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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bone and Cartilage Injury and Repair: Molecular Aspects

edited by Silvia María Díaz-Prado

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2944 | Submission Open

Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches

edited by Francisco Giner

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2934 | Submission Open

Keywords: coeliac disease; microscopic colitis; Crohn’ s disease; ulcerative colitis; microbiota; biological therapies; refractory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiota’s Role in Respiratory Disorders and Diseases

edited by

Ioannis Alexandros Charitos

and Mauro Carone

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2931 | Submission Open

Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation

(This special issue belongs to the Section Molecular Microbiology)

Synthetic Chemistry in Drug Discovery

edited by Kathiravan Suppan

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2897 | Submission Open

Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis

(This special issue belongs to the Section Molecular Pharmacology)

Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential

edited by

Gregory Christodoulidis

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2831 | Submission Open

Keywords: natural compounds; cancer research; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Radiobiology—New Advances

edited by

Marco Calvaruso

and

Luigi Minafra

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2773 | Submission Open

Keywords: radiobiology; radiotherapy; radiosensitizing agents; radioresistance; DNA damage; FLASH radiotherapy; particle therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Triple-Negative Breast Cancer: 2nd Edition

edited by

Yong-Moon Lee

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2755 | Submission Open

Keywords: triple negative breast cancer; lymph node metastasis; PMP22; prediction model using deep learning

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Treatment of Chronic Kidney Disease

edited by Xinming Chen

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2721 | Submission Open

Keywords: diabetes; cardiovascular diseases; nephrology; diabetic nephropathy

(This special issue belongs to the Section Molecular Biology)

Mitochondria and Energy Metabolism Reprogramming in Diseases

edited by

Nadège Bellance

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2702 | Submission Open

Keywords: mitochondrial dysfunctions; energy metabolism; pathophysiological mechanisms; therapeutic targets; physiology of organelle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

COVID-19: Molecular Research and Novel Therapy

edited by

Mihaela Chivu-Economescu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2621 | Submission Open

Keywords: SARS-CoV-2; virus-host interaction; immune response; antiviral agents; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of the Endocannabinoid System in Reward- and Addiction-Related Neuroplasticity

edited by

Francisco Navarrete-Rueda

and

María S. García Gutiérrez

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2611 | Submission Open

Keywords: endocannabinoid system; neuroplasticity; reward; addiction; biomarker; therapeutic approach

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Molecular Research in Cardiology and Treatment Approaches

edited by Ludger Hauck

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2610 | Submission Open

Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Luminescent Materials and Their Luminescence Mechanism

edited by

María Teresa Colomer

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2582 | Submission Open

Keywords: luminescence; molecular/ionic level; mechanism

(This special issue belongs to the Section Materials Science)

Molecular and Genomic Aspects of Viral Pathogens

edited by

Joanna Dąbrowska

submission deadline 20 Apr 2026 | 3 articles | Viewed by 2527 | Submission Open

Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction

(This special issue belongs to the Section Molecular Microbiology)

Explore Marine Biodiversity: Discover Insights from Genomics and Transcriptomics

edited by

Maria Sirakov

and Ambrosino Luca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2521 | Submission Open

Keywords: comparative genomics; functional genomics; transcriptomics; gene expression; adaptation; population genomics; marine biodiversity; evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Molecular Diagnostic Approaches for Neurodevelopmental Disorders: Applications and Future Perspectives

edited by

Barbara Lombardo

and Michele Pinelli

submission deadline 20 Apr 2026 | 3 articles | Viewed by 2417 | Submission Open

Keywords: neurodevelopmental disorders; array CGH; NGS

(This special issue belongs to the Section Molecular Neurobiology)

Zebrafish Model for Neurological Research

edited by

Mattia Toni

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2413 | Submission Open

Keywords: zebrafish ; Danio rerio ; brain ; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Peptide and Protein Drugs Against Infectious Diseases and Allergic Diseases

edited by

Xiumin Wang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2393 | Submission Open

Keywords: peptide and protein drugs; infectious diseases; allergic diseases; hormones; antimicrobial peptides; neuropeptides; cell-penetrating peptides; enzyme inhibitors; vaccines; antibodies

(This special issue belongs to the Section Molecular Pharmacology)

