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Multi-Omics Research in Oncology

A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 April 2027 | Viewed by 952

Editor

Department of Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
Interests: radiomics; bioinformatics; cancers; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this Special Issue entitled “Multi-Omics Research in Oncology”, which aims to highlight recent advances in integrative cancer research through the combination of high-throughput sequencing technologies and data-driven analytical approaches.

This Special Issue welcomes studies utilizing genomics, transcriptomics, epigenomics, proteomics, single-cell and spatial omics, as well as emerging pathomics and radiomics approaches that extract quantitative information from digital pathology and medical imaging. Together, these complementary data modalities provide a more comprehensive understanding of tumor biology, heterogeneity, and the tumor microenvironment.

We particularly encourage contributions that apply machine learning, deep learning, and artificial intelligence to integrate multi-modal datasets, identify robust biomarkers, and improve cancer diagnosis, prognosis, and therapeutic response prediction. Both methodological developments and translational or clinical studies are welcome.

By integrating molecular sequencing data with imaging- and pathology-derived features, this Special Issue aims to promote interdisciplinary research and accelerate the translation of multi-omics discoveries into precision oncology.

Dr. Wenchao Gu
Guest Editor

Manuscript Submission Information

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Keywords

  • multi-omics
  • cancer genomics
  • transcriptomics
  • single-cell sequencing
  • spatial omics
  • machine learning
  • artificial intelligence
  • biomarker discovery

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Published Papers (1 paper)

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Research

23 pages, 5143 KB  
Article
Emphysema Shapes a Pro-Inflammatory Immune Microenvironment in Pulmonary Adenocarcinoma: A Pilot Immune Transcriptomic Profiling Study
by Jeong Uk Lim, Seohyeon Kim, Tai Joon An, Young Jo Sa, Hyo Rim Kim, Chan Kwon Park, Hyoung Kyu Yoon and Tae-Jung Kim
Int. J. Mol. Sci. 2026, 27(9), 3958; https://doi.org/10.3390/ijms27093958 - 29 Apr 2026
Viewed by 635
Abstract
Emphysema is a well-recognized risk factor for lung cancer; however, its influence on the immunologic tumor microenvironment in lung adenocarcinoma remains poorly defined. In this pilot, hypothesis-generating study, immune-related gene expression profiling was performed using archival formalin-fixed paraffin-embedded tumor specimens from 12 patients [...] Read more.
Emphysema is a well-recognized risk factor for lung cancer; however, its influence on the immunologic tumor microenvironment in lung adenocarcinoma remains poorly defined. In this pilot, hypothesis-generating study, immune-related gene expression profiling was performed using archival formalin-fixed paraffin-embedded tumor specimens from 12 patients with lung adenocarcinoma, including the Never-smoker group (never-smokers without emphysema; n = 4), the Smoker 1 group (smokers without emphysema; n = 3), and the Smoker 2 group (smokers with CT-defined emphysema; n = 5). Expression of 770 immune-related genes was analyzed using the nCounter PanCancer IO 360 Panel (NanoString Technologies, Seattle, WA, USA). Compared with the Never-smoker group, tumors from the Smoker 1 group showed marked upregulation of SFRP1, SERPINB5, and IL6, whereas tumors from the Smoker 2 group exhibited increased expression of KIR2DL3, BLK, and WNT2B. Relative to the Smoker 1 group, the Smoker 2 group demonstrated significant upregulation of MMP7, TDO2, and CCL18. Pathway enrichment analysis revealed cytokine–cytokine receptor interaction as the most prominently enriched pathway in both smoker groups, while the IL-17 signaling pathway was preferentially enriched in the Smoker 2 group. In addition, diffusing capacity for carbon monoxide showed significant correlations with immune-related genes including IL-6 and IL-6R. Collectively, these preliminary findings suggest that lung adenocarcinoma arising in emphysematous lungs may be characterized by a distinct pro-inflammatory immune microenvironment. Given the small sample size and potential confounders, these results should be regarded as hypothesis-generating. Emphysema-associated immune remodeling may nevertheless represent an important biological factor worthy of validation in larger, independent cohorts. Full article
(This article belongs to the Special Issue Multi-Omics Research in Oncology)
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