Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies

Dear Colleagues,

Abnormal cell proliferation is a common core feature of many diseases, particularly tumors and autoimmune disorders. Immune microenvironment imbalance is a key factor regulating abnormal cell proliferation. The imbalanced immune microenvironment and abnormally proliferating cells often trigger and sustain disease progression. In tumors, chronic inflammation serves as a critical driver for the initiation and development of malignant neoplasms. In psoriasis, pro-inflammatory factors such as IL-17, IL-1β, and IL-6 induce abnormal proliferation of keratinocytes, leading to the formation of white scales; the abnormally proliferating keratinocytes in turn secrete pro-inflammatory factors, recruiting immune cells and activating inflammatory responses. In rheumatoid arthritis, synovial cells in the joints undergo abnormal proliferation in response to external inflammatory stimuli, resulting in synovial hyperplasia and joint swelling. Therefore, deciphering the interaction mechanisms between the imbalanced immune microenvironment and abnormally proliferating cells is of great significance for understanding the occurrence and development of diseases such as tumors and autoimmune disorders. Meanwhile, modulating the imbalanced immune microenvironment can, to some extent, eliminate cytokines that trigger abnormal cell proliferation and alleviate disease symptoms, representing a novel therapeutic strategy for many diseases.

This Special Issue primarily focuses on elucidating the molecular mechanisms by which the immune microenvironment regulates abnormal or malignant cell proliferation from both experimental and clinical research perspectives, aiming to develop new treatment strategies.

Dr. Xingkang Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.