Current Trends in Redox Physiology Research

edited by Fotios Tekos

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2382 | Submission Open

Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Microbial Dynamics in Agroforestry for Resilience and Climate Adaptation

edited by

Amrita Chakraborty

and

Amit Roy

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2358 | Submission Open

Keywords: agroforestry; soil microbes; plant-microbe interactions; microbial influence; microbiomes; insect-microbe interactions; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights and Research on Nutrition and Obesity

edited by

Giovanna Bermano

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2347 | Submission Open

Keywords: nutrition; obesity; malnutrition; overnutrition; molecular and cellular mechanisms; nutrient– gene interactions; metabolic disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Ubiquitination and Deubiquitination in Plants

edited by

Hongyong Fu

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2177 | Submission Open

Keywords: ubiquitin; E1; E2; E3; deubiquitination; proteolysis; plants

(This special issue belongs to the Section Biochemistry)

Genetic Prediction of Risk of Common Diseases

edited by

Grant Morahan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2169 | Submission Open

Keywords: complex genetic diseases; cancer; heart disease; diabetes; dementia; polygenic risk score; genetic risk signatures

(This special issue belongs to the Section Molecular Genetics and Genomics)

Complex Interactions of Plants with Other Organisms: Particular Attention to Carnivorous and Parasitic Plants

edited by

Bartosz Płachno

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2142 | Submission Open

Keywords: carnivorous plants; parasitic plants; mycotrophic plants; hosts; phytochemistry; molecular biology; genome evolution; organ structure; cellular; genomic

(This special issue belongs to the Section Molecular Plant Sciences)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2138 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Advances in Microbial Genomics: Insights from Whole Genomes and Metagenomes

edited by

Marcos Quintela Baluja

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2070 | Submission Open

Keywords: microbial evolution; whole-genome sequencing; metagenomics; horizontal gene transfer; antimicrobial resistance; computational genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Mechanisms in Inflammatory Bowel Disease

edited by Michael Bording-Jorgensen

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2064 | Submission Open

Keywords: IBD; cytokines; microbiome; Crohn’ s disease; ulcerative colitis; dysbiosis; mucosal immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarker Discovery in Oral Diseases: Integrating Connected Health and Digital Biomarkers for Advanced Diagnostics and Personalized Care

edited by

Shahnawaz Khijmatgar

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2053 | Submission Open

Keywords: oral diseases; biomarker; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Advancements in Molecular Science, Material Analysis, and Surface Treatments: Paving the Way for Future Technological Innovations

edited by

Fadoua El-Hajjaji

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2039 | Submission Open

Keywords: materials; surface treatments; corrosion; nanomaterials; coatings; molecular interactions; deposition

(This special issue belongs to the Section Materials Science)

Multiple Sclerosis: Molecular Basis and New Therapy

edited by Vito A. G. Ricigliano

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2011 | Submission Open

Keywords: multiple sclerosis; inflammation; microglia; Epstein– Barr virus; neurodegeneration; remyelination; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets

edited by Kunie Ando and Jean-Pierre Brion

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1991 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative diseases; tau; amyloid; inflammation; disease modifying treatments; biomarkers; genetic variants; risk factors; mechanisms; protein– protein interactions; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Biochemical Advancements in Filler Technology and Their Impact on Tissue Engineering

edited by Samuel J. Lin

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1967 | Submission Open

Keywords: biochemical filler technology; tissue regeneration; bioactive materials; injectable scaffolds; molecular signaling in tissue engineering; biomaterials for soft tissue repair; filler– cell interactions; regenerative esthetics

(This special issue belongs to the Section Biochemistry)

Applications of Mass Spectrometry in the Analysis of Bioactive and Plant Organic Compounds

edited by

Marisabel Mecca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1937 | Submission Open

Keywords: mass spectrometry; VOCs; bioactive compounds; plant organic compounds; pharmaceutical research; metabolites

(This special issue belongs to the Section Biochemistry)

Pathogenic Proteins in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Innovations

edited by

Minseok Song

and

Nidhi Puranik

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1919 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; frontotemporal dementia; lewy bodies dementia; amyloid β -protein; τ -protein; α -synuclein; TDP-43; neurotransmitter; neuropeptide; protein misfolding; protein Homeostasis; neuroinflammatory proteins; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs

edited by Marta Chagas Monteiro,

Nélio Teixeira Machado

and Pedro Roosevelt Romão

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1916 | Submission Open

Keywords: waste biomass; thermochemical processes; bio-oils; phenolic compounds; anti-inflammatory actions; antiviral mechanisms; cancer; cytokine/chemokine regulation; inflammatory conditions/diseases; innate immunity; immune response; immunomodulatory and anti-infective effects; immunomodulation; immunotoxicology; medicinal chemistry; neglected tropical diseases; parasitic disease; purinergic signaling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Accelerating Therapeutic Innovation: Advances in Computer-Aided Drug Discovery

edited by Pietro Delre and

Antonio Lavecchia

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1904 | Submission Open

Keywords: CADD; drug discovery; machine learning; virtual screening; drug-target interaction

