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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research of Abiotic Stress in Plants
edited by Deguo Han
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1910 | Submission Open
Keywords: abiotic stress; salt stress; drought stress; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1872 | Submission Open
Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations
(This special issue belongs to the Section Molecular Neurobiology)
Autophagic Related Proteins in Cancer
edited by Pietri Puustinen
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1864 | Submission Open
Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth
(This special issue belongs to the Section Molecular Oncology)
Antimicrobial Peptides in Reproductive Health and Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1818 | Submission Open
Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair
edited by Anisa Shaker
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1754 | Submission Open
Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormone Receptor in Breast Cancer: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1730 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Oncology)
Treatment of Neurodegenerative Diseases with Natural Products
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1662 | Submission Open
Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
MicroRNAs and mRNA in Human Health and Disease
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1661 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1656 | Submission Open
Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Photosystem I (Second Edition) submission deadline 20 Dec 2025 | 1 articles | Viewed by 1635 | Submission Open
Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Gastrointestinal Cancer, 3rd Edition
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1571 | Submission Open
Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis
(This special issue belongs to the Section Molecular Oncology)
New Insights into Anticancer Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 1556 | Submission Open
Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Recent Research in Probiotic Yeasts: Molecular Aspects
edited by and Francesca Comitini
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1537 | Submission Open
Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds
(This special issue belongs to the Section Molecular Microbiology)
Sleep and Breathing: From Molecular Perspectives
edited by Alberto Alonso-Fernández
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1537 | Submission Open
Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics
(This special issue belongs to the Section Molecular Biology)
Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1504 | Submission Open
Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiac Repair and Regeneration: From Pathogenesis to Therapeutic Perspectives
edited by Marina Leone and Olaf Bergmann
submission deadline 20 Dec 2025 | Viewed by 1486 | Submission Open
Keywords: heart regeneration; cardiomyocyte proliferation; cell cycle; ischemic heart disease; myocardial infarction; stem cells; cardiac repair; polyploidization; tissue engineering; immune cells; metabolism; cell death  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1465 | Submission Open
Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Biocomposite Hydrogels for Biomedical Applications submission deadline 20 Dec 2025 | 1 articles | Viewed by 1435 | Submission Open
Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing
(This special issue belongs to the Section Materials Science)
Epilepsy: From Molecular Basis to Therapy, 2nd Edition submission deadline 20 Dec 2025 | 1 articles | Viewed by 1434 | Submission Open
Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structural Characterization and Pharmacological Activity of Natural Compounds
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1426 | Submission Open
Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Role of Ion Channels in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1397 | Submission Open
Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology
(This special issue belongs to the Section Molecular Biology)
Insights into Functional Nanomaterials: Application-Related Structural Analysis
edited by Zoltán Dudás
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1394 | Submission Open
Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials
(This special issue belongs to the Section Molecular Nanoscience)
Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1362 | Submission Open
Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Plant Reproductive Development
edited by Zsolt Pónya and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1292 | Submission Open
Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Virus-Host Immune Interactions
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1292 | Submission Open
Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2
(This special issue belongs to the Section Molecular Immunology)
The Role of Non-Coding RNAs in Female Reproduction
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1193 | Submission Open
Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network
(This special issue belongs to the Section Molecular Genetics and Genomics)
Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target submission deadline 20 Dec 2025 | 1 articles | Viewed by 1175 | Submission Open
Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer
(This special issue belongs to the Section Molecular Immunology)
Neural Stem Cells: Latest Applications and Future Perspectives submission deadline 20 Dec 2025 | 1 articles | Viewed by 1158 | Submission Open
Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease
(This special issue belongs to the Section Molecular Biology)
Regulatory Mechanisms Underlying Tumorigenesis
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1135 | Submission Open
Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models
(This special issue belongs to the Section Molecular Oncology)
Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects submission deadline 20 Dec 2025 | Viewed by 1122 | Submission Open
Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)
(This special issue belongs to the Section Molecular Pharmacology)
Ongoing Anticancer Agents
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1117 | Submission Open
Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies
(This special issue belongs to the Section Molecular Oncology)
Latest Molecular Research on Polymer Coatings
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1069 | Submission Open
Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.
(This special issue belongs to the Section Materials Science)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 918 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Cancer Stem Cells
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 913 | Submission Open
Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy
(This special issue belongs to the Section Biochemistry)
Proteases and Their Inhibitors: From Biochemistry to Applications
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 912 | Submission Open
Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention submission deadline 20 Dec 2025 | 1 articles | Viewed by 898 | Submission Open
Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Biomolecular Recognition: 3rd Edition
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 866 | Submission Open
Keywords: proteins; nucleic acids; membrane; ligand; binding
(This special issue belongs to the Section Molecular Biophysics)
Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications
edited by and Hiu Yee Kwan
submission deadline 20 Dec 2025 | 1 articles | Viewed by 850 | Submission Open
Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Protein Folding and Misfolding
edited by
submission deadline 20 Dec 2025 | Viewed by 832 | Submission Open
Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9
(This special issue belongs to the Section Molecular Biophysics)
25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics submission deadline 20 Dec 2025 | 1 articles | Viewed by 829 | Submission Open
Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography
(This special issue belongs to the Section Molecular Biophysics)
Electron Transport Mechanism in Optoelectronic Materials
edited by Paolo Umari
submission deadline 20 Dec 2025 | Viewed by 790 | Submission Open
Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport
(This special issue belongs to the Section Materials Science)
Biological Study of Plant Bioactive Compounds submission deadline 20 Dec 2025 | 1 articles | Viewed by 767 | Submission Open
Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Age-Related Cognitive Decline submission deadline 20 Dec 2025 | Viewed by 678 | Submission Open
Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes
(This special issue belongs to the Section Molecular Neurobiology)
Signaling in GPCR Research
edited by
submission deadline 20 Dec 2025 | Viewed by 659 | Submission Open
Keywords: GPCR; G protein; signaling; drug design; cell surface receptors
(This special issue belongs to the Section Biochemistry)
Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue
edited by
submission deadline 20 Dec 2025 | Viewed by 655 | Submission Open
Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting
(This special issue belongs to the Section Molecular Biology)
Molecular Studies of Skin Diseases: From Mechanisms to Therapy
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 649 | Submission Open
Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomolecular Condensates and Their Role in Cellular Organization and Disease
edited by Anna Bratek-Skicki
submission deadline 20 Dec 2025 | Viewed by 595 | Submission Open
Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases
(This special issue belongs to the Section Molecular Biology)
Red Blood Cells in Health and Disease
edited by Annamaria Russo and Ester Tellone
submission deadline 20 Dec 2025 | Viewed by 591 | Submission Open
Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes
(This special issue belongs to the Section Biochemistry)
Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads
edited by
submission deadline 20 Dec 2025 | Viewed by 564 | Submission Open
Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Fibrinolytic Factors in Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 521 | Submission Open
Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1
(This special issue belongs to the Section Molecular Biology)
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