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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 20 May 2026 | 1 articles | Viewed by 1910 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition

edited by

Mattia Mori

and

Ilaria Vicenti

submission deadline 20 May 2026 | 2 articles | Viewed by 1795 | Submission Open

Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs

(This special issue belongs to the Section Molecular Pharmacology)

Antisense Oligonucleotides: Versatile Tools with Broad Applications

edited by

Suxiang Chen

submission deadline 20 May 2026 | 2 articles | Viewed by 1716 | Submission Open

Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Pathophysiology of Myocardial Disease, 2nd Edition

edited by

Ryan D. Sullivan

Inna P. Gladysheva

and Hongyu Qiu

submission deadline 20 May 2026 | 1 articles | Viewed by 1683 | Submission Open

Keywords: myocardial disease; cardiomyopathy; fibrosis and remodeling; inflammation; hypertension; heart failure; cardiometabolic; cardio-renal; heart-liver axis; comorbidity; molecular mechanisms; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Agents: Synthesis and Design

edited by

Silvana Alfei

submission deadline 20 May 2026 | 1 articles | Viewed by 1668 | Submission Open

Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles

(This special issue belongs to the Section Molecular Microbiology)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 20 May 2026 | 2 articles | Viewed by 1625 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genomics Advances in Behaviours

edited by

Péter Pikó

submission deadline 20 May 2026 | 1 articles | Viewed by 1617 | Submission Open

Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders

(This special issue belongs to the Section Molecular Biology)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 May 2026 | 1 articles | Viewed by 1597 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances and Mechanisms in Breast Cancer—2nd Edition

edited by

Ioannis Boutas

submission deadline 20 May 2026 | 2 articles | Viewed by 1583 | Submission Open

Keywords: breast cancer; genes and molecular pathways; targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatment in Gastrointestinal Cancers

edited by

Dani Ran Castillo

submission deadline 20 May 2026 | 1 articles | Viewed by 1579 | Submission Open

Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Osteoblast Differentiation in Human Health and Disease

edited by

Younho Han

submission deadline 20 May 2026 | 1 articles | Viewed by 1566 | Submission Open

Keywords: osteoblast differentiation; bone remodeling; mesenchymal stem cells; skeletal diseases; osteogenesis; bone mineralization; osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Novel Therapeutic Strategies for Cancers

edited by

Emanuela Grassilli

and

Maria Grazia Cerrito

submission deadline 20 May 2026 | 1 articles | Viewed by 1549 | Submission Open

Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Applications of Phytochemicals in Drug Synthesis

edited by

Gregorio Peron

submission deadline 20 May 2026 | 1 articles | Viewed by 1546 | Submission Open

Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Molecular Progression of Movement Disorders

edited by

Michał Latalski

and

Pilar Gomez-Garre

submission deadline 20 May 2026 | 1 articles | Viewed by 1513 | Submission Open

Keywords: movement disorders; molecular mechanisms; neurodegenerative diseases; therapeutic targets; biomarkers; neuroinflammation; protein misfolding; mitochondrial dysfunction; environmental factors; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition

edited by Sanja Dabelić

submission deadline 20 May 2026 | 2 articles | Viewed by 1513 | Submission Open

Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics

(This special issue belongs to the Section Macromolecules)

New Research on Bioactive Natural Products: 2nd Edition

edited by

Alexandros Tsoupras

submission deadline 20 May 2026 | 1 articles | Viewed by 1511 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Kidney Diseases—2nd Edition

edited by

Kan Katayama

submission deadline 20 May 2026 | 1 articles | Viewed by 1494 | Submission Open

Keywords: kidney disease; focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 20 May 2026 | 1 articles | Viewed by 1329 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Synthesis Manufacturing and Biomedical Applications of Nanofibers Scaffold

edited by

Marco Antonio Álvarez Pérez

and

Vincenzo Guarino

submission deadline 20 May 2026 | 1 articles | Viewed by 1326 | Submission Open

Keywords: scaffold manufacturing; nanofibers; 3D platforms; biohybrid scaffolds; biomolecules; functionalization; biomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Pancreatic Diseases: Molecular Pathology and Therapeutics

edited by

Maria Ines Vaccaro

submission deadline 20 May 2026 | 1 articles | Viewed by 1267 | Submission Open

Keywords: pancreatic cancer; acute pancreatitis; chronic pancreatitis; diabetes; inflammation; molecular markers; therapeutic strategies; genetic predispositions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Molecular Research on Pregnancy Complication Mechanisms

edited by

Aleksandra Stefanović

submission deadline 20 May 2026 | 1 articles | Viewed by 1235 | Submission Open

Keywords: hypertensive pregnancy disorders; gestational diabetes; intrauterine growth restriction; maternal metabolism in pregnancy complications; genetic and epigenetic mechanisms in pregnancy complications; immunology in pregnancy complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Multifunctional Magnetic Nanoparticles: Synthesis, Properties, and Biomedical Applications

edited by

Krishtappa Manjunatha

submission deadline 20 May 2026 | Viewed by 1202 | Submission Open

Keywords: magnetic nanoparticles; molecular functionalization; magnetocaloric materials; drug delivery systems; molecular imaging; magnetic memory; nanocomposites; nanophosphors; environmental remediation; energy storage materials; magnetic biosensing; biofunctional interfaces

(This special issue belongs to the Section Molecular Nanoscience)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 20 May 2026 | 2 articles | Viewed by 1173 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Eukaryotic DNA Replication—from Bench to Bedside

edited by Heinz-Peter Nasheuer

submission deadline 20 May 2026 | 1 articles | Viewed by 1171 | Submission Open

Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins— selection; licensing and firing; replication forks— smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 20 May 2026 | 1 articles | Viewed by 1170 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by

