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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Engineering for Advanced Energy Materials and Catalytic Systems
edited by
submission deadline 30 Sep 2026 | Viewed by 175 | Submission Open
Keywords: molecular engineering; energy materials; catalytic systems; batteries; supercapacitors; energy conversion; self-assembled monolayers; CO2 utilization
(This special issue belongs to the Section Materials Science)
Adsorption Materials Design and Mechanism of Molecular Interface Interaction
edited by
submission deadline 30 Sep 2026 | Viewed by 175 | Submission Open
Keywords: adsorption; adsorption materials; adsorption behavior; adsorption mechanism; interface interaction
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Cellular and Molecular Mechanisms in Autoimmune Diseases submission deadline 30 Sep 2026 | Viewed by 168 | Submission Open
Keywords: autoimmune disease; immunological tolerance; T-cell/B-cell dysregulation; innate immunity; cytokine signaling; autoantibody
(This special issue belongs to the Section Molecular Immunology)
Physical Activity and Nutraceuticals as Synergistic Mechanisms for Healthy Aging
edited by
submission deadline 30 Sep 2026 | Viewed by 163 | Submission Open
Keywords: healthy aging; nutraceuticals; cellular senescence; mitochondrial function; oxidative stress; redox balance; autophagy; homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Pathology Techniques to Define Target Safety Risks for Novel Therapeutic Modalities
edited by Rebecca Kohnken
submission deadline 30 Sep 2026 | Viewed by 161 | Submission Open
Keywords: molecular pathology; immunohistochemistry; multiplexing; immunofluorescence; high-content imaging; confocal; biologics; therapeutics; target expression; drug safety
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pancreatic Neuroendocrine Tumors: Current Evidence and Future Horizons
edited by Roberto Cammarata
submission deadline 30 Sep 2026 | Viewed by 140 | Submission Open
Keywords: pancreatic neuroendocrine tumors; surgical oncology; PRRT; somatostatin analogues; liver metastases; molecular targeted therapy; biomarkers; WHO grading; functional tumors; minimally invasive surgery
(This special issue belongs to the Section Molecular Oncology)
Molecular Design of Electrospun Fibers with Natural Bioactives for Biomedical Application
edited by
submission deadline 30 Sep 2026 | Viewed by 136 | Submission Open
Keywords: electrospun fibers; molecular design; natural bioactives; core-shell nanofibers; functional biomaterials; controlled drug release; wound healing; tissue scaffolds; stimuli-responsive systems; antimicrobial polymers
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Therapy of Heart Failure
edited by
submission deadline 10 Oct 2026 | 2 articles | Viewed by 1266 | Submission Open
Keywords: heart failure; organ-cross talk; metabolic derangements; molecular mechansims; sex differences
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Study on Biofunctional Properties of Plant Bioactives submission deadline 10 Oct 2026 | 1 articles | Viewed by 1108 | Submission Open
Keywords: plant bioactives; bioactive compounds; phytochemicals; molecular mechanisms; oxidative stress; anti-inflammatory activity; therapeutic potential; structure–activity relationship; cell culture models; animal models
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Sustainable Bioactives from Plants: From Molecular Function to Fermentation
edited by Zofia Nizioł–Łukaszewska and
submission deadline 10 Oct 2026 | 2 articles | Viewed by 959 | Submission Open
Keywords: agro-industrial by-products; plant-based waste materials; microbial fermentation; biotransformation; molecular characterization; phytochemical profiling; anti-aging activity; dermatological applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Multi-Omics Insights into Cardiovascular and Cerebrovascular Diseases
edited by Alicia Aliena-Valero and María Castelló-Ruiz
submission deadline 10 Oct 2026 | Viewed by 256 | Submission Open
Keywords: multi-omics integration; atherosclerosis; stroke; cerebral small vessel disease (cSVD); heart failure; coronary artery disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nucleic Acid Therapeutics: From Molecular Mechanisms to Delivery, Manufacturing, and Clinical Translation
edited by and
submission deadline 15 Oct 2026 | Viewed by 179 | Submission Open
