Osteoblast Differentiation in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 297
Special Issue Editor
Special Issue Information
Dear Colleagues,
Osteoblast differentiation is a fundamental process in bone formation and remodeling, playing a crucial role in maintaining skeletal health throughout life. This complex biological process involves the transformation of mesenchymal stem cells into mature, bone-forming osteoblasts. Recent advancements in molecular biology, genetics, and cellular imaging have significantly enhanced our understanding of the mechanisms governing osteoblast differentiation. However, the dysregulation of this process is implicated in various skeletal disorders, including osteoporosis, osteoarthritis, and rare bone diseases, highlighting its importance in both health and disease states.
This Special Issue aims to provide a comprehensive overview of the latest research on osteoblast differentiation in human health and disease. We welcome original research articles, reviews, and perspectives that explore the molecular mechanisms, signaling pathways, and regulatory factors involved in osteoblast differentiation. Topics of interest include, but are not limited to, the role of transcription factors, epigenetic regulation, microRNAs, and extracellular matrix components in osteoblast differentiation. Additionally, we encourage submissions that investigate the impact of environmental factors, aging, and diseases on this process, as well as potential therapeutic strategies targeting osteoblast differentiation for skeletal disorder.
Prof. Dr. Younho Han
Guest Editor
Manuscript Submission Information
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Keywords
- osteoblast differentiation
- bone remodeling
- mesenchymal stem cells
- skeletal diseases
- osteogenesis
- bone mineralization
- osteoporosis
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