Molecular Mechanisms, Biomarkers, and Therapeutic Targets in Heart Failure
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 9
Special Issue Editor
Interests: heart failure; ventricular remodeling; myocardial dysfunction; heart failure with preserved ejection fraction (HFpEF); heart failure with reduced ejection fraction (HFrEF); biomarkers in heart failure; multimodality cardiac imaging
Special Issue Information
Dear Colleagues,
Heart failure (HF) is a multifaceted clinical syndrome resulting from the interplay of molecular, cellular, metabolic, and systemic derangements that progressively impair cardiac structure and function. Despite substantial advances in pharmacological and device-based therapies, HF continues to be associated with high morbidity and mortality, highlighting the need for a deeper understanding of its underlying biological mechanisms and for the identification of novel biomarkers and therapeutic targets.
This Special Issue aims to provide a comprehensive and updated overview of the molecular mechanisms driving the onset and progression of heart failure, with particular attention to both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). Contributions addressing ventricular remodeling, myocardial fibrosis, inflammation, oxidative stress, metabolic and mitochondrial dysfunction, calcium handling abnormalities, and cardiomyocyte–non-cardiomyocyte interactions are especially encouraged.
The Special Issue welcomes original research articles, systematic reviews, and focused narrative reviews covering basic, translational, and clinical research. Topics of interest include, but are not limited to, the following:
- Molecular and cellular pathways involved in adverse and reverse ventricular remodeling;
- Gene and protein expression profiling in experimental and human heart failure;
- Epigenetic mechanisms and the role of non-coding RNAs (miRNAs, lncRNAs, circRNAs) in HF pathophysiology;
- Novel circulating and tissue biomarkers for diagnosis, prognosis, and therapeutic monitoring;
- Inflammatory and immune mechanisms contributing to myocardial dysfunction;
- Oxidative stress, redox signaling, and mitochondrial alterations in failing myocardium;
- Metabolic reprogramming and energy metabolism in heart failure;
- Identification and validation of emerging molecular therapeutic targets;
- Translational approaches bridging preclinical discoveries with clinical applications.
By integrating mechanistic insights with translational and clinical perspectives, this Special Issue seeks to advance precision medicine strategies in heart failure, fostering the development of innovative diagnostic tools and targeted therapies.
Prof. Dr. Celestino Sardu
Guest Editor
Manuscript Submission Information
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Keywords
- heart failure
- molecular mechanisms
- ventricular remodeling
- biomarkers
- myocardial fibrosis
- inflammation
- oxidative stress
- non-coding RNAs
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