Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders

Dear Colleagues,

Cardiometabolic disorders, including type 2 diabetes, obesity, metabolic syndrome, hypertension, and cardiovascular disease, are among the leading causes of morbidity and mortality worldwide. Population aging and lifestyle-related factors significantly increase the prevalence of these conditions and the risk of severe complications such as myocardial infarction and stroke. Despite advances in pharmacological treatments, cardiometabolic risks increase; therefore, effective adjunct therapeutic strategies are needed, especially based on the compounds that have low toxicity and could be safely used for prolonged time periods.

Oxidative stress, chronic inflammation, endothelial dysfunction, insulin resistance, and mitochondrial impairment are key mechanisms driving cardiometabolic disease development and progression. Increasing evidence suggests that natural bioactive molecules may beneficially modulate these interconnected pathways. Phenolic compounds have attracted growing attention due to their action as redox and signaling modulators, improving metabolic homeostasis and vascular function. Furthermore, phenolic compounds are transformed by gut microbes and actively shape microbial composition and function, opening new possibilities for gut microbiota regulation.

Consequently, phenolic compounds that target oxidative stress, inflammation, and metabolic dysregulation may represent promising adjunct therapies for cardiometabolic disorders. We invite you to submit original research articles or review papers to this Special Issue, “Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders,” which focuses on natural phenolic compounds, their mechanisms of action, bioavailability, and clinical relevance in cardiometabolic disease management. Please note that as the Issue focuses on molecular research, pure clinical research papers will not be accepted.

Dr. Dalia Marija Kopustinskiene
Guest Editor

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