Keywords: nucleic acid delivery; nanoparticle delivery systems; intracellular trafficking; endosomal escape; cellular metabolism; immunogenicity; process development
(This special issue belongs to the Section Molecular Pharmacology)
RNA Modification Databases and Bioinformatic Tools for Epitranscriptome Research
edited by and Yue Wang
submission deadline 17 Oct 2026 | Viewed by 230 | Submission Open
Keywords: epitranscriptomics; RNA modification; bioinformatics; computational tools; biological databases; machine learning; high-throughput sequencing; direct RNA sequencing; multi-omics integration; post-transcriptional regulation
(This special issue belongs to the Section Molecular Informatics)
Advancements in Hematology: Molecular Biology and Targeted Therapies
edited by Fabio Stagno and
submission deadline 20 Oct 2026 | 7 articles | Viewed by 21890 | Submission Open
Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapies and Strategies in the Treatment of Neurodegenerative Diseases submission deadline 20 Oct 2026 | 7 articles | Viewed by 21017 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; aging; memory; dementia; motor dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Precision Medicine: Unraveling Novel Mechanisms and Delivery Strategies in Complex Diseases
edited by
submission deadline 20 Oct 2026 | 6 articles | Viewed by 18833 | Submission Open
Keywords: molecular precision therapeutics; disease biomarkers; novel therapeutic molecules; drug delivery strategies; personalized medicine; bioinformatics; nanotechnology; synthetic biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondria: Central Players in Cancer submission deadline 20 Oct 2026 | 4 articles | Viewed by 16034 | Submission Open
Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapies for Melanoma
edited by Anna Piotrowska
submission deadline 20 Oct 2026 | 4 articles | Viewed by 14580 | Submission Open
Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Bioactive Compounds in Human Health
edited by
submission deadline 20 Oct 2026 | 8 articles | Viewed by 12451 | Submission Open
Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 12313 | Submission Open
Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights and Treatments for Gynecological Cancers submission deadline 20 Oct 2026 | 2 articles | Viewed by 11794 | Submission Open
Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Macro- and Micronutrients in Health and Diseases
edited by and Mariusz Gryko
submission deadline 20 Oct 2026 | 4 articles | Viewed by 11763 | Submission Open
Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases
(This special issue belongs to the Section Molecular Biology)
Bioactive Compounds of Natural Origin: 2nd Edition
edited by
submission deadline 20 Oct 2026 | 6 articles | Viewed by 10915 | Submission Open
Keywords: plants; extraction methods; bioactive compounds; natural products; application
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Oct 2026 | 5 articles | Viewed by 10402 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—2nd Edition
edited by
submission deadline 20 Oct 2026 | 3 articles | Viewed by 10358 | Submission Open
Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oxidative Stress Responses in Cardiovascular Diseases
edited by Vladimir Jakovljevic
submission deadline 20 Oct 2026 | 2 articles | Viewed by 10306 | Submission Open
Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition
edited by
submission deadline 20 Oct 2026 | 2 articles | Viewed by 9459 | Submission Open
Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Osteoarthritis Pathways and Biomarker Research
edited by
submission deadline 20 Oct 2026 | 6 articles | Viewed by 8664 | Submission Open
Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Micropollutants in Various Enviroments
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 8661 | Submission Open
Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality
(This special issue belongs to the Section Molecular Toxicology)
New Advances in Plant–Microbe Interaction submission deadline 20 Oct 2026 | 6 articles | Viewed by 8019 | Submission Open
Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases
edited by Tatsuji Nishihara
submission deadline 20 Oct 2026 | 4 articles | Viewed by 7840 | Submission Open
Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Adsorbing Materials
edited by Mounia Achak
submission deadline 20 Oct 2026 | 4 articles | Viewed by 7684 | Submission Open
Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications
(This special issue belongs to the Section Materials Science)
