Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 25 July 2026 | Viewed by 2
Special Issue Editors
Interests: biomarkers; therapeutic targets and compounds for Parkinson's disease and other neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; neurobiology; neuroscience; apoptosis; neurodegenerative diseases; neurophysiology; gene expression; genetics; cell biology; cell proliferation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are a group of heterogeneous disorders characterized with progressive neuron vulnerability and even neuron demise in the brain or peripheral nervous system, which are listed within the leading causes of human death. Among various neurodegenerative conditions, Alzheimer's disease and Parkinson's disease (PD) are the most common neurodegenerative disorders. With the aging of our population, the prevalence of neurodegenerative diseases increases significantly, posing serious challenges to health and economies all across the world. Although oxidative stress, protein aggregation, mitochondria impairment, and neuroinflammation are relevant to neurodegeneration, the disease pathogenesis is not fully understood, and no therapy is available for these degenerative disorders. Recently, cell therapies using human cell-derived dopamine neurons to replace lost neurons in the brains of PD patients showed promise, and the first human clinical trial of the transplantation of induced pluripotent stem cell-derived human dopamine progenitors is under investigation at the Center for iPS Cell Research and Application (CiRA), Kyoto University, which brings hope to patients with PD and other degenerative diseases.
The aim of this Special Issue is to discuss disease pathogenesis and new therapeutic agents or strategies to protect or alleviate neurodegeneration in human neurodegenerative disorders
Dr. Zhidong Zhou
Dr. Alexandre Hiroaki Kihara
Guest Editors
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Keywords
- neurodegeneration
- neurodegenerative diseases
- protein aggregation
- pathogenesis
- therapy
- mitochondria
- neuroinflammation
- oxidative stress
- cell therapy
- clinical trial
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