(This special issue belongs to the Section Molecular Informatics)

In Silico Approaches to Drug Design and Discovery

edited by

Alejandro Speck-Planche

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1891 | Submission Open

Keywords: chemoinformatics; computational de novo design and generative AI methods; machine learning; deep learning; molecular modeling; pharmacophore modeling; molecular docking; molecular dynamics; QSAR/QSPR; virtual screening

(This special issue belongs to the Section Molecular Informatics)

Molecular Biology and the Genetic Breeding of Aquatic Animals: Breakthroughs and Challenges (2nd Edition)

edited by

Hongyan Xu

submission deadline 20 Apr 2026 | 4 articles | Viewed by 1888 | Submission Open

Keywords: transgenic; genetic breeding; omics; gene expression and regulation; aquatic animals

(This special issue belongs to the Section Molecular Biology)

Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors

edited by

Walid Shalata

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1871 | Submission Open

Keywords: tyrosine kinase inhibitors; immunotherapy; monoclonal antibodies; CAR-T cells

(This special issue belongs to the Section Molecular Oncology)

Functional Polymeric Materials: From Synthesis to Applications: 2nd Edition

edited by

Marta Fernández-García

and

Alexandra Muñoz-Bonilla

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1860 | Submission Open

Keywords: natural polymers; bio-based polymers; block copolymers; micelles; polymer chemistry; (hydro)gels; (bio)applications; degradability

(This special issue belongs to the Section Materials Science)

New Insights into Lactoferrin: 2nd Edition

edited by

Antimo Cutone

and

Giovanni Musci

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1818 | Submission Open

Keywords: lactoferrin; lactoferrin structure; lactoferrin functions; infection; inflammation; iron homeostasis; oxidative stress; lactoferrin bioavailability

(This special issue belongs to the Section Molecular Immunology)

Heat Shock Proteins (HSPs): Biological Functions and Mechanisms of Actions

edited by

Soumya Patnaik

and

Gregory Blatch

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1812 | Submission Open

Keywords: heat shock proteins; apoptosis; immune cell activation; stress responses; misfolded proteins; cellular chaperones; cell signaling

(This special issue belongs to the Section Biochemistry)

Forest Tree Genetics, Breeding and Environmental Adaption

edited by

Jingli Yang

and

Huiyu Li

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1804 | Submission Open

Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Perspectives on the Synthesis and Application of Hydrogel Materials

edited by

Jieping Fan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1800 | Submission Open

Keywords: hydrogels; molecular basis; polymeric networks; supermolecular chemistry; three-dimensional structure; mechanical strength; rheologic properties; biomaterial

(This special issue belongs to the Section Materials Science)

Application of Mass Spectrometry and Chromatography in Drug Monitoring

edited by Carsten Müller

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1783 | Submission Open

Keywords: therapeutic drug monitoring; method validation; pharmacometrics; pediatric clinical pharmacology; laboratory developed tests; clinical mass spectrometry; functional tests; isobars; triple quad mass spectrometry; HR-MS; biomarker; drugs of abuse; therapeutic drugs; metabolites

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Neuroimaging

edited by

Chrissa Sioka

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1749 | Submission Open

Keywords: positron emission tomography pulmonary immunology; single photon emission computed tomography; artificial intelligence; neuro-oncology imaging; neurodegenerative disorders imaging; molecular neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Purinergic System

edited by Margarete Dulce Bagatini

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1739 | Submission Open

Keywords: purinergic system; receptors; ectonucleotidases; CD39; CD73; purinergic signaling

(This special issue belongs to the Section Biochemistry)

Interplay of Metabolism and Inflammation in Gastrointestinal Disease

edited by Marios N. Papadakis and

Stavros P. Papadakos

submission deadline 20 Apr 2026 | Viewed by 1736 | Submission Open

Keywords: gastrointestinal diseases; inflammation; metabolic dysregulation; metabolic processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1668 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Molecular Pathology and Next-Generation Biomarkers in Nephrology

edited by

Marijn Speeckaert

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1657 | Submission Open

Keywords: nephrology; genetic mutations; epigenetics; next-generation biomarkers; proteomics; metabolomics; single-cell sequencing; spatial transcriptomics; liquid biopsy; cfDNA; exosomes; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2751-2800 on page 56 of 70.

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