Stem Cell and Epigenetic Regulation in Regenerative Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 40
Special Issue Editor
Interests: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; conditioned medium; secreted factors; epigenetic modification; bioactive molecules; cell senescence; repairing mechanisms; skin aging
Special Issue Information
Dear Colleagues,
Regenerative medicine aims to restore the structure and function of damaged tissues and organs by harnessing the potential of stem cells. These cells, characterized by their ability to self-renew and differentiate into specialized cell types, are central to tissue engineering and cell-based therapies. However, their fate is not determined solely by intrinsic properties: the surrounding cellular environment—or stem cell niche—plays a pivotal role. This microenvironment includes neighboring cells, extracellular matrix components, soluble factors, and mechanical cues, all of which interact in a complex manner to regulate stem cell behavior at the molecular level. Epigenetic mechanisms also significantly influence stem cell fate, with modifications in DNA methylation, histone modifications, and non-coding RNA expression regulating gene activity in response to environmental cues.
Gaining deeper insight into these molecular interactions, including epigenetic regulation, is crucial for optimizing regenerative strategies.
This Special Issue invites contributions exploring how the stem cell niche and epigenetic factors influence stem cell behavior, including differentiation, proliferation, and migration, with a focus on experimental and translational studies.
Dr. Giuseppe Garroni
Guest Editor
Manuscript Submission Information
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Keywords
- mesenchymal stem cells
- regenerative medicine
- stemness genes
- stem cell differentiation
- molecular regulation
- gene expression
- cell–environment interactions
- conditioned medium
- secreted factors
- epigenetic modification
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