Pancreatic Neuroendocrine Tumors: Current Evidence and Future Horizons

Dear Colleagues,

Pancreatic neuroendocrine tumors (PNETs) represent a heterogeneous group of neoplasms with increasing incidence over recent decades. Despite historically being considered indolent, a significant subset harbors aggressive behavior, posing diagnostic and therapeutic challenges. Advances in molecular profiling, imaging, and multimodal treatment strategies—including surgery, somatostatin analogues, targeted therapies, and peptide receptor radionuclide therapy (PRRT)—have substantially reshaped the clinical landscape.

This Special Issue aims to consolidate current evidence and explore emerging frontiers in PNET management, including novel biomarkers, optimal surgical strategies, the role of minimally invasive approaches, management of liver metastases, and the evolving molecular taxonomy guiding personalized treatment.

Original research articles, systematic reviews, and meta-analyses are welcome. Topics may include, but are not limited to, surgical resection and enucleation strategies; watch-and-wait policies for small PNETs; functional vs. non-functional tumors; PRRT outcomes; targeted molecular therapies; liquid biopsy and circulating biomarkers; and multidisciplinary management algorithms.

We look forward to receiving your contributions.

Dr. Roberto Cammarata
Guest Editor

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