Natalia Nowacka-Jechalke

and

Marta Kinga Lemieszek

submission deadline 20 May 2026 | 2 articles | Viewed by 1168 | Submission Open

Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure– activity relationship; anticancer potential; immunomodulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Translational Preclinical Research

edited by

Mariano Gabri

submission deadline 20 May 2026 | 1 articles | Viewed by 1147 | Submission Open

Keywords: translational preclinical research; drug discovery; cancer therapies; in vitro and in vivo experiments; biological mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Electrochemical Nanomaterials for Energy and Catalysis

edited by

Sankar Sekar

submission deadline 20 May 2026 | 1 articles | Viewed by 1106 | Submission Open

Keywords: advanced micro- and nanomaterials for electrochemical applications; electrochemical energy storage; electrocatalysis; photoelectrochemical water splitting; electrochemical sensors; supercapacitor; batteries; nanocomposites and functionalized materials; energy storage and conversion application; natural resources-based materials

(This special issue belongs to the Section Molecular Nanoscience)

Analysis on Effector and Regulatory Molecules in Renal Diseases

edited by

Takashi Oda

submission deadline 20 May 2026 | 1 articles | Viewed by 1082 | Submission Open

Keywords: effector molecules; regulatory molecules; membrane attack complex (MAC); perforin; granzyme; immune complex; neutrophil extracellular traps (NETs); proteolytic enzymes; reactive oxygen species; infection-related glomerulonephritis (IRGN); nephritis-associated plasmin receptor (NAPlr); streptococcal pyrogenic exotoxin B (SPEB); adhesion molecules

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 20 May 2026 | 1 articles | Viewed by 1031 | Submission Open

Keywords: rare diseases; genotype– phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 20 May 2026 | 1 articles | Viewed by 1024 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 20 May 2026 | 2 articles | Viewed by 985 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

Current Advance in Infectious and Inflammatory Diseases

edited by

Justyna Agier

and

Paulina Żelechowska

submission deadline 20 May 2026 | 1 articles | Viewed by 940 | Submission Open

Keywords: inflammatory diseases; infectious diseases; host– pathogen interactions; antimicrobial resistance; immune modulation; cytokine signaling

(This special issue belongs to the Section Molecular Microbiology)

Surfactants: Design, Synthesis and Application

edited by

Urszula Bazylinska

submission deadline 20 May 2026 | 1 articles | Viewed by 926 | Submission Open

Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic– lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics

(This special issue belongs to the Section Materials Science)

Aquatic Organisms Models Dedicated to Disease

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 May 2026 | Viewed by 891 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Extracellular Vesicles in Disease and Therapeutic Applications

edited by Sunyoung Park

submission deadline 20 May 2026 | 1 articles | Viewed by 881 | Submission Open

Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Intrinsically Disordered Proteins (IDPs): From Structure to Mechanism and Function

edited by

Kyouhoon Han

submission deadline 20 May 2026 | Viewed by 873 | Submission Open

Keywords: IDP; NMR; completely unstructured; pre-structured; PreSMo; target binding

(This special issue belongs to the Section Biochemistry)

Synthesis and Application of Natural and Inspired-Natural Products

edited by Mauro de Nisco

submission deadline 20 May 2026 | 1 articles | Viewed by 826 | Submission Open

Keywords: natural products; natural substances; derivative; synthesis; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biological Study of Plant Bioactive Compounds

edited by

Anna Weronika Sobańska

submission deadline 20 May 2026 | 1 articles | Viewed by 822 | Submission Open

Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Roles of the Gut-Brain Axis (GBA) in Health and Disease

edited by Vinata Vedam-Mai

submission deadline 20 May 2026 | 1 articles | Viewed by 817 | Submission Open

Keywords: gut– brain axis; gut microbiota; brain function; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Insights into Antibacterial Material

edited by Rahela Carpa

submission deadline 20 May 2026 | 1 articles | Viewed by 773 | Submission Open

Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials

(This special issue belongs to the Section Materials Science)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 May 2026 | 1 articles | Viewed by 771 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling the Molecular Landscape of Primary Brain Tumors

edited by

Giuseppe Lombardi

, Francesco Pasqualetti and Tamara Ius

submission deadline 20 May 2026 | Viewed by 755 | Submission Open

Keywords: primary brain tumors; molecular oncology; glioma; glioblastoma; biomarkers; targeted therapy; epigenetics; tumor microenvironment; genomic profiling; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Current Research in Membrane Transporters, Channels, and Receptors

edited by Ivana Vrhovac Madunic

submission deadline 20 May 2026 | 1 articles | Viewed by 729 | Submission Open

Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging

(This special issue belongs to the Section Molecular Biology)

Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 May 2026 | Viewed by 693 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

The Role of Transcription Factors in Antioxidant Pathways

edited by

Eleonora Stanca

submission deadline 20 May 2026 | 1 articles | Viewed by 635 | Submission Open

Keywords: transcription factor; oxidative stress; NRF1/2; NRF3; NFkB; P53; antioxidant-response elements; neurologial diseases; metabolic diseases; cancer

(This special issue belongs to the Section Molecular Biology)

Chessboard: How Plants and Insects Outsmart Each Other

edited by

Mateusz Labudda

submission deadline 20 May 2026 | 1 articles | Viewed by 626 | Submission Open

Keywords: acarology; biotic stress; entomology nitric oxide; oxidative stress; phytopathology; reactive nitrogen species; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Approaches in Biomedicine: Innovations and Insights

edited by

Carlos Leon

submission deadline 20 May 2026 | Viewed by 608 | Submission Open

Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Repair Mechanisms of Stem Cells

edited by