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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Role of Cytoskeletal Proteins in Diseases

edited by

Urko Del Castillo

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3633 | Submission Open

Keywords: cytoskeleton; microtubules; actin filaments; intermediate filaments; neurodegeneration; cancer metastasis; cell migration; cellular mechanotransduction; cytoskeletal remodeling

(This special issue belongs to the Section Molecular Biology)

Molecular Tools in Environmental Microbiology

edited by

Živilė Strazdaitė-Žielienė

and

Juliana Lukša

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3627 | Submission Open

Keywords: environmental microbiology; molecular methods; microbial community analysis; low-abundance microorganisms; microbial identification; environmental DNA; next-generation sequencing (NGS); high-throughput sequencing

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanisms of Prostate Cancer

edited by

Estefania Labanca

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3598 | Submission Open

Keywords: genetic alterations; signlaing pathways; cellular dysregulation; non-coding RNAs; epigenetics; tumor microenvironment; metabolic factors; therapuetic targeting; multi-modal approaches

(This special issue belongs to the Section Molecular Oncology)

Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models

edited by

Oleksii Skorokhod

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3486 | Submission Open

Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation

edited by

Edyta Juszczuk-Kubiak

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3416 | Submission Open

Keywords: probiotics; gut microbiota; gut–brain axis; mental health

(This special issue belongs to the Section Molecular Biology)

Gene Regulation in Endocrine Disease, 2nd Edition

edited by

Alberto Falchetti

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3374 | Submission Open

Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Complement Regulation in Kidney Disease

edited by Jasmina Marković Lipkovski

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3332 | Submission Open

Keywords: complement system; kidney disease; glomerulonephritis; C3 glomerulopathy; membranous nephropathy; complement regulation; innate immunity; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Physiological Strategies for Plant Drought Resilience

edited by

Mariapina Rocco

submission deadline 25 Dec 2026 | 1 articles | Viewed by 3306 | Submission Open

Keywords: abiotic stress; reactive oxygen species; oxidative stress; adaptive response; signaling pathways; phytohormones; physiological adaptation; molecular adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (3rd Edition)

edited by

Maoteng Li

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3295 | Submission Open

Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Molecular Advances in Prostate Cancer

edited by Rejane Maira Góes

submission deadline 25 Dec 2026 | 2 articles | Viewed by 3231 | Submission Open

Keywords: prostate cancer; androgen signaling; metabolic reprogramming; tumor microenvironment; inflammation; immunotherapy; chemoprotection; phytotherapy

(This special issue belongs to the Section Molecular Oncology)

Plant Extracts and Natural Products: Molecular Insights into the Biofunctional Properties

edited by

Komgrit Eawsakul

and

Chawan Manaspon

submission deadline 25 Dec 2026 | 6 articles | Viewed by 3029 | Submission Open

Keywords: plant-derived bioactive compounds; molecular mechanisms and signaling pathways; drug delivery systems; bioavailability enhancement; multi-omics platforms; network pharmacology and molecular docking; cellular targets and receptor interactions; natural product drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gut Microbiota-Derived Metabolites in Human Health and Disease

edited by Zeneng Wang

submission deadline 25 Dec 2026 | 3 articles | Viewed by 3014 | Submission Open

Keywords: microbiome; microbiota; gut; metabolomics; health; disease; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Antimicrobial Agents: Mechanisms and Applications

edited by

Aleksandra Maria Kocot

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2951 | Submission Open

Keywords: antimicrobial compounds; antibacterial activity; antibiotic resistance; pathogen-tailored therapeutic targeting; novel antimicrobials; molecular aspects of the mechanisms of action of antibacterial substances; effectiveness of antibacterial substances

(This special issue belongs to the Section Biochemistry)

Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management

edited by

James Alan Bourgeois

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2933 | Submission Open

Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2921 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology, 3D research, and diagnostic systems; evolving 3D “omics” applications; research and clinical medicine; drug applications; toxicity evaluations; “Omics” ; spatial biology of 3D

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Biomaterials for Tissue Regeneration

edited by

Liviu Duta

and

Valentina Grumezescu

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2893 | Submission Open

Keywords: biomaterials; tissue regeneration; molecular mechanisms; cell-instructive scaffolds; injectable hydrogels; ECM-mimetic materials; bioactive ceramics; bioactive surface coatings; mechanotransduction/mechanobiology; immunomodulation; angiogenesis and vascularization; biofabrication (3D/4D printing)