Molecular Research in Animal Nutrition
edited by Jie Fu
submission deadline 20 Oct 2026 | 7 articles | Viewed by 7522 | Submission Open
Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host–microbiome interaction; metabolic reprogramming
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition
edited by , María José Cuevas-González and Chun-Jung Huang
submission deadline 20 Oct 2026 | 4 articles | Viewed by 7480 | Submission Open
Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics
(This special issue belongs to the Section Molecular Biology)
Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications
edited by
submission deadline 20 Oct 2026 | 5 articles | Viewed by 7177 | Submission Open
Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect–plant interactions; environmental adaptation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Parasitic Infection
edited by Marcin Wiśniewski and
submission deadline 20 Oct 2026 | 6 articles | Viewed by 6848 | Submission Open
Keywords: parasitic infections; host–parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies
(This special issue belongs to the Section Molecular Microbiology)
HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis
edited by
submission deadline 20 Oct 2026 | 6 articles | Viewed by 6545 | Submission Open
Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions
(This special issue belongs to the Section Molecular Immunology)
RNA in Human Diseases: Challenges and Opportunities: 2nd Edition
edited by
submission deadline 20 Oct 2026 | 7 articles | Viewed by 6454 | Submission Open
Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification
(This special issue belongs to the Section Molecular Biology)
Fundamental and Translational Insights into Colorectal Cancer
edited by Giuseppe Broggi
submission deadline 20 Oct 2026 | 3 articles | Viewed by 6422 | Submission Open
Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Forest Tree Genetics, Breeding and Environmental Adaption
edited by and
submission deadline 20 Oct 2026 | 2 articles | Viewed by 6226 | Submission Open
Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Zebrafish Model for Neurological Research
edited by
submission deadline 20 Oct 2026 | 3 articles | Viewed by 6077 | Submission Open
Keywords: zebrafish ; Danio rerio ; brain ; nervous system
(This special issue belongs to the Section Molecular Neurobiology)
Metabolic Regulators of Bone Health
edited by
submission deadline 20 Oct 2026 | 3 articles | Viewed by 5658 | Submission Open
Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development
edited by and Halina Tkaczenko
submission deadline 20 Oct 2026 | 2 articles | Viewed by 5643 | Submission Open
Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors
edited by
submission deadline 20 Oct 2026 | 2 articles | Viewed by 5602 | Submission Open
Keywords: tyrosine kinase inhibitors; immunotherapy; monoclonal antibodies; CAR-T cells
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Orofacial Pain and Headache submission deadline 20 Oct 2026 | 4 articles | Viewed by 5313 | Submission Open
Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way submission deadline 20 Oct 2026 | 1 articles | Viewed by 5230 | Submission Open
Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets
edited by Souleymane Abdoul-Azize
submission deadline 20 Oct 2026 | 3 articles | Viewed by 5214 | Submission Open
Keywords: small-molecule drugs; signal transduction; therapeutic targets; therapeutic resistance; oncogenic signaling; novel biomarkers; cancer therapy; cancer signaling pathways; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Lipopolysaccharide in the Health and Disease
edited by and Hiroyuki Inagawa
submission deadline 20 Oct 2026 | 1 articles | Viewed by 4502 | Submission Open
Keywords: usefulness of LPS; oral and/or dermal administration of LPS; lifestyle disease; cognitive dysfunction; allergy; autoimmune disorder; wound healing; cancer
(This special issue belongs to the Section Biochemistry)
Biomechanics and Molecular Research on Glioblastoma: 2nd Edition
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 4401 | Submission Open
Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security
edited by and David Barry Sattelle
submission deadline 20 Oct 2026 | 2 articles | Viewed by 4170 | Submission Open
Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies
(This special issue belongs to the Section Molecular Biology)
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