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Molecular and Genomics Advances in Behaviours

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 847

Special Issue Editor


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Guest Editor
Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Interests: molecular biology; lipidomic profile; genomics; metabolic syndrome; behaviours risk; physical activity
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Special Issue Information

Dear Colleagues,

The development of individual behaviors is determined by a combination of factors. Twin studies have shown that in addition to environmental and lifestyle factors, genomic factors have an important influence. An individual's behavior, whether healthy or unhealthy, affects their life at the molecular level. Such molecular changes have been linked to an increased risk of developing many diseases and their adverse, even fatal outcomes. Examples of such risk-increasing behaviors include smoking, alcohol consumption, and eating and sleeping disorders, while a physically active lifestyle, for example, has a risk-reducing effect.

Submissions are invited for inclusion in the International Journal of Molecular Sciences Special Issue on "Molecular and Genomics Advances in Behaviours". This Special Issue will bring together cutting-edge research from the fields of molecular and genomic research to help us to understand the processes and relationships underlying different behaviors. We encourage the submission of original research articles, reviews, and short communications that address different aspects of the molecular and genomic bases of behavior. This Special Issue focuses primarily on human research but does not preclude the presentation of results from experiments on animals that model human behavior.

Dr. Péter Pikó
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • unhealthy and healthy behaviors
  • smoking
  • sleeping
  • eating
  • alcoholism
  • gambling
  • aggression
  • addictive behaviors
  • physical activity
  • mental disorders

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Published Papers (1 paper)

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Research

17 pages, 881 KB  
Article
The Impact of Smoking-Associated Genetic Variants on Post-Exercise Heart Rate
by Habib Al Ashkar, Nihad Kharrat Helu, Nora Kovacs, Szilvia Fiatal, Roza Adany and Peter Piko
Int. J. Mol. Sci. 2025, 26(18), 8787; https://doi.org/10.3390/ijms26188787 - 9 Sep 2025
Viewed by 360
Abstract
Smoking has a well-established impact on cardiovascular health, notably through elevated resting heart rate and impaired autonomic regulation—both key risk factors. While nicotine’s acute effects are well documented, the influence of smoking-related genetic variants on heart rate (HR) responses remains unclear. This study [...] Read more.
Smoking has a well-established impact on cardiovascular health, notably through elevated resting heart rate and impaired autonomic regulation—both key risk factors. While nicotine’s acute effects are well documented, the influence of smoking-related genetic variants on heart rate (HR) responses remains unclear. This study investigated the association between selected smoking-related single nucleotide polymorphisms (SNPs) and HR dynamics following physical exertion. A total of 661 Hungarian adults completed the YMCA 3 min step test, with HR measured at rest, immediately post-exercise, and during recovery at 5 and 10 min. Key indices included post-exercise HR (HRaft), HR change (ΔHR), maximum HR percentage (HRmax%), and heart rate recovery coefficient (HRR). Genetic analysis focused on nine SNPs previously linked to smoking behaviours, with a composite genetic risk score derived from the three most influential variants (rs2235186, rs4142041, and rs578776). Associations were examined using adjusted linear regression. No significant relationship was found between any individual SNP and resting HR. However, rs2235186, rs4142041, and rs578776 were consistently associated with elevated HRaft, increased ΔHR, higher HRmax%, and slower HRR. The genetic risk score showed significant correlations with all post-exercise HR measures, suggesting a cumulative genetic effect. These findings indicate that smoking-related genetic predisposition may influence autonomic cardiovascular responses to physical activity. Although resting HR remains unaffected, specific SNPs are linked to post-exercise HR dynamics and recovery, highlighting the potential value of genetic screening in personalised cardiovascular risk assessment among smokers. Full article
(This article belongs to the Special Issue Molecular and Genomics Advances in Behaviours)
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