New Advances in Omega-3 Polyunsaturated Fatty Acids: From Molecular Signaling to Therapeutic Applications

Dear Colleagues,

In recent decades, the field of nutritional biochemistry has undergone a paradigm shift, redefining long-chain N-3 polyunsaturated fatty acids (N-3 PUFAs)—particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—from simple structural nutrients to potent bioactive signaling molecules that can determine cell fate. While epidemiological studies have long supported the association between N-3 PUFA-rich diets and a reduced risk of chronic diseases, translating these findings into consistent clinical therapeutic strategies remains a complex challenge. In the current era of precision nutrition, it is essential to move beyond observational studies to elucidate the specific molecular mechanisms driving these pleiotropic functions.

This Special Issue, entitled “New Advances in Omega-3 Polyunsaturated Fatty Acids: From Molecular Signaling to Therapeutic Applications”, aims to bridge the gap between molecular signaling and therapeutic application. We invite submissions that focus on deep cellular mechanisms beyond general anti-inflammatory effects. Simultaneously, we seek translational research bridging basic science with clinical practice. We encourage studies that examine N-3 PUFAs as adjuvants in stem cell research, cancer research, including chemotherapy or immunotherapy, their protective effects on the blood–brain barrier and neuroplasticity in neurological disorders, their impact on atherosclerotic plaque stability, and the remodeling of the gut microbiota via the gut–brain axis. By gathering high-quality original research and systematic reviews, this Special Issue aims to establish an interdisciplinary platform that connects molecular biologists and clinicians, ultimately advancing precise and personalized nutritional intervention strategies and preventive medicine.

Prof. Dr. Feng-Yao Tang
Guest Editor

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