New Insights into Neuroproteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2026
Special Issue Editor
Interests: neurodegeneration; neuroinflammation; multiple sclerosis; amyotrophic lateral sclerosis; animal models of neural diseases; neural biomarkers; calcium-binding neuroproteins; S100B protein
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Owing to their complex structure, proteins are natural candidates for fulfilling key roles in cells and organs. In particular, although attempts to identify proteins specific to the nervous system and responsible for neural functions have often been useful, these neuroproteins have nevertheless been shown to play especially relevant roles within this system.
Proteins such as S100B, glial fibrillary acidic protein, and neuron-specific enolase have been shown to be useful cell markers. In addition, their levels in biological fluids are currently used to monitor neural disorders. Other molecules, such as alpha-synuclein and amyloid proteins, are regarded as hallmarks of several neurodegenerative disorders. Damage- and danger-associated molecular pattern proteins, along with inflammasome complexes, are also known to play key roles in neuroinflammatory processes, which is particularly important in this system given their pathological implications. In this respect, the specific receptors for these molecules are likewise proteins, such as the Receptor for advanced glycation end product and toll-like receptors in general.
This Special Issue will highlight novel findings in the form of original research articles and reviews dealing with different aspects of neuroprotein biology (in general and with reference to specific neuroproteins), including mechanistic insights and neuroproteins’ role in cells at the molecular level (e.g., gene expression and epigenetic studies, post-translational modifications, regulation of cell processes). Articles dealing with alterations in neuroproteins’ structure and function in human diseases, including their putative role(s) as pathological biomarkers and/or therapeutic targets, are especially welcome.
Prof. Dr. Fabrizio Michetti
Guest Editor
Manuscript Submission Information
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Keywords
- neuroproteins
- S100B
- glial fibrillary acidic protein
- neuron-specific enolase
- alpha-synuclein
- amyloid proteins
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