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New Insights into Neuroproteins

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 March 2026) | Viewed by 884

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Special Issue Information

Dear Colleagues,

Owing to their complex structure, proteins are natural candidates for fulfilling key roles in cells and organs. In particular, although attempts to identify proteins specific to the nervous system and responsible for neural functions have often been useful, these neuroproteins have nevertheless been shown to play especially relevant roles within this system.

Proteins such as S100B, glial fibrillary acidic protein, and neuron-specific enolase have been shown to be useful cell markers. In addition, their levels in biological fluids are currently used to monitor neural disorders. Other molecules, such as alpha-synuclein and amyloid proteins, are regarded as hallmarks of several neurodegenerative disorders. Damage- and danger-associated molecular pattern proteins, along with inflammasome complexes, are also known to play key roles in neuroinflammatory processes, which is particularly important in this system given their pathological implications. In this respect, the specific receptors for these molecules are likewise proteins, such as the Receptor for advanced glycation end product and toll-like receptors in general.

This Special Issue will highlight novel findings in the form of original research articles and reviews dealing with different aspects of neuroprotein biology (in general and with reference to specific neuroproteins), including mechanistic insights and neuroproteins’ role in cells at the molecular level (e.g., gene expression and epigenetic studies, post-translational modifications, regulation of cell processes). Articles dealing with alterations in neuroproteins’ structure and function in human diseases, including their putative role(s) as pathological biomarkers and/or therapeutic targets, are especially welcome.

Prof. Dr. Fabrizio Michetti
Guest Editor

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Keywords

  • neuroproteins
  • S100B
  • glial fibrillary acidic protein
  • neuron-specific enolase
  • alpha-synuclein
  • amyloid proteins

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Published Papers (1 paper)

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Research

25 pages, 4003 KB  
Article
Candidate Key Proteins in Thalamo-Amygdala Signaling in Tinnitus: A Bioinformatics Study
by Johann Gross, Marlies Knipper and Birgit Mazurek
Int. J. Mol. Sci. 2026, 27(4), 1854; https://doi.org/10.3390/ijms27041854 - 14 Feb 2026
Viewed by 582
Abstract
With the aim of identifying key proteins that play a role in the disorder tinnitus, interactions between proteins involved in thalamo-amygdala signaling under conditions of normal hearing (NH), acoustic stimulation (AS), and tinnitus (Tin) were studied. Three gene lists compiled from the GeneCards [...] Read more.
With the aim of identifying key proteins that play a role in the disorder tinnitus, interactions between proteins involved in thalamo-amygdala signaling under conditions of normal hearing (NH), acoustic stimulation (AS), and tinnitus (Tin) were studied. Three gene lists compiled from the GeneCards database using keywords were characterized by analyses of overlap, protein–protein interaction (PPI) networks, and by protein-enrichment analysis. Key proteins were selected on the basis of the degree and combined score value of the corresponding PPI network. In the NH process, BDNF, CASP3, and PVALB were identified as high-degree proteins (HDPs). In the AS process, BDNF, PVALB, and DLG4 are the top three HDPs; in the Tin process, these are BDNF, APP, and TNF. In the Tin process, key proteins appear that differ pre- and postsynaptically from those detectable in NH or AS. The glucocorticoid receptor NR3C1 and its interaction with FKBP5, a glucocorticoid receptor-induced co-chaperone, appear to be of particular importance for the emotional aspects of tinnitus. In tinnitus, the HDPs, together with their high-score interaction proteins, indicate processes of chronic neurodegeneration and of changes in transcription, intercellular communication, and in the survival and growth of neurons. Full article
(This article belongs to the Special Issue New Insights into Neuroproteins)
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