Vitamin D Metabolism and Molecular Signaling in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 24
Special Issue Editor
Interests: proteins; opioids; nutrigenomics; polymorphism; SNPs; mutations; vitamins; markers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Vitamin D is a pleiotropic secosteroid hormone that plays an important role in human physiology far beyond calcium and bone homeostasis. Accumulating evidence highlights its involvement in the regulation of immune responses, cell proliferation and differentiation, metabolic homeostasis, and inflammation through tightly controlled molecular signaling pathways. Dysregulation of vitamin D metabolism has been implicated in the pathogenesis of numerous human diseases, including autoimmune disorders, metabolic syndrome, cardiovascular diseases, cancer, and neurodegenerative conditions.
This Special Issue aims to provide a comprehensive overview of current advances in the molecular biology of vitamin D, focusing on its metabolic pathways, genomic and non-genomic signaling mechanisms, and their relevance to human disease development and progression. We welcome original research articles and high-quality reviews addressing molecular, cellular, genetic, and epigenetic aspects of vitamin D action, as well as translational studies exploring novel biomarkers, therapeutic targets, and personalized approaches based on vitamin D status and signaling.
Research areas may include, but are not limited to:
- Molecular mechanisms of vitamin D metabolism and signaling;
- Vitamin D metabolic pathway components structure, regulation, and gene networks;
- Genomic and non-genomic actions of vitamin D;
- Epigenetic regulation and microRNA interactions in vitamin D signaling;
- Vitamin D and immune system modulation;
- Vitamin D in metabolic, autoimmune, inflammatory, and cardiovascular diseases;
- Vitamin D signaling in cancer biology and tumor microenvironment;
- Gut microbiota–vitamin D interactions;
- Genetic polymorphisms affecting vitamin D metabolism and disease susceptibility;
- Biomarkers and molecular targets related to vitamin D deficiency;
- Translational and precision-medicine approaches involving vitamin D
Prof. Dr. Anna Cieslinska
Guest Editor
Manuscript Submission Information
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Keywords
- vitamin D
- vitamin D metabolism
- molecular signaling
- genomic and non-genomic pathways
- epigenetics
- immune regulation
- inflammation
- metabolic disorders
- autoimmune diseases
- cancer biology
- gut microbiota
- genetic polymorphisms
- precision medicine
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