Emerging Insights into Endothelial Biology and Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 160
Special Issue Editor
Interests: endothelial inflammation; endothelial permeability; vascular remodeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endothelial cells, which line the vascular system, are central to nearly all major life-threatening and chronic diseases. They regulate leukocyte trafficking, immune surveillance, and inflammatory responses through adhesion molecules and chemokine signaling. Beyond these immune functions, endothelial cells influence vascular integrity, angiogenesis, and organ-specific communication, making them critical targets for therapeutic intervention in cardiovascular and inflammatory disorders.
Although generally quiescent, endothelial cells remain metabolically active. Recent advances reveal that endothelial metabolic pathways, including glycolysis, fatty acid oxidation, and amino acid signaling, govern vascular permeability, microvascular and macrovascular remodeling, and shear stress adaptation. Furthermore, emerging evidence links mitochondrial dysfunction and altered dynamics in endothelial cells to cardiovascular risk factors, highlighting new opportunities for intervention.
This Special Issue invites original research and reviews that advance our understanding of endothelial biology and metabolism, with a particular focus on the following:
- Mechanisms of endothelial activation and dysfunction;
- Regulation of angiogenesis, migration, and barrier function;
- Mitochondrial function and metabolism in vascular health;
- Oxidative phosphorylation (OxPhos) in endothelial cells;
- Innovative therapeutic strategies, including mitochondria-targeted compounds;
- Endothelial responses to shear stress and vascular remodeling.
We welcome contributions that explore molecular pathways, translational approaches, and in vivo models aimed at preserving endothelial health and treating vascular-related diseases.
Dr. Hemant Giri
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- endothelial dysfunction
- endothelial activation
- vascular biology
- endothelial migration
- angiogenesis
- vascular permeability
- shear stress
- microvascular and macrovascular remodeling
- leukocyte trafficking
- mitochondrial function
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