Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

Dear Colleagues,

Pharmacogenetics is transforming medicine by enabling personalized drug therapy. As technology advances and barriers are addressed, its integration into routine clinical practice will improve patient outcomes, reduce adverse drug reactions, and optimize healthcare delivery. Genetic variation in pharmacogenes, such as drug-metabolizing enzymes and transporters, is common and may increase the risk of adverse drug reactions or reduce treatment effectiveness. Many of these variations often differ between panels, and many pharmacogenetic associations lack robust clinical validation, especially in diverse populations, leading to disparities in personalized medicine. This Special Issue will cover such variations and a wide range of topics related to the pharmacogenetic associations from bench to bedside.

Topics of interest include, but are not limited to, the following:

• Artificial intelligence and machine learning approaches in pharmacogenetics;
• Multi-omics approaches for understanding of drug response;
• Pharmacogenetics in personalized drug therapy;
• Pharmacogenetic variation in response to drugs;
• Bioinformatics approaches in pharmacogenetics;
• Epigenetic signatures;
• Biomarkers targeting human diseases;
• Microbiome metagenomic approaches;
• Approaches to embed pharmacogenetics into clinical practice;
• Pharmacogenetics approaches to improve patient outcomes;
• Drug–gene interactions;
• Drug–drug–gene interactions;

We welcome the submission of original articles, reviews, and communications by experts in this field. This Special Issue is supervised by Guest Editors Dr. Kumaraswamy Naidu Chitrala and Dr. Suneetha Yeguvapalli.

Dr. Kumaraswamy Naidu Chitrala
Guest Editor

Manuscript Submission Information

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