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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Associations Between Adipose Tissue and Diseases submission deadline 20 Feb 2026 | 2 articles | Viewed by 2326 | Submission Open
Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms submission deadline 20 Feb 2026 | 1 articles | Viewed by 2299 | Submission Open
Keywords: lung cancer; NSCLC; cancer therapy; resistance; DNA methylation
(This special issue belongs to the Section Molecular Oncology)
Environmental Heavy Metals with Their Benefits and Risks for Human Health
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2287 | Submission Open
Keywords: heavy metals; metal compound; iron; copper; cadmium; arsenic; oxidative stress; cell death; toxicology; Wilson disease; hemochromatosis
(This special issue belongs to the Section Molecular Toxicology)
Pathophysiological Insights, Biomarkers and New Therapeutic Strategies in Immune-Mediated Disorders and Neurodegenerative Diseases
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2272 | Submission Open
Keywords: neurodegeneration; neuroimmunology; inflammation; biomarkers; treatment; pathophysiology; multiple sclerosis; myasthenia gravis; neurodegenerative disease
(This special issue belongs to the Section Molecular Immunology)
Stem Cells Research: Advancing Science and Medicine
edited by Susana Rosa
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2239 | Submission Open
Keywords: stem cell; stem cell biology; stem cell-based therapies; regenerative medicine; disease modeling
(This special issue belongs to the Section Biochemistry)
Zebrafish: A Model Organism for Human Health and Disease: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2219 | Submission Open
Keywords: zebrafish; drug discovery; high-throughput screens; genome editing/CRISPR mutants; cancer; neuronal disorders; drug toxicity; drug effect mechanisms; developmental disorders
(This special issue belongs to the Section Molecular Biology)
Advances in Metabolic Phenotypes of Pediatric Obesity
edited by Simona Georgiana Popa
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2186 | Submission Open
Keywords: cardiometabolic phenotypes of pediatric obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Insights into the Antibacterial Effect of Nano- and Micro-Materials submission deadline 20 Feb 2026 | 1 articles | Viewed by 2177 | Submission Open
Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Functions of Extracellular Vesicles
edited by and Jameel M. Inal
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2157 | Submission Open
Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical
(This special issue belongs to the Section Molecular Biology)
The Impact of Biomolecules on the Pathogenesis of Oral and Periodontal Diseases
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2131 | Submission Open
Keywords: biomolecules; inflammatory mediators; enzymes; cytokines; dysbiosis; microbiome; genetic and epigenetic factors; oral and periodontal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Micropollutants in Various Enviroments
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2114 | Submission Open
Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality
(This special issue belongs to the Section Molecular Toxicology)
Advanced Molecular Research in Brain Tumors
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2110 | Submission Open
Keywords: targeted therapy; blood– brain barrier; GBM; glioma; immune checkpoint blockers; TME
(This special issue belongs to the Section Molecular Oncology)
Protein Kinase in Disease, 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 2021 | Submission Open
Keywords: protein kinases; phosphorylation; cancers; inflammatory diseases; protein kinase inhibitors; anticancer drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders
edited by Massimiliano M. Corsi Romanelli and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2012 | Submission Open
Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms of Phytochemicals in Antioxidation, Antimicrobial, and Cytoprotective Properties
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1999 | Submission Open
Keywords: phytochemicals; antioxidant; antimicrobial; cytoprotective; in vitro screening; in vivo evaluation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Diagnosis and Treatment of Migraine
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1979 | Submission Open
Keywords: migraine; pathophysiology; diagnostics; therapy; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Heart Failure: From Bench to Bedside
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1896 | Submission Open
Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Acute Kidney Injury: Molecular Mechanism and Targeted Therapeutic Approaches
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1855 | Submission Open
Keywords: kidney injury; repair; immunoresponse; biomarker; targeted therapy; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition) submission deadline 20 Feb 2026 | 1 articles | Viewed by 1814 | Submission Open
Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways
(This special issue belongs to the Section Molecular Oncology)
Plant Metabolism and Natural Product Biosynthesis
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1803 | Submission Open
Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Exploring the Genetics in Rare Diseases: A Genomic Odyssey
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1783 | Submission Open
Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Dyslipidemia submission deadline 20 Feb 2026 | 2 articles | Viewed by 1749 | Submission Open
Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Developing Chiral Products: New Progression in Separation, Synthesis, and Application
edited by István Ilisz
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1743 | Submission Open
Keywords: chirality; enantioselective separations; chiral selector molecules; chiral stationary phases; chiral sensors; enantiorecognition; chiral separation mechanisms
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1720 | Submission Open
Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems
(This special issue belongs to the Section Biochemistry)
New Advances in Cystinosis from Basic to Clinical Research
edited by Francesco Bellomo
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1694 | Submission Open
Keywords: cystinosis; kidney; Fanconi syndrome; muscles; eyes; autophagy; bioenergetics; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ruminant Physiology: Digestion, Metabolism, and Endocrine System
edited by Rui Hu
