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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Imaging for Cancer Theranostics

edited by

Hak Soo Choi

and Kai Bao

submission deadline 20 Apr 2027 | 3 articles | Viewed by 8348 | Submission Open

Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Antibacterial Materials for Medical Applications

edited by

Shixiong Yi

submission deadline 20 Apr 2027 | 2 articles | Viewed by 2153 | Submission Open

Keywords: biomaterial science; photodynamic antibacterial materials; photothermal antibacterial materials; advanced antibacterial materials; antimicrobial nanostructured materials; polymer-based biomaterials; infected wound dressings

(This special issue belongs to the Section Materials Science)

Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies

edited by

Xingkang Wu

submission deadline 20 Apr 2027 | 1 articles | Viewed by 1101 | Submission Open

Keywords: immune microenvironment; cell proliferation; molecular mechanisms; therapeutic strategies; tumor; autoimmune disease; psoriasis; rheumatoid arthritis; lupus erythematosus; type 1 diabetes; inflammatory bowel disease

(This special issue belongs to the Section Molecular Immunology)

Biomaterials for Dental and Orthopedic Applications, 2nd Edition

edited by

Lia Rimondini

submission deadline 20 Apr 2027 | 1 articles | Viewed by 1037 | Submission Open

Keywords: personalized biomaterials; dental and orthopedic applications; tissue regeneration; 3D biorinting

(This special issue belongs to the Section Materials Science)

Multidrug-Resistant Bacteria Across One Health Interfaces: Molecular Mechanisms, Dissemination, and Innovative Control Strategies

edited by

Clara Mariana Gonçalves Lima

submission deadline 20 Apr 2027 | Viewed by 45 | Submission Open

Keywords: antimicrobial resistance; virulence factors; biofilms; multidrug-resistant bacteria; antimicrobial agents

(This special issue belongs to the Section Molecular Microbiology)

Integrative Multi-Omics in Neurodegenerative Diseases: Mechanisms, Biomarkers and Therapeutic Targets

edited by

Abdullah Sheikh

submission deadline 20 Apr 2027 | Viewed by 40 | Submission Open

Keywords: multi-omics; neurodegenerative diseases; systems biology; biomarkers; precision medicine; transcriptomics; proteomics; metabolomics; epigenomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment (3rd Edition)

edited by

Vincenzo Fiorentino

and

Maurizio Martini

submission deadline 20 Apr 2027 | Viewed by 9 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid–gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cellular and Molecular Mechanisms in the Progression of Cardiovascular Diseases

edited by

Eglė Mazgelytė

submission deadline 22 Apr 2027 | Viewed by 73 | Submission Open

Keywords: cardiovascular diseases; molecular mechanisms; cellular signaling; inflammation; oxidative stress; cardiac remodeling; endothelial dysfunction; biomarkers; precision medicine; translational cardiovascular research

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics and Genomics of Aquatic Crustaceans

edited by

Xianhong Meng

Falin Zhou

and Lingbo Ma

submission deadline 23 Apr 2027 | 4 articles | Viewed by 3811 | Submission Open

Keywords: genome sequencing; epigenomics; CRISPR/Cas9 gene editing; transcriptomics; gene expression profiling; genome-wide association studies (GWASs); quantitative trait loci (QTL) mapping; genomic selection; marker-assisted selection (MAS); molecular markers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition

edited by

Zhidong Zhou

and

Alexandre Hiroaki Kihara

submission deadline 23 Apr 2027 | 1 articles | Viewed by 1303 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Biology of Haematology

edited by Valéria Tavares

submission deadline 23 Apr 2027 | 1 articles | Viewed by 881 | Submission Open

Keywords: haematopoiesis; molecular biology; genomics; epigenomics; computational biology; hematologic neoplasms; biomarkers; liquid biopsy; precision medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Innate Immunity and Disease Resistance in Animals

edited by

Sutian Wang

submission deadline 23 Apr 2027 | Viewed by 485 | Submission Open

Keywords: innate immunity; pathogenic microorganism; animals; pathogenesis; mechanism of disease-resistance; disease-resistant/therapeutic target

(This special issue belongs to the Section Molecular Immunology)

Biosynthetic Pathways, Regulation, and Metabolic Engineering of Plant Bioactive Compounds

edited by

Fei Zhou

submission deadline 25 Apr 2027 | Viewed by 15 | Submission Open

Keywords: plant bioactive compounds; specialized metabolism; biosynthetic pathways; metabolic regulation; metabolic engineering; synthetic biology; heterologous production; multi-omics

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Biomarkers and Therapeutics for Alzheimer's Disease

edited by

Lindsay H. Burns

submission deadline 28 Apr 2027 | Viewed by 11 | Submission Open

Keywords: Alzheimer’s disease; biomarkers; neuroprotection; secretase modulators; homeostasis regulators; mitochondrial enhancers; neuroinflammation; tau; small molecules; stem cells; RNAi

