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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage

edited by Antonio Arnaiz-Villena

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2922 | Submission Open

Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G, E, F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal MHC; Veterinary

(This special issue belongs to the Section Molecular Immunology)

Plant Breeding: Improvements and Applications of High-Yield, High-Quality and Stress-Resistant Genetic Traits

edited by Juwu Gong

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2662 | Submission Open

Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias

edited by Yingjie Liu

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2661 | Submission Open

Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies

(This special issue belongs to the Section Molecular Biology)

Updates on Synthetic and Natural Antioxidants (2nd Edition)

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2635 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Advances in Antimicrobial Agents and Resistance Mechanisms

edited by

Julieta Luna-Herrera

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2581 | Submission Open

Keywords: acquired resistance; antibiotic inactivation; antibiotic modifications; antibiotic uptake; antibiotics; antimicrobial agents; bacterial dormancy; efflux pumps; extrachromosomal elements; genomic mutations; novel antimicrobial molecules; resistant mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2579 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Canonical and Noncanonical Inflammasomes in Inflammation and Diseases

edited by

Young-Su Yi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2557 | Submission Open

Keywords: canonical; noncanonical; inflammasome; inflammation; human diseases; anti-inflammatory therapeutics

(This special issue belongs to the Section Molecular Immunology)

Bioactive Compounds in the Prevention of Chronic Diseases: 2nd Edition

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2551 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy

edited by

Maria Teresa Sciarrone Alibrandi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2494 | Submission Open

Keywords: autosomal dominant polycystic kidney disease; ADPKD progression; cystic kidney disease; cardiovascular complications in ADPKD; biomarkers of ADPKD; genetics of polycystic kidney disease; renal imaging; targeted therapies in ADPKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

ROS and Abiotic Stress in Plants, 3rd Edition

edited by

Tsanko S. Gechev

and

Veselin Petrov

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2488 | Submission Open

Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2445 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into the Structure and Function of Nuclear Receptors

edited by

Elza Fonseca

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2373 | Submission Open

Keywords: transcription factors; endocrine disorders; ligands; xenobiotics; pharmacology; modelling; drug design; evolution; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Lectins: Structural Diversity, Molecular Recognition and Emerging Applications

edited by

Patrícia Maria Guedes Paiva

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2079 | Submission Open

Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications

(This special issue belongs to the Section Biochemistry)

Molecular Advances in the Pathophysiology and Therapy of Cerebral Gliomas

edited by

Placido Bruzzaniti

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2075 | Submission Open

Keywords: mutant IDH1 3; EVs; Ki67; HSV1-TK; glioma; lipid vesicles; viral vectors; ATRX; EGFR; IDH1; MGMT; 1p/19q codeletion

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sellar Region Tumors: New Insights in Their Pathogenesis, Diagnosis and Treatment

edited by

Dimitrios Kanakis

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2064 | Submission Open

Keywords: sellar region tumors; pituitary neuroendocrine tumors (PitNETs); neurohypophyseal tumors; hypothalamic neoplasms; craniopharyngiomas; germ cell tumors; meningiomas; Rathke cleft cysts; chordomas

(This special issue belongs to the Section Molecular Oncology)

Coronavirus Disease (COVID-19): Pathophysiology (7th Edition)

edited by

Malgorzata Kloc

and Jacek Kubiak

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2056 | Submission Open

Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms in Cardiovascular Disease Progression

edited by Ying-Hsi Lin

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1968 | Submission Open

Keywords: cardiovascular disease progression; molecular mechanisms; inflammation; signal transduction; transcriptional and epigenetic regulation; mitochondrial dysfunction; sarcomeric remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies

edited by

Stefan Simović

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1924 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; oxidative stress; molecular mechanisms; translational research; antiarrhythmic therapy; cardiac remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation

edited by Rosanna Avola

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1895 | Submission Open

Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application and Molecular Mechanisms of Microwaves for Materials Processing

edited by

Valentin Craciun

and

Marian Mogildea

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1893 | Submission Open

Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis

edited by

Weibin Shi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1836 | Submission Open

Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives in Tissue Engineering and Regenerative Medicine

edited by

Sorina Dinescu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1795 | Submission Open

Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell–scaffold interactions; nanomaterials

(This special issue belongs to the Section Molecular Biology)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1742 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential

edited by

Alessandro Castorina

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1726 | Submission Open

Keywords: neuropeptides; brain function; neuroinflammation; regeneration; neurodegeneration; biomarkers; therapy; CNS; brain disorders; demyelination

(This special issue belongs to the Section Molecular Neurobiology)

Oral Diseases and Oral Soft Tissue Repair

edited by Diana Russo

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1674 | Submission Open

Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Ocular Inflammation and Infection

edited by

Christine Fardeau

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1658 | Submission Open

Keywords: ocular infections; uveitis; choroiditis; masquerade syndrome; pseudo-uveitis; intraocular lymphoma; retinal dystrophy; ocular inflammation; neuroinflammation; immunotherapy-induced uveitis; autoimmune eye diseases; sarcoidosis; OCT; indocyanine green angiography

(This special issue belongs to the Section Molecular Immunology)

The Signals and Metabolic Mechanisms of Plant-Environment Interactions

edited by Harlene Hatterman-Valenti and

Özkan Kaya

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1608 | Submission Open

Keywords: plant stress signaling; abiotic stress; biotic stress; phytohormones; secondary metabolism; signal transduction; ROS; epigenetic regulation; stress adaptation; plant–environment interaction

(This special issue belongs to the Section Molecular Plant Sciences)

Repair Mechanisms of Stem Cells

edited by

Ana Flores

and

Jose Joaquin Merino

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1489 | Submission Open

Keywords: stem cell biology; stem cells; stem cell therapy; tissue regeneration

(This special issue belongs to the Section Biochemistry)

New Insights into Neuroproteins

edited by

Fabrizio Michetti

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1391 | Submission Open

Keywords: neuroproteins; S100B; glial fibrillary acidic protein; neuron-specific enolase; alpha-synuclein; amyloid proteins

(This special issue belongs to the Section Molecular Neurobiology)

New Perspectives of Colloids for Biological Applications, 2nd Edition

edited by

Agnieszka Ewa Wia̧cek

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1261 | Submission Open

Keywords: colloids; emulsions; dispersions, stability; size distribution; zeta potential; optical/rheological properties; medicine; pharmaceuticals; cosmetics

(This special issue belongs to the Section Materials Science)

Natural Products: Pharmacological Insights and Advances

edited by

Jialuo Huang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1256 | Submission Open

Keywords: natural products; biological activity; pharmacology; mechanism of action; molecular targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Roles of Phytochemicals in Cancer Chemoprevention and Treatment

edited by

Jaemoo Chun

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1250 | Submission Open

Keywords: natural products; phytochemicals; cancer; chemoprevention; cancer therapy; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Spermatogenesis and Male Infertility, 2nd Edition

edited by Wanxi Yang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1194 | Submission Open

Keywords: male reproduction; hormone regulation; blood–testis barrier; male reproductive diseases; male infertility

(This special issue belongs to the Section Molecular Biology)

Breast Cancer and Molecular-Based Treatments

edited by

Marcus Vetter

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1142 | Submission Open

Keywords: breast cancer; immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside

edited by Antonio Arnaiz-Villena

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1079 | Submission Open

Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV

(This special issue belongs to the Section Molecular Immunology)

Multi-Omics Platforms for Comprehensive Biological Insights

edited by

Nagib Ahsan

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1075 | Submission Open

Keywords: allergen; animal; cancer biology; diseases; microbiology; plant; proteomics; post-translational modification; stress biology

(This special issue belongs to the Section Biochemistry)

The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives

edited by

Katarzyna E. Stȩpnik

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1054 | Submission Open

Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Host–Microorganism Interaction

edited by

Mehmet Demirci

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1039 | Submission Open

Keywords: host–microbe interaction; gut microbiota; molecular pathogenesis; metagenomics; immune modulation; microbial dysbiosis; gene expression; antimicrobial resistance; metabolic diseases; biofilm formation

(This special issue belongs to the Section Molecular Microbiology)

