targets; targeted cancer therapies; malignancy

(This special issue belongs to the Section Molecular Oncology)

Immunopathogenesis and Novel Therapeutic Strategies for Systemic Lupus Erythematosus: Third Edition

edited by

Marzena Olesińska

and Hanna Przepiera-Bȩdzak

submission deadline 31 May 2025 | Viewed by 138 | Submission Open

Keywords: systemic lupus erythematosus; SLE pathogenesis; the epigenetic regulation of lupus; the genetic background of SLE; interferon; cytokine networks; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 31 May 2025 | Viewed by 137 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

Advances in Leptin Biology

edited by

Víctor Sánchez-Margalet

submission deadline 31 May 2025 | Viewed by 135 | Submission Open

Keywords: leptin; leptin expression; leptin receptor; leptin action

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Biological Function of Tyrosinase

edited by

Kazumasa Wakamatsu

submission deadline 31 May 2025 | Viewed by 134 | Submission Open

Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders

(This special issue belongs to the Section Molecular Biology)

Unveiling the Complexity of TRPC Channels: From Molecular Mechanisms to Clinical Applications

edited by Oleksandra Tiapko

submission deadline 31 May 2025 | Viewed by 132 | Submission Open

Keywords: TRPC channels; TRPC– lipid interactions; TRPC– protein interactions; cellular homeostasis; TRPC-dependent disorders; (photo)pharmacology; TRPC in native tissue

(This special issue belongs to the Section Molecular Biology)

Epigenetic and RNA-Based Regulation in Cancer: Mechanism, Therapeutic Targets, and Translational Perspectives

edited by

Moon Nyeo Park

submission deadline 31 May 2025 | Viewed by 129 | Submission Open

Keywords: molecular underpinnings of DNA; histone; RNA-based epigenetic regulation; small molecules and epigenetic inhibitors; epigenetic signatures; oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Signaling and Cellular Mechanisms in Asthma

edited by

Kapil Sirohi

submission deadline 31 May 2025 | Viewed by 128 | Submission Open

Keywords: asthma; endotypes; pausi-immune asthma; nonatopic asthma; steroid insensitivity; neutrophilic asthma; innate lymphoid cells; Th2 cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Immunology of Infectious Diseases

edited by