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Approaches in Molecular and Cellular Cancer Biology: Translating Basic Research to the Clinic

edited by

Rafael Coveñas Rodríguez

and

Maruan Hijazi Vega

submission deadline 29 Apr 2027 | Viewed by 81 | Submission Open

Keywords: cell signaling; proteomics; phosphoproteomics; mass spectrometry; kinase inhibitors; kinase activity; signaling networks; computational biology; peptide receptor antagonists; anticancer and cancer peptides

(This special issue belongs to the Section Molecular Oncology)

Male Infertility: Emerging Trends and Future Directions

edited by

Monica Muratori

and

Oumaima Ammar

submission deadline 29 Apr 2027 | Viewed by 76 | Submission Open

Keywords: male infertility; epigenetics; multi-omics; spermatogenesis; assisted reproduction; phytotherapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 30 Apr 2027 | 6 articles | Viewed by 11693 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Inflammasomes

edited by

Roberto Negro

submission deadline 30 Apr 2027 | 3 articles | Viewed by 4655 | Submission Open

Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis

(This special issue belongs to the Section Molecular Immunology)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Apr 2027 | 4 articles | Viewed by 4474 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3410 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application—2nd Edition

edited by

Erika Cione

and

Diana Abrego-Guandique

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3375 | Submission Open

Keywords: microRNA; non-coding RNA; gene regulation; biomarkers; RNA therapeutics; extracellular vesicles; microarray; NGS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Compounds in Cancer Treatment and Prevention: Mechanisms, Evidence, and Clinical Perspectives

edited by

Vitor Engracia Valenti

submission deadline 30 Apr 2027 | 2 articles | Viewed by 3245 | Submission Open

Keywords: natural compounds; cancer treatment; cancer prevention; bioactive phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research on Gut Microbiota in Health and Disease

edited by Li Cui

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3167 | Submission Open

Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut–brain axis; translational microbiome

(This special issue belongs to the Section Molecular Microbiology)

From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension

edited by

Swati Dabral

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3040 | Submission Open

Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation

(This special issue belongs to the Section Molecular Biology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2967 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights in Antimicrobial Resistance

edited by

Maria Teresa Mascellino

submission deadline 30 Apr 2027 | 1 articles | Viewed by 2964 | Submission Open

Keywords: drug resistance; microorganisms; molecular mechanisms; mobile genetic elements; CRISPR/Cas9; nucleic acid hybriditation; probes; LAMP

(This special issue belongs to the Section Molecular Microbiology)

Unraveling the Molecular Landscape of Systemic Lupus Erythematosus

edited by Yoshinori Matsumoto

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2964 | Submission Open

Keywords: systemic lupus erythematosus; autoimmunity; molecular mechanisms; immune regulation; type I interferon; biomarkers; multi-omics; signal transduction; precision medicine; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 30 Apr 2027 | 4 articles | Viewed by 2861 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

Protein–Protein Interactions in Human Cancer

edited by

Geng Wu

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2507 | Submission Open

Keywords: protein–protein interactions; protein–protein complexes; human cancer; signal transduction pathways; protein structure and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Lipids in Health and Diseases: 2nd Volume

edited by

Yutang Wang

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2339 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Emerging Therapeutic Strategies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2276 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

Kidney Disease: Molecular Insights and Emerging Therapies

edited by

Yaochun Zhang

submission deadline 30 Apr 2027 | 3 articles | Viewed by 2254 | Submission Open

Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

edited by

Michael C. Levin

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2209 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Mathematical Computation and Modeling in Biology

edited by

Shinuk Kim

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1939 | Submission Open

Keywords: mathematical model; computational methods; systemic molecular interaction; machine learning; integrating molecular materials

(This special issue belongs to the Section Molecular Informatics)

Probiotics, Prebiotics, Synbiotics, and Gut Microbial Modulation in Intestinal Health and Disease

edited by Koji Yamamoto

submission deadline 30 Apr 2027 | 3 articles | Viewed by 1765 | Submission Open

Keywords: gut microbiota; probiotics; prebiotics; synbiotics; inter-organ network; intestinal barrier; microbial metabolites; immunoregulation; multi-omics; inflammatory bowel disease; microbiome-based therapy

(This special issue belongs to the Section Molecular Microbiology)

Advances in Alzheimer’s Disease: From Metabolic Dysregulation to Molecular Pathophysiology and Therapeutics

edited by Pedro Cisternas

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1614 | Submission Open

Keywords: Alzheimer’s disease; metabolic dysregulation; brain insulin resistance; neuroenergetics; mitochondrial dysfunction; adipokines; neuroinflammation; gut–brain axis; multi-omics biomarkers; therapeutics and precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

State-of-the-Art Electrochemical Reaction Technologies

edited by

Cornelia Bandas

and

Carmen Lǎzǎu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1562 | Submission Open