Advances in Neuroregenerative Medicine: Molecular Mechanisms, Neuroinflammation, and Translational Approaches

edited by

Rogério Martins Amorim

and

Lucas Vinícius De Oliveira Ferreira

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1027 | Submission Open

Keywords: neuroregeneration; neuroinflammation; regenerative medicine; mesenchymal stem cells; neural stem cells; Schwann cells; translational medicine; extracellular vesicles; peripheral nerve regeneration; 3D bioprinting

(This special issue belongs to the Section Molecular Neurobiology)

Biological Activities and Applications of Marine Algae

edited by

Fatima Lakhdar

and

Bouchra Benhniya

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1001 | Submission Open

Keywords: marine algae; biological activity; bioactive compounds; antimicrobial; antioxidant; anticancer; sustainable natural resources; agriculture; health care; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Telomere Dynamics in Aging and Disease: Biology, Regulation, and Pathogenesis

edited by Jidong Shan

submission deadline 31 Dec 2026 | 1 articles | Viewed by 993 | Submission Open

Keywords: telomeres; telomere length; telomerase; aging; diseases; disorders; cancer

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Evaluations of Anticancer Activity of Multi-Target Inhibitors

edited by

Malgorzata Jelen

and

Małgorzata Dołowy

submission deadline 31 Dec 2026 | 1 articles | Viewed by 988 | Submission Open

Keywords: synthesis of anticancer compounds; multi-target inhibitors; kinase inhibitors; apoptosis modulation; cancer signaling pathways; structure–activity relationships; molecular docking; hybrid molecules

(This special issue belongs to the Section Molecular Pharmacology)

Next-Generation Natural Products in Drug Discovery: From Ethnopharmacology to Precision Medicine

edited by Idris Adewale Ahmed

submission deadline 31 Dec 2026 | 1 articles | Viewed by 937 | Submission Open

Keywords: phytochemicals; pharmacodynamics; pharmacokinetics; formulation strategies; commercialization; nanotechnology; delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Addressing Autoimmunity in the 21st Century

edited by

Yun Liang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 920 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immune-mediated disorders; molecular mechanisms; molecular biomarkers; therapeutic strategies; immunomodulation; immune tolerance

(This special issue belongs to the Section Molecular Immunology)

Cutting Edge Advances in Wound Healing

edited by Fui Ping Lim

submission deadline 31 Dec 2026 | 1 articles | Viewed by 876 | Submission Open

Keywords: wound repair; molecular pathways; regenerative biology; tissue remodelling; inflammation modulation

(This special issue belongs to the Section Molecular Biology)

Exploring Molecular Mechanisms Involved in Head and Neck Cancer

edited by Jae Won Chang

submission deadline 31 Dec 2026 | 1 articles | Viewed by 868 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Activity and Efficacy Evaluation of Natural Products

edited by Fazrena Nadia Md Akhir

submission deadline 31 Dec 2026 | 3 articles | Viewed by 861 | Submission Open

Keywords: natural products; bioactivity; pharmacological efficacy; medicinal plants; marine bioresources; anticancer; anti-inflammatory; synergistic effects; AI-guided discovery; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application of Polysaccharides and Their Derivatives in Drug Delivery

edited by

Pakorn Kraisit

submission deadline 31 Dec 2026 | 1 articles | Viewed by 858 | Submission Open

Keywords: polysaccharides; drug delivery; biomaterials; nanoparticles; controlled release; targeted delivery; hydrogels; biopolymers; drug carriers; biomedical applications

(This special issue belongs to the Section Macromolecules)

Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders

edited by

Amal Kaddoumi

submission deadline 31 Dec 2026 | Viewed by 844 | Submission Open

Keywords: blood–brain barrier; neurodegenerative diseases; Alzheimer’s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow

(This special issue belongs to the Section Molecular Neurobiology)

Latest Research on Drug-Diagnostic Co-Development in Oncology

edited by

Laxmi Swetha Karanam

submission deadline 31 Dec 2026 | Viewed by 830 | Submission Open

Keywords: companion diagnostics; tumor; drug–diagnostic co-development; molecular profiling; biomarker; theranostics

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 1851-1900 on page 38 of 62.

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