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1673 | Submission Open
Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Toxicological Impacts of Emerging Contaminants on Aquatic Organisms
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1642 | Submission Open
Keywords: aquatic toxicology; emerging contaminants; physiology and behavior; oxidative stress; antioxidant biomarkers; immunotoxicity; neuroendocrine toxicity; bioremediation; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Molecular Biology of Periodontal Disease and Periodontal Pathogens
edited by Yago Leira and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1619 | Submission Open
Keywords: periodontitis; general medicine; inflammation; bacteraemia; education
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Liver Health: State of the Art and Recent Research Advances
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1614 | Submission Open
Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition
edited by , María José Cuevas-González and Chun-Jung Huang
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1576 | Submission Open
Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics
(This special issue belongs to the Section Molecular Biology)
Research on Alloy Materials Microstructure and Their Functionalization
edited by and Celaletdin Ergun
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1569 | Submission Open
Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites
(This special issue belongs to the Section Materials Science)
Gynecological Oncology: From Molecular Basis to Therapy
edited by and Lars Hanker
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1566 | Submission Open
Keywords: gynecological oncology; molecular basis; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Tumorigenesis of Human and Animal Stem Cells
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1539 | Submission Open
Keywords: malignancy; stem cells; safety; chromosal aberrations; animal; human; teratoma assay; in vitro assays
(This special issue belongs to the Section Molecular Oncology)
Bioactive Natural Compounds in Neuroscience
edited by
submission deadline 20 Feb 2026 | Viewed by 1525 | Submission Open
Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Parasitic Infection
edited by Marcin Wiśniewski and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1460 | Submission Open
Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies
(This special issue belongs to the Section Molecular Microbiology)
Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications
edited by Maria Rosaria Tumolo and Saverio Sabina
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1435 | Submission Open
Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches
(This special issue belongs to the Section Molecular Informatics)
Biomechanics and Molecular Research on Glioblastoma: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1434 | Submission Open
Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer submission deadline 20 Feb 2026 | 2 articles | Viewed by 1429 | Submission Open
Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies
(This special issue belongs to the Section Molecular Oncology)
Molecular Research and Insight in Neurotransmission and Neuromodulation
edited by Miklos Jaszberenyi
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1427 | Submission Open
Keywords: histology; microanatomy; morphology; molecular biology; neurotransmitter; neuromodulator; neuropeptide; neurohormone; nervous system
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Vitiligo: From Mechanisms to Treatment Innovations
edited by Hyun Jeong Ju
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1396 | Submission Open
Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Interactions and Advanced Computational Methods for Biomolecular Systems
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1389 | Submission Open
Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques
(This special issue belongs to the Section Molecular Biophysics)
The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations submission deadline 20 Feb 2026 | 1 articles | Viewed by 1378 | Submission Open
Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research on Plant-Derived Products in the Service of Immune Regulation submission deadline 20 Feb 2026 | 1 articles | Viewed by 1365 | Submission Open
Keywords: plant bioactive compound; inflammation; immunity; cytokine; chronic disease
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience
edited by Matteo Di Segni and Rossella Ventura
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1341 | Submission Open
Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness
(This special issue belongs to the Section Molecular Neurobiology)
Microbiome-Immunity Crosstalk and Its Role in Health and Disease
edited by and Sara Uceda
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1336 | Submission Open
Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases
(This special issue belongs to the Section Molecular Microbiology)
Study on the Microenvironment in Lymphoma submission deadline 20 Feb 2026 | 2 articles | Viewed by 1271 | Submission Open
Keywords: tumor microenvironment; lymphoma; hodgkin lymphoma; non-hodgkin lymphoma; burkitt lymphoma; follicular lymphoma; waldenströ m’ s macroglobulinemia; NK/T-cell lymphoma; diffuse large B-cell lymphoma; mantle cell lymphoma; marginal zone lymphoma; lymphoproliferative disorder; anaplastic large cell lymphoma; mediastinal B cell lymphoma; T-cell lymphomas
(This special issue belongs to the Section Molecular Oncology)
The Toxicity of Bisphenol A and Its Analogs
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1235 | Submission Open
Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology
(This special issue belongs to the Section Molecular Toxicology)
Novel Insights into Buckwheat Reproductive Biology
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1173 | Submission Open
Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield
(This special issue belongs to the Section Molecular Plant Sciences)
The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development
edited by and Halina Tkaczenko
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1032 | Submission Open
Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Cancer Progression and Therapeutic Resistance Mechanisms
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1021 | Submission Open
Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds
(This special issue belongs to the Section Molecular Oncology)
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