(This special issue belongs to the Section Materials Science)

Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets

edited by

Alexandr Ceasovschih

Victoriţa Şorodoc

and

Yusuf Ziya Şener

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2857 | Submission Open

Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Genome-Edited Animal Models

edited by Takayuki Sakurai and

Masahiro Sato

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2856 | Submission Open

Keywords: genome editing; prime editing; base editing; CRISPRa/CRISPRi; knock-in/out; conditional genome editing; multiplex genome editing; manipulation of early embryos and germ cells; in vivo gene delivery; genome-edited animals; disease animal model

(This special issue belongs to the Section Molecular Genetics and Genomics)

Progress in Prevention and Treatment of Cardiovascular Diseases and Arrhythmias

edited by

Narcis Tribulova

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2832 | Submission Open

Keywords: translational research; novel animal models; novel treatment targets; pleiotropic drugs; harnessing of molecular H

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modern Approaches in Regenerative Therapy

edited by

Daria Chudakova

and

Vladimir P. Baklaushev

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2827 | Submission Open

Keywords: regenerative therapy; regeneration; neuroregeneration; cell reprogramming; cell therapy; regenerative bio-scaffolds; extracellular vesicles; mesenchymal stromal/stem cells (MSCs); cell differentiation; omics technologies

(This special issue belongs to the Section Molecular Biology)

Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity

edited by Bourlaye Fofana and

Champa Wijekoon

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2802 | Submission Open

Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity

(This special issue belongs to the Section Molecular Plant Sciences)

Toxicology Research: Understanding and Predicting Compound—Induced Toxicity

edited by

Georgios Pampalakis

and

Eleni Zingkou

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2733 | Submission Open

Keywords: molecular toxicology; emerging toxicology; drug-induced toxicity; organ toxicology; animal models; in silico toxicology; in vitro models; pesticides; industrial chemicals

(This special issue belongs to the Section Molecular Toxicology)

Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery

edited by

Adelina-Gabriela Niculescu

and

Alexandra Catalina Birca

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2620 | Submission Open

Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine

(This special issue belongs to the Section Molecular Nanoscience)

Genetic Variations in Human Diseases: 3rd Edition

edited by

Paweł Niemiec

submission deadline 25 Dec 2026 | 4 articles | Viewed by 2564 | Submission Open

Keywords: genetic polymorphism; gene–gene interaction; gene–environment interaction; monogenic disorder; mutation phenotype; quantitative trait locus; family-based study; cohort study; association study

(This special issue belongs to the Section Molecular Genetics and Genomics)

Organoid Models in Host–Pathogen Interactions and Disease Pathogenesis

edited by

Apichai Tuanyok

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2545 | Submission Open

Keywords: organoids; host–pathogen interaction; infectious disease models; mucosal immunity; tissue engineering; microbial pathogenesis; immune organoids; 3D culture systems

(This special issue belongs to the Section Molecular Biology)

Exploring the Interplay Between Food Components and the Gut: From Mechanisms to Microbiome Interaction

edited by

Mattia Di Nunzio

and Lorenzo Nissen

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2537 | Submission Open

Keywords: intestinal cells; nutrients; in vitro digestion; nutrigenomics; nutrigenetics; gut microbiota

(This special issue belongs to the Section Molecular Microbiology)

Preimplantation Genetic Testing in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2532 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research and Immune Landscape of Breast Cancer

edited by

Robson Monteiro

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2460 | Submission Open

Keywords: breast cancer; immune landscape; single-cell analysis; omics; therapy resistance; metastasis

(This special issue belongs to the Section Molecular Immunology)

New Advances in Metal Nanoparticles

edited by

Emilia Konował

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2458 | Submission Open

Keywords: metal nanoparticles; molecular-level mechanisms; functional nanostructures; environmental nanotechnology; nanoparticle stability; catalysis; hybrid nanomaterials; bimetallic systems; ligand–nanoparticle interactions

(This special issue belongs to the Section Molecular Nanoscience)

Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses and Therapies

edited by Magdalena Wawrzyńska

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2447 | Submission Open

Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Immunodeficiency and Immunotherapy in Multiple Myeloma

edited by

Marjorie Pick

and

Eyal Lebel

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2423 | Submission Open

Keywords: multiple myeloma; plasma cells; monoclonality; immunodeficient

(This special issue belongs to the Section Molecular Immunology)

