Single Cell Transcriptomics in Human Disease

Dear Colleagues,

Brain aging is a complex biological process characterized by progressive molecular and cellular alterations that contribute to cognitive decline and increased vulnerability to neurodegenerative diseases. Single-cell transcriptomics has emerged as a revolutionary technology enabling unprecedented resolution in understanding the heterogeneous nature of brain aging at the cellular level. This Special Issue aims to explore the latest advances in single-cell RNA sequencing (scRNA-seq) and related technologies applied to investigate age-related changes in the brain. We welcome original research articles and reviews addressing cell type-specific transcriptional changes during aging, the identification of novel aging biomarkers, comparative analyses across brain regions, and the molecular mechanisms underlying cellular senescence in neural tissues. Topics of interest include but are not limited to age-related alterations in neuronal and glial cell populations, changes in cell–cell communication during aging, spatial transcriptomics approaches to brain aging, integration of multi-omics data, and potential therapeutic targets emerging from single-cell studies. This Special Issue will provide a comprehensive platform for researchers to share cutting-edge findings that will advance our understanding of brain aging and pave the way for novel interventions to promote healthy cognitive aging.

Dr. Md. Mahmudul Hasan
Guest Editor

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