Molecular Physiopathological Role of Hypoxia

Dear Colleagues,

Hypoxia represents a unique condition with a pivotal role in physiology and pathology. The response to hypoxic conditions occurs at the cellular level through the stabilization of hypoxia-inducible factors (HIFs), which, in turn, causes the activation of downstream molecular pathways. Cell and tissue damage due to acute hypoxia leads to cell necrosis, but in chronic hypoxic conditions, cells can survive by adapting their phenotype. A stably hypoxic microenvironment activates inflammation, resulting in chronic damage, cell death, angiogenesis, fibrosis, and even cancer. Hypoxic stress also affects immunity and is associated with myocardial infarctions and strokes, age-related diseases, diabetes, obesity, neurodegenerative diseases, and storage disorders. Studies in this field have improved our understanding of several aspects of these diseases, but further investigation is still required to determine the molecular mechanisms underlying their onset and progression in order to identify potential targets for intervention. This Special Issue of IJMS, entitled "Molecular Physiopathological Role of Hypoxia", intends to collect and publish papers dealing with all aspects of responses to hypoxia in physiological and pathological conditions and investigating the molecular pathways and responses to oxygen deprivation.

Dr. Michele Aventaggiato
Guest Editor

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