Keywords: energy storage; electrochemical sensors; electrocatalysis; supercapacitors; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Lipid Metabolic and Signaling Dysregulations: From Molecular Mechanisms to Disease Pathogenesis

edited by Gergana M. Deevska

submission deadline 30 Apr 2027 | 3 articles | Viewed by 1354 | Submission Open

Keywords: lipid signaling; lipid metabolism; lipid homeostasis; metabolic dysregulation; signal transduction; disease pathogenesis

(This special issue belongs to the Section Molecular Biology)

Human Papillomavirus and Cellular Pathways

edited by

Marcus Vinícius de Aragão Batista

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1322 | Submission Open

Keywords: human papillomavirus; HPV oncogenesis; E6 and E7 oncoproteins; cellular signaling pathways; viral integration; epigenetics; molecular biomarkers; host susceptibility; cervical cancer; targeted therapy

(This special issue belongs to the Section Molecular Microbiology)

Advances in Alzheimer's Disease and Related Dementias: From Pathogenesis to Therapeutics

edited by

Amal Kaddoumi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1215 | Submission Open

Keywords: Alzheimer's disease; cerebral amyloid angiopathy; blood–brain barrier; cerebrovascular dysfunction; neuroinflammation; therapeutic development; translational research

(This special issue belongs to the Section Molecular Neurobiology)

New Research on Toxicology Research Models

edited by

Cláudia Maria Rosa Ribeiro

and

María Carolina Rocha-Pereira

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1050 | Submission Open

Keywords: contaminants of emerging concern; aquatic organisms; in vitro; in vivo; mammalian approaches; mechanisms of toxicity; environmental risk assessment; one health

(This special issue belongs to the Section Molecular Toxicology)

New Insights into Gastroesophageal Tumors

edited by

Michela Guardascione

and Luisa Foltran

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1035 | Submission Open

Keywords: gastric cancer; esophageal cancer; biomarkers; target therapy; immunotherapy; NGS

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets in Heart Failure

edited by Celestino Sardu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1025 | Submission Open

Keywords: heart failure; molecular mechanisms; ventricular remodeling; biomarkers; myocardial fibrosis; inflammation; oxidative stress; non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant Bioactive Compounds

edited by

Tarek Alshaal

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1025 | Submission Open

Keywords: plant bioactive compounds; phytochemicals; polyphenols; flavonoids; terpenoids; alkaloids; antioxidants; anti-inflammatory activity; molecular mechanisms; signaling pathways; gut microbiota; bioavailability; nutraceuticals; functional foods; phytochemistry; omics technologies; structure–activity relationship

(This special issue belongs to the Section Molecular Plant Sciences)

Multi-Omics Research in Oncology

edited by

Wenchao Gu

submission deadline 30 Apr 2027 | 1 articles | Viewed by 952 | Submission Open

Keywords: multi-omics; cancer genomics; transcriptomics; single-cell sequencing; spatial omics; machine learning; artificial intelligence; biomarker discovery

(This special issue belongs to the Section Molecular Oncology)

Phytohormones in Plant Responses to Abiotic Stress

edited by

Marzena Kurowska

submission deadline 30 Apr 2027 | 1 articles | Viewed by 935 | Submission Open

Keywords: phytohormones; hormone signaling; abiotic stress responses; signaling crosstalk; transcriptional regulation; gene expression; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Products and Synthetic Molecules: Development of Novel Anticancer Drugs

edited by Vinícius D’Ávila Bitencourt Pascoal

submission deadline 30 Apr 2027 | Viewed by 778 | Submission Open

Keywords: anticancer drugs; natural products; synthetic molecules; bioactive compounds; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antibacterial Drug Discovery and Molecular Mechanisms of Antimicrobial Resistance

edited by

Eduardo Martins De Sousa

submission deadline 30 Apr 2027 | 1 articles | Viewed by 719 | Submission Open

Keywords: antibacterial drug discovery; molecular mechanisms of resistance; molecular microbiology; antibiotic targets; structure–function relationships; bacterial efflux pumps; drug-inactivating enzymes; bacterial biofilms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Nutrition and Food Science

edited by

Sze Ying Leong

and

Indrawati Oey

submission deadline 30 Apr 2027 | 1 articles | Viewed by 711 | Submission Open

Keywords: molecular nutrition; functional foods; bioactives; food matrix; nutrient bioavailability; digestion kinetics; gut microbiota; nutritional functionality; food structure–function relationships; food reformulation; food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stem Cell and Epigenetic Regulation in Regenerative Medicine

edited by

Giuseppe Garroni

submission deadline 30 Apr 2027 | Viewed by 610 | Submission Open

Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell–environment interactions; conditioned medium; secreted factors; epigenetic modification

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2951-3000 on page 60 of 62.

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