Advances in Neuroregenerative Medicine: Molecular Mechanisms, Neuroinflammation, and Translational Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 443
Special Issue Editors
Interests: neuroregeneration; regenerative medicine
2. Center for Translational Research in Regenerative Medicine, Institute of Biotechnology, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil
Interests: cell-based therapies; mesenchymal stem cells; peripheral nerve regeneration; transdifferentiation; schwann cells; veterinary medicine
Special Issue Information
Dear Colleagues,
Neurological injuries and neurodegenerative disorders affecting the central and peripheral nervous systems remain major clinical challenges worldwide. These conditions frequently result in permanent functional impairment due to the limited regenerative capacity of neural tissues. Over the last decade, advances in molecular biology, regenerative medicine, and bioengineering have significantly expanded the field of neuroregenerative medicine, offering new perspectives for the development of innovative therapeutic strategies.
A growing body of evidence demonstrates that neuroinflammation plays a critical role in both neural degeneration and regeneration. Cellular and molecular interactions involving microglia, astrocytes, immune mediators, and inflammatory signaling pathways can strongly influence neuronal survival, axonal growth, synaptic plasticity, and functional recovery. Elucidating the molecular mechanisms underlying neuroinflammatory responses and their relationship with neural repair is therefore essential in the development of targeted regenerative therapies.
In parallel, translational medicine approaches are increasingly recognized as fundamental in bridging basic research and clinical applications. Naturally occurring neurological diseases in animals represent valuable translational models that can accelerate the development of regenerative strategies. Veterinary medicine provides unique opportunities to study neural repair mechanisms in clinically relevant conditions, contributing to the advancement of therapies that may benefit both human and animal patients within a comparative and translational framework.
This Special Issue will showcase high-quality research and review articles that explore molecular mechanisms, emerging regenerative strategies, and translational approaches in neuroregenerative medicine, with a particular emphasis on the interplay between neuroregeneration, neuroinflammation, and innovative therapeutic technologies.
For this Special Issue, we invite contributions addressing molecular, cellular, and translational aspects of neural repair and regeneration. Interdisciplinary studies integrating neuroscience, regenerative medicine, molecular biology, bioengineering, and veterinary medicine are particularly encouraged.
Topics of interest include, but are not limited to, the following:
- Molecular mechanisms underlying neuroregeneration;
- Neuroinflammatory pathways in neurological disorders;
- Stem cell-based therapies for neural repair;
- Mesenchymal stem cells and neural differentiation;
- Schwann cells and Schwann-like cell biology;
- Extracellular vesicles and exosome-mediated neural repair;
- Biomaterials and nerve guidance conduits for neural regeneration;
- Peripheral nerve injury and repair mechanisms;
- Translational animal models of neurological diseases;
- Comparative and translational neuroscience involving veterinary medicine.
I look forward to receiving your contributions.
Dr. Rogério Martins Amorim
Guest Editor
Dr. Lucas Vinícius De Oliveira Ferreira
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Publisher’s Notice
The Special Issue has been shifted from Section Molecular Nanoscience to Section Molecular Neurobiology on 22 April 2026. At the time of the move, there were no publications in this Special Issue.
Keywords
- neuroregeneration
- neuroinflammation
- regenerative medicine
- mesenchymal stem cells
- neural stem cells
- Schwann cells
- translational medicine
- extracellular vesicles
- peripheral nerve regeneration
- 3D bioprinting
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