Antibacterial Nanomaterials for Medicinal Applications

edited by

Tsung-Rong Kuo

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2404 | Submission Open

Keywords: nanotechnology; antibacterial; nanomaterials; toxicity; biocompatibility; medicinal applications

(This special issue belongs to the Section Molecular Nanoscience)

Viral Infections and Viral Pathogenesis

edited by

Shymaa E. Bilasy

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2400 | Submission Open

Keywords: viral pathogenesis; viral–host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy

(This special issue belongs to the Section Molecular Microbiology)

Advances in Electrochemical Nanomaterials for Energy and Catalysis

edited by

Sankar Sekar

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2372 | Submission Open

Keywords: advanced micro- and nanomaterials for electrochemical applications; electrochemical energy storage; electrocatalysis; photoelectrochemical water splitting; electrochemical sensors; supercapacitor; batteries; nanocomposites and functionalized materials; energy storage and conversion application; natural resources-based materials

(This special issue belongs to the Section Molecular Nanoscience)

Sarcomas: From Molecular Signatures to Morphologic Patterns

edited by

Isidro Machado

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2366 | Submission Open

Keywords: sarcomas; histopathology; molecular pathology; FISH; gene fusion in sarcomas

(This special issue belongs to the Section Molecular Oncology)

Molecular Aspects of Tumor Radiotherapy

edited by

Johann Matschke

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2309 | Submission Open

Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies

(This special issue belongs to the Section Molecular Oncology)

New Advances in Reproductive Immunology and Pathology

edited by Silvia Giugliano

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2303 | Submission Open

Keywords: maternal–fetal immune tolerance; reproductive immunopathology; cytokine signaling in pregnancy; immune-related infertility; metabolome-immune crosstalk; microbiome influence on fertility

(This special issue belongs to the Section Molecular Immunology)

Molecular Informatics and AI in Cancer Research

edited by

Nabil Adam

and

Robert Wieder

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2280 | Submission Open

Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data

(This special issue belongs to the Section Molecular Informatics)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases

edited by

Eiko Nakamaru-Ogiso

submission deadline 25 Dec 2026 | 1 articles | Viewed by 2197 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Machine Learning in Disease Diagnosis and Treatment: 2nd Edition

edited by

Makrina Karaglani

submission deadline 25 Dec 2026 | 2 articles | Viewed by 2161 | Submission Open

Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapies of Pancreatic Cancer: 3rd Edition

edited by

Donatella Delle Cave

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2107 | Submission Open

Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Autoimmune Diseases: The Molecular Basis and New Therapies

edited by

Adawi Mohammad

submission deadline 25 Dec 2026 | 3 articles | Viewed by 2098 | Submission Open

Keywords: autoimmunity; molecular mechanisms; biologics; immunotherapy; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular Crosstalk in Stress-Induced Psychopathology

edited by Ilaria Demori and

Natalia V. Gulyaeva

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1993 | Submission Open

Keywords: Depression; Anxiety; Post-traumatic stress disorder; Early life stress; Microbiota–gut–brain axis; Blood–brain barrier; Neurotransmission; Neuroinflammation; Eating disorders; Addiction; Psychoneuroendocrineimmunology; Allostasis

(This special issue belongs to the Section Molecular Neurobiology)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1984 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Breast Cancer and Hormone Receptors: Molecular Insights

edited by

Alkistis Papatheodoridi

and

Antonella Muscella

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1967 | Submission Open

Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Advances in Cancer Epigenetics for Precision Medicine

edited by

Alessandro Lavoro

and

Saverio Candido

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1949 | Submission Open

Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs

(This special issue belongs to the Section Molecular Oncology)

Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies

edited by

Emanuela Pessolano

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1935 | Submission Open

Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)

edited by

Karolina Orywal

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1919 | Submission Open

Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Aspects of Cancer Stem Cell Biology and Their Therapeutic Implications

edited by

Tanja Matijevic Glavan

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1884 | Submission Open

Keywords: cancer stem cells; chemotherapy; radiotherapy; transcription factors; stemness properties; chemoresistance; radioresistance

(This special issue belongs to the Section Molecular Oncology)

Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1883 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 1451-1500 on page 30 of 63.

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