Host–Microbiome Crosstalk: Mitochondria, Extracellular Vesicles, and Redox Regulation in Aging

Dear Colleagues,

Aging is shaped by complex molecular interactions between host cells and the gut microbiome, involving mitochondrial function, redox homeostasis, and intercellular communication. Increasing evidence highlights the role of microbiota-derived metabolites and extracellular vesicles as key modulators of host signaling pathways that influence oxidative stress, inflammation, cellular senescence, and tissue homeostasis.

This Special Issue focuses on the molecular basis of host–microbiome crosstalk in aging, with particular emphasis on mitochondria, extracellular vesicles, and redox-regulated signaling mechanisms. We welcome original research articles and reviews addressing mechanistic insights into microbial and host-derived extracellular vesicles, mitochondrial dynamics and bioenergetics, redox signaling pathways, immune-metabolic interactions, and aging-associated dysfunction. Studies integrating experimental models, multi-omics approaches, and translational perspectives are encouraged.

By bringing together interdisciplinary contributions, this Special Issue aims to advance understanding of how host-microbiome interactions regulate molecular aging processes and to identify potential therapeutic targets for promoting healthy aging.

Dr. Efthalia Moustakli
Guest Editor

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